A p38α selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 1, 2007, Pages 56-63

  Kirkwood, Keith L ^a   Li, Fei ^a   Rogers, Jill E ^a   Otremba, Jodie ^a   Coatney, Derek D ^a   Kreider, Jaclynn M ^a   D'Silva, Nisha J ^a,b   Chakravarty, Sarvajit ^c   Dugar, Sundeep ^c   Higgins, Linda S ^c   Protter, Andrew A ^c   Medicherla, Satyanarayana ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c SCIOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; SD 282; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; INDOLE 5 CARBOXAMIDE; INDOLE DERIVATIVE; INDOLE-5-CARBOXAMIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DESTRUCTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MAXILLA; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PERIODONTAL DISEASE; PERIODONTITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; VOLUMETRY; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ALVEOLAR BONE LOSS; ANIMALS; CYTOKINES; FEMALE; INDOLES; LIPOPOLYSACCHARIDES; OSTEOCLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERIODONTITIS; PROTEIN KINASE INHIBITORS; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33845874434     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.112466     Document Type: Article

References (41)

1. Adams JL, Badger AM, Kumar S, and Lee JC (2001) p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines. Prog Med Chem 38:1-60.
2. Assuma R, Oates T, Cochran D, Amar S, and Graves DT (1998) IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol 160:403-409.
3. Aubin JE and Bonnelye E (2000) Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Medscape Womens Health 5:5.
4. Baker PJ (2000) The role of immune responses in bone loss during periodontal disease. Microbes Infect 2:1181-1192.
5. Chen CC, Chang KL, Huang JF, Huang JS, and Tsai CC (1998) Interleukin-6 production by human gingival fibroblasts following stimulation with Actinobacillus actinomycetemcomitans. Kaohsiung J Med Sci 14:367-378.
6. Crotti T, Smith MD, Hirsch R, Soukoulis S, Weedon H, Capone M, Ahern MJ, and Haynes D (2003) Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis. J Periodontal Res 38:380-387.
7. Dai JC, He P, Chen X, and Greenfield EM (2006) TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics. Bone (NY) 38:509-520.
8. Ejeil AL, Gaultier F, Igondjo-Tchen S, Senni K, Pellat B, Godeau G, and Gogly B (2003) Are cytokines linked to collagen breakdown during periodontal disease progression? J Periodontol 74:196-201.
9. Graves DT (1999) The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clin Infect Dis 28:482-490.
10. Graves DT and Cochran D (2003) The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 74:391-401.
11. Greenwald RA and Kirkwood K (1999) Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies). J Rheumatol 26:1650-1653.
12. Hofbauer LC and Heufelder AE (2001) Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 79:243-253.
13. Hoffmann E, Dittrich-Breiholz O, Holtmann H, and Kracht M (2002) Multiple control of interleukin-8 gene expression. J Leukoc Biol 72:847-855.
14. Holtmann H, Winzen R, Holland P, Eickemeier S, Hoffmann E, Wallach D, Malinin NL, Cooper JA, Resch K, and Kracht M (1999) Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Mol Cell Biol 19:6742-6753.
15. Ishida A, Fujita N, Kitazawa R, and Tsuruo T (2002) Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone. J Biol Chem 277:26217-26224.
16. Kirkwood K, Cirelli J, Rogers JE, and Giannobile WV (2006) Novel host response therapeutic approaches to treat periodontal diseases. Periodontol 2000, in press.
17. Kirkwood K, Martin T, Andreadis ST, and Kim YJ (2003) Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability. Biochem Pharmacol 66:1809-1819.
18. Kostenuik PJ, Bolon B, Morony S, Daris M, Geng Z, Carter C, and Sheng J (2004) Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice. Bone (NY) 34:656-664.
19. Lee HJ, Kang IK, Chung CP, and Choi SM (1995) The subgingival microflora and gingival crevicular fluid cytokines in refractory periodontitis. J Clin Periodontol 22:885-890.
20. Lee JC, Kumar S, Griswold DE, Underwood DC, Votta BJ, and Adams JL (2000) Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology 47:185-201.
21. Madianos PN, Bobetsis YA, and Kinane DF (2005) Generation of inflammatory stimuli: how bacteria set up inflammatory responses in the gingiva. J Clin Periodontol 32 (Suppl 6):57-71.
22. Matsumoto M, Sudo T, Saito T, Osada H, and Tsujimoto M (2000) Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem 275:31155-31161.
23. Medicherla S, Ma JY, Mangadu R, Jiang Y, Zhao JJ, Almirez R, Kerr I, Stebbins EG, O'Young G, Kapoun AM, et al. (2006) A selective p38 mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis. J Pharmacol Exp Ther 318:132-141.
24. Mercado FB, Marshall RI, and Bartold PM (2003) Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J Clin Periodontol 30:761-772.
25. Page RC (1991) The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 26:230-242.
26. Patil C, Rossa C Jr, and Kirkwood KL (2006) A. actinomycetemcomitans LPS induces IL-6 expression through multiple MAPK pathways in periodontal ligament fibroblasts. Oral Microbiol Immunol 21:392-398.
27. Patil C, Zhu X, Rossa C Jr, Kim YJ, and Kirkwood KL (2004) p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts. Immunol Investig 33:213-233.
28. Reddi K, Wilson M, Nair S, Poole S, and Henderson B (1996) Comparison of the pro-inflammatory cytokine-stimulating activity of the surface-associated proteins of periodontopathic bacteria. J Periodontal Res 31:120-130.
29. Rodan GA and Martin TJ (2000) Therapeutic approaches to bone diseases. Science (Wash DC) 289:1508-1514.
30. Rogers JE, Li F, Coatney DD, Rossa C Jr, Bronson P, Kriegl J, Giannobile WV, and Kirkwood KL (2006) Actinobacillus actinomycetemcomitans LPS induces inflammatory bone loss in rats: a model for aggressive periodontitis. J Periodontol, in press.
31. Rossa C Jr, Ehman K, Liu M, Patil C, and Kirkwood K (2006) MKK3/6-p38 MAPK signaling is required for IL-1β and TNF-α induced RANKL expression in bone marrow stromal cells. J Interferon Cytokine Res 26:719-729.
32. Rossa C Jr, Liu M, Patil C, and Kirkwood KL (2005) MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts. Matrix Biol 24:478-488.
33. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309-319.
34. Slots J and Ting M (1999) Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000 20:82-121.
35. Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, and Socransky SS (1991) Tissue levels of bone resorptive cytokines in periodontal disease. J Periodontol 62:504-509.
36. Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, Ellen RP, and Penninger JM (2000) Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Investig 106:R59-R67.
37. Tsai CC, Ho YP, and Chen CC (1995) Levels of interleukin-1 beta and interleukin-8 in gingival crevicular fluids in adult periodontitis. J Periodontol 66:852-859.
38. Wei S, Kitaura H, Zhou P, Ross FP, and Teitelbaum SL (2005) IL-1 mediates TNF-induced osteoclastogenesis. J Clin Investig 115:282-290.
39. Wilensky A, Gabet Y, Yumoto H, Houri-Haddad Y, and Shapira L (2005) Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography. J Periodontol 76:1282-1286.
40. Williams RC (1990) Periodontal disease. N Engl J Med 322:373-382.
41. Wilson ME and Hamilton RG (1992) Immunoglobulin G subclass response of localized juvenile periodontitis patients to Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide. Infect Immun 60:1806-1812.