Quantitative assessment of the influence of hematopoietically expressed homeobox variant (rs1111875) on type 2 diabetes risk

Molecular Genetics and Metabolism

Volumn 102, Issue 2, 2011, Pages 194-199

  Wang, Yudong ^a   Qiao, Weiwei ^b   Zhao, Xianzhe ^b   Tao, Minfang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

HHEX; Meta analysis; Single nucleotide polymorphism; Susceptibility; Type 2 diabetes

Indexed keywords

GLUCOSE;

AFRICAN AMERICAN; ALLELE; ARTICLE; ASIAN; CAUCASIAN; DISEASE ASSOCIATION; ETHNICITY; GENETIC HETEROGENEITY; GENETIC MODEL; GENETIC SUSCEPTIBILITY; HEMATOPOIETICALLY EXPRESSED HOMEOBOX GENE; HOMEOBOX; HUMAN; INDIAN; MAJOR CLINICAL STUDY; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HEMATOPOIESIS; HOMEODOMAIN PROTEINS; HUMANS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; TRANSCRIPTION FACTORS;

EID: 78651463419     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2010.09.013     Document Type: Article

References (42)

1. Boutayeb A., Boutayeb S. The burden of non communicable diseases in developing countries. Int. J. Equity. Health. 2005, 4:2.
2. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.
3. Frayling T.M. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat. Rev. Genet. 2007, 8:657-662.
4. Zeggini E. A new era for type 2 diabetes genetics. Diabet. Med. 2007, 24:1181-1186.
5. Bort R., Martinez-Barbera J.P., Beddington R.S., Zaret K.S. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004, 131:797-806.
6. Farris W., Mansourian S., Chang Y., et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. USA 2003, 100:4162-4167.
7. Smith U. TCF7L2 and type 2 diabetes - we WNT to know. Diabetologia 2007, 50:5-7.
8. Foley A.C., Mercola M. Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes. Dev. 2005, 19:387-396.
9. Stroup D.F., Berlin J.A., Morton S.C., et al. Meta-analysis of observational studies in epidemiology, a proposal for reporting. JAMA. 2000, 283:2008-2012. MOOSE group.
10. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control. Clin. Trials. 1986, 7:177-188.
11. Egger M., et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997, 315:629-634.
12. Sladek R., Rocheleau G., Rung J., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445:881-885.
13. Zeggini E., Weedon M.N., Lindgren C.M., Frayling T.M., Elliott K.S., Lango H., Timpson N.J., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007, 316:1336-1341.
14. Scott L.J., Mohlke K.L., Bonnycastle L.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007, 316:1341-1345.
15. Grarup N., Rose C.S., Andersson E.A., et al. Studies of association of variants near the HHEX, CDKN2A/B and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10, 705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 2007, 56:3105-3111.
16. Schulze M.B., Al-Hasani H., Boeing H., Fisher E., Döring F., Joost H.G. Variation in the HHEX-IDE gene region predisposes to type 2 diabetes in the prospective, population-based EPIC-Potsdam cohort. Diabetologia 2007, 50:2405-2407.
17. Horikoshi M., Hara K., Ito C., Shojima N., Nagai R., Ueki K., Froguel P., Kadowaki T. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 2007, 50:2461-2466.
18. Lee Y.H., Kang E.S., Kim S.H., Han S.J., Kim C.H., Kim H.J., Ahn C.W., Cha B.S., Nam M., Nam C.M., Lee H.C. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet. 2008, 53:991-998.
19. Wu Y., Li H., Loos R.J., Yu Z., Ye X., Chen L., Pan A., Hu F.B., Lin X. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 2008, 57:2834-2842.
20. Sanghera D.K., Ortega L., Han S., Singh J., Ralhan S.K., Wander G.S., Mehra N.K., et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC. Med. Genet. 2008, 9:59.
21. Horikawa Y., Miyake K., Yasuda K., Enya M., Hirota Y., et al. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J. Clin. Endocrinol. Metab. 2008, 93:3136-3141.
22. Ng M.C., Park K.S., Oh B., Tam C.H., Cho Y.M., et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6, 719 Asians. Diabetes 2008, 57:2226-2233.
23. Lewis J.P., Palmer N.D., Hicks P.J., Sale M.M., Langefeld C.D., Freedman B.I., Divers J., Bowden D.W. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 2008, 57:2220-2225.
24. Hertel J.K., Johansson S., Raeder H., Midthjell K., Lyssenko V., Groop L., Molven A., Njølstad P.R. Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). Diabetologia 2008, 51:971-977.
25. Takeuchi F., Serizawa M., Yamamoto K., Fujisawa T., et al. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 2009, 58:1690-1699.
26. van Vliet-Ostaptchouk J.V., Onland-Moret N.C., van Haeften T.W., et al. HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. Eur. J. Hum. Genet. 2008, 16:652-656.
27. Furukawa Y., Shimada T., Furuta H., et al. Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J. Clin. Endocrinol. Metab. 2008, 93:310-314.
28. Lyssenko V., Jonsson A., Almgren P., Pulizzi N., et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N. Engl. J. Med. 2008, 359:2220-2232.
29. Rong R., Hanson R.L., Ortiz D., Wiedrich C., Kobes S., Knowler W.C., Bogardus C., Baier L.J. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 2009, 58:478-488.
30. Omori S., Tanaka Y., Takahashi A., et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008, 57:791-795.
31. Pivovarova O., Nikiforova V.J., Pfeiffer A.F., Rudovich N. The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort. Diabetes. Metab. Res. Rev. 2009, 25:156-162.
32. Tabara Y., Osawa H., Kawamoto R., Onuma H., Shimizu I., Miki T., Kohara K., Makino H. Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 2009, 58:493-498.
33. Hu C., Zhang R., Wang C., et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS. One 2009, 4:e7643.
34. Chauhan G., Spurgeon C.J., et al. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2 and CDKAL1 on the risk of type 2 diabetes in 5164 Indians. Diabetes 2010, 59:2068-2074.
35. Tan J.T., Ng D.P., Nurbaya S., Seielstad M., Tai E.S., et al. Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J. Clin. Endocrinol. Metab. 2010, 95:390-397.
36. Lin Y., Li P., Cai L., et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC. Medical Genetics 2010, 11:97.
37. Gupta V., Khadgawat R., Ng H.K., Kumar S., Aggarwal A., Rao V.R., Sachdeva M.P. A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India. Ann. Hum. Genet. 2010, 74:361-368.
38. McLin V.A., Rankin S.A., Zorn A.M. Repression of Wnt/beta catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 2007, 134:2207-2217.
39. Kirchhoff K., Machicao F., Haupt A., Schafer S.A., Tschritter O., Staiger H., Stefan N., Haring H.U., Fritsche A. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 2008, 51:597-601.
40. Pascoe L., Tura A., Patel S.K., Ibrahim I.M., et al. Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007, 56:3101-3104.
41. Staiger H., Machicao F., Stefan N., Tschritter O., Thamer C., Kantartzis K., Schafer S.A., Kirchhoff K., Fritsche A., Haring H.U. Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS. ONE 2007, 2:e832.
42. Staiger H., Stancakova A., Zilinskaite J., et al. A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 2008, 57:514-517.