Peroxisome proliferator-activated receptor-γ and retinoic acid X receptor α represses the TGFβ1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: Role for Zf9 dephosphorylation

Molecular Pharmacology

Volumn 70, Issue 1, 2006, Pages 415-425

  Seung, Jin Lee ^a   Eun, Kyoung Yang ^a   Sang, Geon Kim ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ALITRETINOIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN ZF9; RETINOID X RECEPTOR; S6 KINASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CHROMOSOME 10; CONTROLLED STUDY; DRUG ACTIVATION; DRUG INHIBITION; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GENE EXPRESSION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION; IMMUNOBLOTTING; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PPAR GAMMA; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN D2; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECOMBINANT FUSION PROTEINS; RETINOID X RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TRANSFECTION; TRANSFORMING GROWTH FACTOR ALPHA; TRETINOIN;

EID: 33745279115     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.022954     Document Type: Article

References (42)

1. Biecker E, De Gottardi A, Neef M, Unternahrer M, Schneider V, Ledermann M, Sagesser H, Shaw S, and Reichen J (2005) Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms. J Pharmacol Exp Ther 313:952-961.
2. Chawla A, Schwarz EJ, Dimaculangan DD, and Lazar MA (1994) Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135:798-800.
3. Chung JK, Kuo CJ, Crabtree GR, and Blenis J (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kD S6 protein kinases. Cell 69:1227-1236.
4. de Groot RP, Ballou LM, and Sassone-Corsi P (1994) Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 79:81-91.
5. Dubuquoy L, Dharancy S, Nutten S, Pettersson S, Auwerx J, and Desreumaux P (2002) Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet 360:1410-1418.
6. Friedman SL (1993) Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 328:1828-1835.
7. Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, et al. (2003) mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol 23:8862-8877.
8. Harada H, Andersen JS, Mann M, Terada N, and Korsmeyer SJ (2001) p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci USA 98:9666-9670.
9. Hazra S, Xiong S, Wang J, Rippe RA, Krishna V, Chatterjee K, and Tsukamoto H (2004) Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279:11392-11401.
10. Holmbeck SM, Foster MP, Casimiro DR, Sem DS, Dyson HJ, and Wright PE (1998) High-resolution solution structure of the retinoid X receptor DNA-binding domain. J Mol Biol 281:271-284.
11. IJpenberg A, Jeannin E, Wahli W, and Desvergne B (1997) Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem 272:20108-20117.
12. Jeno P, Ballou LM, Novak-Hofer I, and Thomas G (1988) Identification and characterization of a mitogen-activated S6 kinase. Proc Natl Acad Sci USA 85:406-410.
13. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
14. Kang KW, Choi SH, Ha JR, Kim CW, and Kim SG (2002) Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2- dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression. Chem Biol Interact 139:61-77.
15. Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, and Roberts AB (1990) Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol 10:1492-1497.
16. Kim SJ, Glick A, Sporn MB, and Roberts AB (1989a) Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem 264:402-408.
17. Kim SJ, Jeang KT, Glick AB, Sporn MB, and Roberts AB (1989b) Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction. J Biol Chem 264:7041-7045.
18. Kim Y, Ratziu V, Choi SG, Lalazar A, Theiss G, Dang Q, Kim SJ, and Friedman SL (1998) Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. J Biol Chem 273:33750-33758.
19. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, and Evans RM (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (Lond) 358:771-774.
20. Kon K, Ikejima K, Hirose M, Yoshikawa M, Enomoto N, Kitamura T, Takei Y, and Sato N (2002) Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride. Biochem Biophys Res Commun 291:55-61.
21. Kruse JJ, Bart CI, Leer JW, and Wondergem J (1999) Detection and quantitative measurement of transforming growth factor-beta1 (TGF-beta1) gene expression using a semi-nested competitive PCR assay. Cytokine 11:179-185.
22. Lee KS, Park SJ, Hwang PH, Yi HK, Song CH, Chai OH, Kim JS, Lee MK, and Lee YC (2005) PPAR-gamma modulates allergic inflammation through up-regulation of PTEN. FASEB J 19:1033-1035.
23. Lee KY, Ito K, Hayashi R, Jazrawi EP, Barnes PJ, and Adcock IM (2006) NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol 176:603-615.
24. Liu JL, Sheng X, Hortobagyi ZK, Mao Z, Gallick GE, and Yung WK (2005) Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol 25:6211-6224.
25. Marra F, DeFranco R, Robino G, Novo E, Efsen E, Pastacaldi S, Zamara E, Vercelli A, Lottini B, Spirli C, et al. (2005) Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis. World J Gastroenterol 11:4931-4938.
26. Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, Batignani G, Bonacchi A, Caporale R, Laffi G, Pinzani M, et al. (2000) Ligands of peroxisome proliferatoractivated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 119:466-478.
27. Mukherjee R, Jow L, Croston GE, and Paterniti JR Jr (1997) Identification, characterization and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists. J Biol Chem 272:8071-8076.
28. Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, et al. (2001) KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science (Wash DC) 294:2563-2566.
29. Oklu R and Hesketh R (2000) The latent transforming growth factor beta binding protein (LTBP) family. Biochem J 352:601-610.
30. Park EY, Cho IJ, and Kim SG (2004) Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. Cancer Res 64:3701-3713.
31. Patel L, Pass I, Coxon P, Downes CP, Smith SA, and Macphee CH (2001) Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol 11:764-768.
32. Pesce L, Comellas A, and Sznajder JI (2003) Beta-adrenergic agonists regulate Na-K-ATPase via p70S6K. Am J Physiol 285:L802-L807.
33. Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, Jensen S, and Friedman SL (1998) Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci USA 95:9500-9505.
34. Salbert G, Fanjul A, Piedrafita FJ, Lu XP, Kim SJ, Tran P, and Pfahl M (1993) Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity. Mol Endocrinol 7:1347-1356.
35. Skinner HD, Zheng JZ, Fang J, Agani F, and Jiang BH (2004) Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1α, HDM2 and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling. J Biol Chem 279:45643-45651.
36. Slavin DA, Koritschoner NP, Prieto CC, Lopez-Diaz FJ, Chatton B, and Bocco JL (2004) A new role for the Kruppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function. Oncogene 23:8196-8205.
37. Wang X, Li W, Williams M, Terada N, Alessi DR, and Proud CG (2001) Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO (Eur Mol Biol Organ) J 20:4370-4379.
38. Warke VG, Nambiar MP, Krishnan S, Tenbrock K, Geller DA, Koritschoner NP, Atkins JL, Farber DL, and Tsokos GC (2003) Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. J Biol Chem 278:14812-14819.
39. Weigert C, Brodbeck K, Bierhaus A, Haring HU, and Schleicher ED (2003) c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinediones. Biochem Biophys Res Commun 304:301-307.
40. Weigert C, Sauer U, Brodbeck K, Pfeiffer A, Haring HU, and Schleicher ED (2000) AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells. J Am Soc Nephrol 11:2007-2016.
41. Zhang XK, Hoffmann B, Tran PB, Graupner G, and Pfahl M (1992) Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (Lond) 355:441-446.
42. Zhu J, Wu J, Frizell E, Liu SL, Bashey R, Rubin R, Norton P, and Zern MA (1999) Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 117:1198-1204.