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Volumn 19, Issue 2, 2011, Pages 883-893

Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists

(14) Haga, Yuji a Mizutani, Sayaka a Naya, Akira a Kishino, Hiroyuki a Iwaasa, Hisashi a Ito, Masahiko a Ito, Junko a Moriya, Minoru a Sato, Nagaaki a Takenaga, Norihiro a Ishihara, Akane a Tokita, Shigeru a Kanatani, Akio a Ohtake, Norikazu a

a BANYU PHARMACEUTICAL CO LTD (Japan)

Author keywords

Anti obesity; MCH1R antagonist; Melanin concentrating hormone; N Phenylpyridone

Indexed keywords

1 (4 {2 [BENZYL(METHYL)AMINO]ETHOXY}PHENYL) 4 (BENZYLOXY)PYRIDIN 2(1) ONE; 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL} 4 {[4 (TRIFLUOROMETHYL)BENZYL]OXY}PYRIDIN 2(1) ONE; 4 (4 FLUOROPHENOXY) 1 {4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL}PYRIDIN 2(1) ONE; 4 (4 FLUOROPHENYL) 1 {4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL}PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 (4 {[1 (DIMETHYLAMINO) 2 METHYL PROPAN 2 YL]OXY}PHENYL)PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 (4 {[1 (DIMETHYLAMINO)PROPAN 2 YL] OXY}PHENYL)PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 (4 {[2 (DIETHYLAMINO)ETHYL]AMINO} PHENYL)PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [(1 METHYLPIPERIDIN 2 YL)METHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [(1 METHYLPYRROLIDIN 2 YL)METHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [(1 METHYLPYRROLIDIN 3 YL)OXY] PHENYL}PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [2 (DIETHYLAMINO)ETHOXY]PHENYL} PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [2 (DIISOPROPYLAMINO)ETHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [2 (DIMETHYLAMINO)ETHOXY]PHENYL} PYRIDIN 2(1)-ONE; 4 (BENZYLOXY) 1 {4 [2 (MORPHOLIN 4 YL)ETHOXY]PHENYL} PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL} PYRIDIN 2(1) ONE; 4 (BENZYLOXY) 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL} PYRIDIN 2(1) ONE; 4 (BIPHENYL 4 YLMETHOXY) 1 {4 [2 (PYRROLIDIN 1 YL) ETHOXY]PHENYL}PYRIDIN 2(1) ONE; 4 (NAPHTHALEN 2 YLMETHOXY) 1 {4 [2 (PYRROLIDIN 1 YL) ETHOXY]PHENYL}PYRIDIN 2(1) ONE; 4 [(2 CHLOROBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 [(2 FLUOROBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 [(3 CHLOROBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 [(3 FLUOROBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 [(4 CHLOROBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY] PHENYL}PYRIDIN 2(1) ONE; 4 [(4 FLUOROBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL}PYRIDIN 2(1) ONE; 4 [(4 METHOXYBENZYL)OXY] 1 {4 [2 (PYRROLIDIN 1 YL) ETHOXY]PHENYL}PYRIDIN 2(1) ONE; 4 [2 (4 FLUOROPHENOXY)ETHOXY] 1 {4 [2 (PYRROLIDIN 1 YL) THOXY]PHENYL}PYRIDIN 2(1) ONE; 4 [2 (4 FLUOROPHENYL)ETHOXY] 1 {4 [2 (PYRROLIDIN 1 YL) ETHOXY]PHENYL}PYRIDIN 2(1) ONE; DIPYRONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG SYNTHESIS; MOUSE; NONHUMAN; OBESITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICE, OBESE; PYRIDONES; RATS; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 78651489797 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.12.002 Document Type: Article

Times cited : (10)

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