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Volumn 49, Issue 1, 2011, Pages 38-45

Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1

Author keywords

(PPAR ,); 1 (TGF ,1); Baicalin; Carbon tetrachloride (CCl4); Hepatic fibrosis; Peroxisome proliferator activated receptors ; Transforming growth factor

Indexed keywords

BAICALIN; CARBON TETRACHLORIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SILYMARIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 78651337662     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2010.493179     Document Type: Article
Times cited : (43)

References (39)
  • 1
    • 0036554139 scopus 로고    scopus 로고
    • Regulation of murine macrophage proinfamma-tory and anti-infammatory cytokines by ligands for peroxisome proliferator-activated receptor-gamma: Counter-regulatory activity by IFN-gamma
    • Alleva DG, Johnson EB, Lio FM, Boehme SA, Conlon PJ, Crowe PD. (2002). Regulation of murine macrophage proinfamma-tory and anti-infammatory cytokines by ligands for peroxisome proliferator-activated receptor-gamma: Counter-regulatory activity by IFN-gamma. J Leukoc Biol, 71, 677-685.
    • (2002) J Leukoc Biol , vol.71 , pp. 677-685
    • Alleva, D.G.1    Johnson, E.B.2    Lio, F.M.3    Boehme, S.A.4    Conlon, P.J.5    Crowe, P.D.6
  • 5
    • 52949122935 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: Peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-beta1
    • Chang HJ, Lee JH, Hwang KJ, Kim MR, Chang KH, Park DW, Min CK. (2008). Transforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: Peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-beta1. Fertil Steril, 90, 1357-1365.
    • (2008) Fertil Steril , vol.90 , pp. 1357-1365
    • Chang, H.J.1    Lee, J.H.2    Hwang, K.J.3    Kim, M.R.4    Chang, K.H.5    Park, D.W.6    Min, C.K.7
  • 6
    • 0034693323 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B
    • Chung SW, Kang BY, Kim SH, Pak YK, Cho D, Trinchieri G, Kim TS. (2000). Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. J Biol Chem, 275, 32681-32687.
    • (2000) J Biol Chem , vol.275 , pp. 32681-32687
    • Chung, S.W.1    Kang, B.Y.2    Kim, S.H.3    Pak, Y.K.4    Cho, D.5    Trinchieri, G.6    Kim, T.S.7
  • 7
    • 0023913120 scopus 로고
    • Te steroid and thyroid hormone receptor super-family
    • Evans RM. (1988). Te steroid and thyroid hormone receptor super-family. Science, 240, 889-895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 8
    • 0032794576 scopus 로고    scopus 로고
    • Cytokines and fbrogenesis
    • Friedman SL. (1999). Cytokines and fbrogenesis. Semin Liver Dis, 19, 129-140.
    • (1999) Semin Liver Dis , vol.19 , pp. 129-140
    • Friedman, S.L.1
  • 9
    • 0028289518 scopus 로고
    • Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo
    • Friedman SL, Yamasaki G, Wong L. (1994). Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. J Biol Chem, 269, 10551-10558.
    • (1994) J Biol Chem , vol.269 , pp. 10551-10558
    • Friedman, S.L.1    Yamasaki, G.2    Wong, L.3
  • 10
    • 38549153486 scopus 로고    scopus 로고
    • 4-caused injury and fbrogenesis by attenuating oxidative stress and suppressing infammation
    • Fu Y, Zheng S, Lin J, Ryerse J, Chen A. (2008). Curcumin protects the rat liver from CCl4-caused injury and fbrogenesis by attenuating oxidative stress and suppressing infammation. Mol Pharmacol, 73, 399-409.
    • (2008) Mol Pharmacol , vol.73 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3    Ryerse, J.4    Chen, A.5
  • 11
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma tran-scriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
    • Galli A, Crabb D, Price D, Ceni E, Salzano R, Surrenti C, Casini A. (2000). Peroxisome proliferator-activated receptor gamma tran-scriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. Hepatol-ogy, 31, 101-108.
    • (2000) Hepatol-ogy , vol.31 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3    Ceni, E.4    Salzano, R.5    Surrenti, C.6    Casini, A.7
  • 12
    • 0031752720 scopus 로고    scopus 로고
    • Levels of transforming growth factor beta and transforming growth factor beta receptors in rat liver during growth, regression by apoptosis and neoplasia
    • Grasl-Kraupp B, Rossmanith W, Ruttkay-Nedecky B, Müllauer L, Kammerer B, Bursch W, Schulte-Hermann R. (1998). Levels of transforming growth factor beta and transforming growth factor beta receptors in rat liver during growth, regression by apoptosis and neoplasia. Hepatology, 28, 717-726.
    • (1998) Hepatology , vol.28 , pp. 717-726
    • Grasl-Kraupp, B.1    Rossmanith, W.2    Ruttkay-Nedecky, B.3    Müllauer, L.4    Kammerer, B.5    Bursch, W.6    Schulte-Hermann, R.7
  • 13
    • 33744538682 scopus 로고    scopus 로고
    • Modern pathogenetic concepts of liver fbrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    • Gressner AM, Weiskirchen R. (2006). Modern pathogenetic concepts of liver fbrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med, 10, 76-99.
    • (2006) J Cell Mol Med , vol.10 , pp. 76-99
    • Gressner, A.M.1    Weiskirchen, R.2
  • 14
    • 53249092406 scopus 로고    scopus 로고
    • Pharmacological application of cafeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-depen-dent pathways
    • Gressner OA, Lahme B, Rehbein K, Siluschek M, Weiskirchen R, Gressner AM. (2008). Pharmacological application of cafeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-depen-dent pathways. J Hepatol, 49, 758-767.
    • (2008) J Hepatol , vol.49 , pp. 758-767
    • Gressner, O.A.1    Lahme, B.2    Rehbein, K.3    Siluschek, M.4    Weiskirchen, R.5    Gressner, A.M.6
  • 15
    • 0032911531 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2E1 expression by oleanolic acid: Hepatoprotective effects against carbon tetrachlo-ride-induced hepatic injury
    • Jeong HG. (1999). Inhibition of cytochrome P450 2E1 expression by oleanolic acid: Hepatoprotective effects against carbon tetrachlo-ride-induced hepatic injury. Toxicol Lett, 105, 215-222.
    • (1999) Toxicol Lett , vol.105 , pp. 215-222
    • Jeong, H.G.1
  • 16
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte infammatory cytokines
    • Jiang C, Ting AT, Seed B. (1998). PPAR-gamma agonists inhibit production of monocyte infammatory cytokines. Nature, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 17
    • 58149127646 scopus 로고    scopus 로고
    • PPAR-gamma agonist attenuates renal interstitial fbrosis and infammation through reduction of TGF-beta
    • Kawai T, Masaki T, Doi S, Arakawa T, Yokoyama Y, Doi T, Kohno N, Yorioka N. (2009). PPAR-gamma agonist attenuates renal interstitial fbrosis and infammation through reduction of TGF-beta. Lab Invest, 89, 47-58.
    • (2009) Lab Invest , vol.89 , pp. 47-58
    • Kawai, T.1    Masaki, T.2    Doi, S.3    Arakawa, T.4    Yokoyama, Y.5    Doi, T.6    Kohno, N.7    Yorioka, N.8
  • 18
    • 33745279115 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: Role for Zf9 dephosphorylation
    • Lee SJ, Yang EK, Kim SG. (2006). Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: Role for Zf9 dephosphorylation. Mol Pharmacol, 70, 415-425.
    • (2006) Mol Pharmacol , vol.70 , pp. 415-425
    • Lee, S.J.1    Yang, E.K.2    Kim, S.G.3
  • 19
    • 0032801286 scopus 로고    scopus 로고
    • Liver fbrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
    • Li D, Friedman SL. (1999). Liver fbrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy. J Gastroen-terol Hepatol, 14, 618-633.
    • (1999) J Gastroen-terol Hepatol , vol.14 , pp. 618-633
    • Li, D.1    Friedman, S.L.2
  • 20
    • 34047203049 scopus 로고    scopus 로고
    • Baicalin protects mouse from concanavalin A-in-duced liver injury through inhibition of cytokine production and hepatocyte apoptosis
    • Liu LL, Gong LK, Wang H, Xiao Y, Wu XF, Zhang YH, Xue X, Qi XM, Ren J. (2007). Baicalin protects mouse from concanavalin A-in-duced liver injury through inhibition of cytokine production and hepatocyte apoptosis. Liver Int, 27, 582-591.
    • (2007) Liver Int , vol.27 , pp. 582-591
    • Liu, L.L.1    Gong, L.K.2    Wang, H.3    Xiao, Y.4    Wu, X.F.5    Zhang, Y.H.6    Xue, X.7    Qi, X.M.8    Ren, J.9
  • 21
    • 32244440927 scopus 로고    scopus 로고
    • SMAD3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cells
    • Liu X, Wang W, Hu H, Tang N, Zhang C, Liang W, Wang M. (2006). SMAD3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cells. Pharm Res, 23, 82-89.
    • (2006) Pharm Res , vol.23 , pp. 82-89
    • Liu, X.1    Wang, W.2    Hu, H.3    Tang, N.4    Zhang, C.5    Liang, W.6    Wang, M.7
  • 22
    • 40749086831 scopus 로고    scopus 로고
    • Transforming growth factor-beta and hepatocyte transdiferentiation in liver fbrogenesis
    • Meindl-Beinker NM, Dooley S. (2008). Transforming growth factor-beta and hepatocyte transdiferentiation in liver fbrogenesis. J Gastroenterol Hepatol, 23, S122-127.
    • (2008) J Gastroenterol Hepatol , vol.23
    • Meindl-Beinker, N.M.1    Dooley, S.2
  • 24
    • 23744479064 scopus 로고    scopus 로고
    • Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats
    • Orfla C, Lepert JC, Alric L, Carrera G, Béraud M, Pipy B. (2005). Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats. Histochem Cell Biol, 123, 585-593.
    • (2005) Histochem Cell Biol , vol.123 , pp. 585-593
    • Orfla, C.1    Lepert, J.C.2    Alric, L.3    Carrera, G.4    Béraud, M.5    Pipy, B.6
  • 26
    • 38549093443 scopus 로고    scopus 로고
    • Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice
    • Park SW, Lee CH, Kim YS, Kang SS, Jeon SJ, Son KH, Lee SM. (2008). Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice. J Pharmacol Sci, 106, 136-143.
    • (2008) J Pharmacol Sci , vol.106 , pp. 136-143
    • Park, S.W.1    Lee, C.H.2    Kim, Y.S.3    Kang, S.S.4    Jeon, S.J.5    Son, K.H.6    Lee, S.M.7
  • 28
    • 0038468558 scopus 로고    scopus 로고
    • SMAD3: A key player in pathogenetic mechanisms dependent on TGF-beta
    • Roberts AB, Russo A, Felici A, Flanders KC. (2003). SMAD3: A key player in pathogenetic mechanisms dependent on TGF-beta. Ann N Y Acad Sci, 995, 1-10.
    • (2003) Ann N y Acad Sci , vol.995 , pp. 1-10
    • Roberts, A.B.1    Russo, A.2    Felici, A.3    Flanders, K.C.4
  • 29
    • 0029923670 scopus 로고    scopus 로고
    • Te prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fbrosis induced by choline-defcient l-amino acid-defned diet
    • Sakaida I, Matsumura Y, Kubota M, Kayano K, Takenaka K, Okita K. (1996). Te prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fbrosis induced by choline-defcient l-amino acid-defned diet. Hepatology, 23, 755-763.
    • (1996) Hepatology , vol.23 , pp. 755-763
    • Sakaida, I.1    Matsumura, Y.2    Kubota, M.3    Kayano, K.4    Takenaka, K.5    Okita, K.6
  • 35
    • 44149100002 scopus 로고    scopus 로고
    • Protective effect of baicalin against lipopolysaccharide/d-galactosamine- induced liver injury in mice by up-regulation of heme oxygenase-1
    • Wan JY, Gong X, Zhang L, Li HZ, Zhou YF, Zhou QX. (2008). Protective effect of baicalin against lipopolysaccharide/d-galactosamine-induced liver injury in mice by up-regulation of heme oxygenase-1. Eur J Pharmacol, 587, 302-308.
    • (2008) Eur J Pharmacol , vol.587 , pp. 302-308
    • Wan, J.Y.1    Gong, X.2    Zhang, L.3    Li, H.Z.4    Zhou, Y.F.5    Zhou, Q.X.6
  • 36
    • 0346099209 scopus 로고    scopus 로고
    • Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride
    • Yokogawa K, Watanabe M, Takeshita H, Nomura M, Mano Y, Miyamoto K. (2004). Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride. Int J Pharm, 269, 479-489.
    • (2004) Int J Pharm , vol.269 , pp. 479-489
    • Yokogawa, K.1    Watanabe, M.2    Takeshita, H.3    Nomura, M.4    Mano, Y.5    Miyamoto, K.6
  • 38
    • 14044278644 scopus 로고    scopus 로고
    • Efects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury
    • Zhao Y, Li H, Gao Z, Xu H. (2005). Efects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury. Eur J Pharmacol, 509, 195-200.
    • (2005) Eur J Pharmacol , vol.509 , pp. 195-200
    • Zhao, Y.1    Li, H.2    Gao, Z.3    Xu, H.4
  • 39
    • 33645803853 scopus 로고    scopus 로고
    • Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor
    • Zheng S, Chen A. (2006). Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am J Physiol Gastrointest Liver Physiol, 290, G883-893.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Zheng, S.1    Chen, A.2


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