Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis

Phytomedicine

Volumn 18, Issue 2-3, 2011, Pages 176-185

  Hsieh, Tsai Pei ^a   Sheu, Shiow Yunn ^a   Sun, Jui Sheng ^a,b   Chen, Ming Hong ^c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b Hsin Chu General Hospital   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Epimedium pubescens; Gene expression; HIF 1 ; Icariin; LPS; MAPKs; NF B; Osteoclast

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B ALPHA; ICARIIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; GENE EXPRESSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UPREGULATION;

ANIMALS; BONE RESORPTION; CELL DIFFERENTIATION; CYCLOOXYGENASE 2; DINOPROSTONE; EPIMEDIUM; FEMALE; FLAVONOIDS; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OSTEOCLASTS; OSTEOLYSIS; OSTEOPOROSIS; OSTEOPROTEGERIN; PLANT EXTRACTS; RANK LIGAND; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EPIMEDIUM PUBESCENS;

EID: 78651263812     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.04.003     Document Type: Article

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