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Volumn 13, Issue 1, 2011, Pages 42-45

Microwave-assisted solvent- and ligand-free copper-catalysed cross-coupling between halopyridines and nitrogen nucleophiles

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EID: 78651269921     PISSN: 14639262     EISSN: 14639270     Source Type: Journal    
DOI: 10.1039/c0gc00296h     Document Type: Article
Times cited : (66)

References (71)
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    • It should be, however, noted that solvent-free exothermic reactions can be problematic because a thermal buffer is missing. For a related study, see
    • It should be, however, noted that solvent-free exothermic reactions can be problematic because a thermal buffer is missing. For a related study, see: L. Balland N. Mouhab J.-M. Cosmao L. Estel Chem. Eng. Proc. 2002 41 395.
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    • (2006) Microwaves in Organic Synthesis
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    • For other copper-catalysed N-heteroarylations of nitrogen nucleophiles with heteroaryl halides, see
    • For other copper-catalysed N-heteroarylations of nitrogen nucleophiles with heteroaryl halides, see: D. Cheng F. Gan W. Qian W. Bao Green Chem. 2008 10 171.
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    • The MW experiments, the temperature was measured by an internal thermocouple. The setting power of the MW instrument was 50 W during the entire reaction time. When the temperature reached 100 °C, the instrument automatically adjusted the power to maintain this temperature
    • In the MW experiments, the temperature was measured by an internal thermocouple. The setting power of the MW instrument was 50 W during the entire reaction time. When the temperature reached 100 °C, the instrument automatically adjusted the power to maintain this temperature.
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    • For recent mechanistic studies on copper-catalysed cross-couplings, see
    • For recent mechanistic studies on copper-catalysed cross-couplings, see: E. R. Strieter B. Bhayana S. L. Buchwald J. Am. Chem. Soc. 2009 131 78.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 78
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    • Sulfoximines have been found to be effective chiral ligands in several catalytic asymmetric reactions by our group. For recent examples, see
    • Sulfoximines have been found to be effective chiral ligands in several catalytic asymmetric reactions by our group. For recent examples, see: M. Frings I. Atodiresei J. Runsink G. Raabe C. Bolm Chem. Eur. J. 2009 15 1566.
    • (2009) Chem. Eur. J. , vol.15 , pp. 1566
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    • 3, 100 °C, MW (50 W), 1 h] can also be applied in the coupling between phenyl iodide and S-methyl-S-phenylsulfoximine to give the corresponding N-arylated product in 72% yield
    • 3, 100 °C, MW (50 W), 1 h] can also be applied in the coupling between phenyl iodide and S-methyl-S-phenylsulfoximine to give the corresponding N-arylated product in 72% yield.


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