Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide

Clinical and Experimental Immunology

Volumn 149, Issue 2, 2007, Pages 327-334

  Kiji, M ^a   Nagasawa, T ^a   Hormdee, D ^b   Yashiro, R ^a   Kobayashi, H ^a   Noguchi, K ^a   Nitta, H ^a   Izumi, Y ^c   Ishikawa, I ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KHON KAEN UNIVERSITY   (Thailand)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

HGF; LPS; OPG; Periodontitis; PGE2

Indexed keywords

CELL EXTRACT; EP1 AGONIST; EP2 AGONIST; EP3 AGONIST; EP4 AGONIST; INDOMETACIN; LIPOPOLYSACCHARIDE; OSTEOPROTEGERIN; POLYMYXIN B; PROSTAGLANDIN E2; PROSTAGLANDIN INHIBITOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FLOW CYTOMETRY; GINGIVA; HUMAN; HUMAN CELL; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELLS, CULTURED; CHRONIC DISEASE; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GINGIVA; HUMANS; LIPOPOLYSACCHARIDES; OSTEOPROTEGERIN; PERIODONTITIS; RECEPTORS, PROSTAGLANDIN E; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 34447526576     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03414.x     Document Type: Article

References (44)

1. Medzhitov R, Janeway CA Jr. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997 91 : 295 8.
2. Mayrand D, Holt SC. Biology of asaccharolytic black-pigmented Bacteroides species. Microbiol Rev 1988 52 : 134 52.
3. Netea MG, van Deuren M, Kullberg BJ, Cavaillon JM, Van der Meer JW. Does the shape of lipid A determine the interaction of LPS with Toll-like receptors? Trends Immunol 2002 23 : 135 9.
4. Masoud H, Weintraub ST, Wang R, Cotter R, Holt SC. Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y4 and human clinical isolate PO 1021-7. Eur J Biochem 1991 200 : 775 81.
5. Lee SH, Kim KK, Rhyu IC, Koh S, Lee DS, Choi BK. Phenol/water extract of Treponema socranskii subsp. socranskii as an antagonist of Toll-like receptor 4 signalling. Microbiology 2006 152 : 535 46.
6. Hirschfeld M, Weis JJ, Toshchakov V et al. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001 69 : 1477 82.
7. Kong YY, Boyle WJ, Penninger JM. Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunol Today 2000 21 : 495 502.
8. Katagiri T, Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 2002 8 : 147 59.
9. Nagasawa T, Kobayashi H, Kiji M et al. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin Exp Immunol 2002 130 : 338 44.
10. Nagasawa T, Kiji M, Yashiro R et al. Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontal 2007 43 : 65 84.
11. DeWitt DL. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1991 1083 : 121 34.
12. Tilley SL, Coffman TM, Koller BH. Mixed messages. modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 2001 108 : 15 23.
13. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties and functions. Physiol Rev 1999 79 : 1193 226.
14. Negishi M, Sugimoto Y, Ichikawa A. Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1995 1259 : 109 19.
15. Offenbacher S, Heasman PA, Collins JG. Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J Periodontol 1993 64 (5 Suppl. 432 44.
16. Noguchi K, Ishikawa I. The roles of cyclooxygenase-2 and prostaglandin E in periodontal disease. Periodontology 2000 2007 43 : 85 101.
17. Hwang D. Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways. FASEB J 2001 15 : 2556 64.
18. Sakata M, Shiba H, Komatsuzawa H et al. Osteoprotegerin levels increased by interleukin-1beta in human periodontal ligament cells are suppressed through prostaglandin E(2) synthesized de novo. Cytokine 2002 18 : 133 9.
19. Suda K, Udagawa N, Sato N et al. Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide- induced osteoclast formation. J Immunol 2004 172 : 2504 10.
20. Wang D, Kawashima Y, Nagasawa T et al. Elevated serum IgG titer and avidity to Actinobacillus actinomycetemcomitans serotype c in Japanese periodontitis patients. Oral Microbiol Immunol 2005 20 : 172 9.
21. Kubo K, Kamada T, Okamoto H, Izumi Y, Otsuji S, Sueda T. Lipopolysaccharide increases cell surface-associated fibronectin in fibroblasts in vitro. Oral Microbiol Immunol 1996 11 : 29 34.
22. Westphal O, Jann K. Bacterial lipopolysaccharides: extraction with phenol water and further application of the procedure. Meth Carbohydr Chem 1965 5 : 83 91.
23. Hiraoka T, Izumi Y, Sueda T. Immunochemical detection of CD14 on human gingival fibroblasts in vitro. Oral Microbiol Immunol 1998 13 : 246 52.
24. Kobayashi H, Nagasawa T, Aramaki M, Mahanonda R, Ishikawa I. Individual diversities in interferon gamma production by human peripheral blood mononuclear cells stimulated with periodontopathic bacteria. J Periodont Res 2000 35 : 319 28.
25. Noguchi K, Shitashige M, Yanai M et al. Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides. Inflammation 1996 20 : 555 68.
26. Weinreb M, Suponitzky I, Keila S. Systemic administration of an anabolic dose of PGE2 in young rats increases the osteogenic capacity of bone marrow. Bone 1997 20 : 521 6.
27. Ono K, Akatsu T, Murakami T et al. Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. J Bone Miner Res 2002 17 : 774 81.
28. Liu XH, Kirschenbaum A, Yao S, Levine AC. Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{kappa}B (RANK) ligand/RANK system. Endocrinology 2005 146 : 1991 8.
29. Harris SG, Padilla J, Koumas L, Ray D, Phipps RP. Prostaglandins as modulators of immunity. Trends Immunol 2002 23 : 144 50.
30. Noguchi K, Shitashige M, Endo H, Kondo H, Ishikawa I. Binary regulation of interleukin (IL)-6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1beta-stimulated human gingival fibroblasts. J Periodont Res 2002 37 : 29 36.
31. Ohnishi A, Shimamoto C, Katsu K, Ito S, Imai Y, Nakahari T. EP1 and EP4 receptors mediate exocytosis evoked by prostaglandin E(2) in guinea-pig antral mucous cells. Exp Physiol 2001 86 : 451 60.
32. Takami M, Takahashi N, Udagawa N et al. Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 2000 141 : 4711 9.
33. Kondo H, Guo J, Bringhurst FR. Cyclic adenosine monophosphate/protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells. J Bone Miner Res 2002 17 : 1667 79.
34. Regan JW. EP2 and EP4 prostanoid receptor signaling. Life Sci 2003 74 : 143 53.
35. Hormdee D, Nagasawa T, Kiji M et al. Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts. Clin Exp Immunol 2005 142 : 490 7.
36. Heath JK, Atkinson SJ, Hembry RM, Reynolds JJ, Meikle MC. Bacterial antigens induce collagenase and prostaglandin E2 synthesis in human gingival fibroblasts through a primary effect on circulating mononuclear cells. Infect Immun 1987 55 : 2148 54.
37. Sismey-Durrant HJ, Hopps RM. Effect of lipopolysaccharide from Porphyromonas gingivalis on prostaglandin E2 and interleukin-1-beta release from rat periosteal and human gingival fibroblasts in vitro. Oral Microbiol Immunol 1991 6 : 378 80.
38. Wang PL, Azuma Y, Shinohara M, Ohura K. Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts. Biochem Biophys Res Commun 2000 273 : 1161 7.
39. Teng YT, Nguyen H, Gao X et al. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest 2000 106 : R59 67.
40. Mahamed DA, Marleau A, Alnaeeli M et al. G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes 2005 54 : 1477 86.
41. Kawai T, Matsuyama T, Hosokawa Y et al. B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 2006 169 : 987 98.
42. Nukaga J, Kobayashi M, Shinki T et al. Regulatory effects of interleukin-1beta and prostaglandin E2 on expression of receptor activator of nuclear factor-kappaB ligand in human periodontal ligament cells. J Periodontol 2004 75 : 249 59.
43. de Vries TJ, Schoenmaker T, Wattanaroonwong N et al. Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J Cell Biochem 2006 98 : 370 82.
44. Lindhe J, Karring T, Lang PN. Clinical periodontology and implant dentistry, 4th edn. Copenhagen : Blackwell Munksgaard, 2003.