Lysophosphatidic acid-induced ERK activation and chemotaxis in MC3T3-E1 preosteoblasts are independent of EGF receptor transactivation

Journal of Cellular Physiology

Volumn 219, Issue 3, 2009, Pages 716-723

  Karagiosis, Sue A ^a   Chrisler, William B ^a   Bollinger, Nikki ^a   Karin, Norman J ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; EPIDERMAL GROWTH FACTOR RECEPTOR; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; RAS PROTEIN; LYSOPHOSPHOLIPID; MITOGEN ACTIVATED PROTEIN KINASE; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE CELL; BONE REMODELING; CELL MIGRATION; CELL MOTILITY; CELL NUCLEUS; CELL STRAIN 3T3; CELL TYPE; CHEMOTAXIS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IN VIVO CULTURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL MOTION; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSCRIPTION INITIATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CELL MOVEMENT; CHEMOTAXIS; DNA PRIMERS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LYSOPHOSPHOLIPIDS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOBLASTS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 64549161581     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21720     Document Type: Article

References (40)

1. 2+, and calmodulin. Cell Signal 14:649-654.
2. Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM. 2003. Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2α-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. Molecular Endocrinology 17:1607-1621. (Pubitemid 36930474)
3. Ando R, Mizuno H, Miyawaki A. 2004. Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting. Science 306:1370-1373. (Pubitemid 39532513)
4. Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH, Schlessinger J. 2001. Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 276:20130-20135. (Pubitemid 37411084)
5. Anliker B, Chun J. 2004. Cell surface receptors in lysophospholipid signaling. Semin Cell Dev Biol 15:457-465. (Pubitemid 38953942)
6. Caverzasio J, Palmer G, Suzuki A, Bonjour JP. 2000. Evidence for the involvement of two pathways in activation of extracellular signal-regulated kinase (Erk) and cell proliferation by Gi and Gq protein-coupled receptors in osteoblast-like cells. J Bone Miner Res 15:1697-1706. (Pubitemid 30666224)
7. Chen RH, Sarnecki C, Blenis J. 1992. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 12:915-927.
8. Chuderland D, Konson A, Seger R. 2008. Identification and characterization of a general nuclear translocation signal in signaling proteins. Mol Cell 31:850-861.
9. A1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci USA 97:13384-13389.
10. Costa M, Marchi M, Cardarelli F, Roy A, Beltram F, Maffei L, Ratto GM. 2006. Dynamic regulation of ERK2 nuclear translocation and mobility in living cells. J Cell Sci 119:4952-4963. (Pubitemid 46017808)
11. Dickinson RJ, Keyse SM. 2006. Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci 119:4607-4615. (Pubitemid 44964257)
12. Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH. 1993. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J 291:677-680. (Pubitemid 23148436)
13. Einhorn TA. 1998. The cell and molecular biology of fracture healing. Clin Orthop Relat Res 355:S7-S21. (Pubitemid 28538514)
14. Garton KJ, Ferri N, Raines EW. 2002. Efficient expression of exogenous genes in primary vascular cells using IRES-based retroviral vectors. Biotechniques 32:830, 832, 834 passim. (Pubitemid 34298711)
15. Grey A, Banovic T, Naot D, Hill B, Callon K, Reid I, Cornish J. 2001. Lysophosphatidic acid is an osteoblast mitogen whose proliferative actions involve Gi proteins and protein kinase C, but not P42/44 mitogen-activated protein kinases. Endocrinology 142:1098-1106. (Pubitemid 32202819)
16. Grey A, Chen Q, Callon K, Xu X, Reid IR, Cornish J. 2002. The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving Gi proteins and phosphatidylinositol-3 kinase. Endocrinology 143:4755-4763. (Pubitemid 35397617)
17. Harrison SM, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, Hemmati P, Hervieu G, Howarth A, Hughes ZA, Hunter AJ, Latcham J, Pickering S, Pugh P, Rogers DC, Shilliam CS, Maycox PR. 2003. LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Mol Cell Neurosci 24:1170-1179. (Pubitemid 38091524)
18. Hecht JH, Weiner JA, Post SR, Chun J. 1996. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 135:1071-1083. (Pubitemid 26403779)
19. Huang C, Jacobson K, Schaller MD. 2004. MAP kinases and cell migration. J Cell Sci 117:4619-4628. (Pubitemid 39433429)
20. Ishii I, Fukushima N, Ye X, Chun J. 2004. Lysophospholipid receptors: Signaling and biology. Annu Rev Biochem 73:321-354. (Pubitemid 39050372)
21. Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912. (Pubitemid 35425238)
22. Karagiosis SA, Karin NJ. 2007. Lysophosphatidic acid induces osteocyte dendrite outgrowth. Biochem Biophys Res Commun 357:194-199. (Pubitemid 46574515)
23. Katz RW, Teng SY, Thomas S, Landesberg R. 2002. Paracrine activation of extracellular signal-regulated kinase in a simple in vitro model of wounded osteoblasts. Bone 31:288-295. (Pubitemid 34814963)
24. Kholodenko BN. 2006. Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol 7:165-176. (Pubitemid 43297946)
25. Kitamura T, Onishi M, Kinoshita S, Shibuya A, Miyajima A, Nolan GP. 1995. Efficient screening of retroviral cDNA expression libraries. Proc Natl Acad Sci USA 92:9146-9150.
26. Krebsbach PH, Harrison JR, Lichtler AC, Woody CO, Rowe DW, Kream BE. 1993. Transgenic expression of COL1A1-chloramphenicol acetyltransferase fusion genes in bone: Differential utilization of promoter elements in vivo and in cultured cells. Mol Cell Biol 13:5168-5174. (Pubitemid 23956568)
27. 2+ signaling in MC3T3-E1 osteoblastic cells. J Bone Miner Res 16:2035-2042.
28. Masiello LM, Fotos JS, Galileo DS, Karin NJ. 2006. Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells. Bone 39:72-82. (Pubitemid 43831774)
29. Matsubayashi Y, Ebisuya M, Honjoh S, Nishida E. 2004. ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol 14:731-735. (Pubitemid 38503612)
30. Mills GB, Moolenaar WH. 2003. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 3:582-591. (Pubitemid 37328830)
31. Montiel M, de la Blanca EP, Jimenez E. 2006. P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. Cell Physiol Biochem 18:123-134. (Pubitemid 44242794)
32. Moolenaar WH, van Meeteren LA, Giepmans BN. 2004. The ins and outs of lysophosphatidic acid signaling. Bioessays 26:870-881. (Pubitemid 39128101)
33. Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Nishitoba T, Im DS, Nochi H, Tamoto K, Tomura H,Okajima F. 2003. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol 64:994-1005. (Pubitemid 37153068)
34. Panupinthu N, Rogers JT, Zhao L, Solano-Flores LP, Possmayer F, Sims SM, Dixon SJ. 2008. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: A signaling axis promoting osteogenesis. J Cell Biol 181:859-871.
35. Schindeler A, Little DG. 2006. Ras-MAPK signaling in osteogenic differentiation: Friend or foe? J Bone Miner Res 21:1331-1338.
36. Sharrocks AD. 2006. Cell cycle: Sustained ERK signalling represses the inhibitors. Curr Biol 16:R540-R542. (Pubitemid 44066782)
37. Tsiridis E, Upadhyay N, Giannoudis P. 2007. Molecular aspects of fracture healing: Which are the important molecules? Injury 38:S11-S25.
38. Waters KM, Tan R, Genetos DC, Verma S, Yellowley CE, Karin NJ. 2007. DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells. Bone 41:833-841. (Pubitemid 47576839)
39. Weiner JA, Hecht JH, Chun J. 1998. Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 398:587-598. (Pubitemid 28364536)
40. Wu J, Cunnick JM. 2002. Trans-regulation of epidermal growth factor receptor by lysophosphatidic acid and G protein-coupled receptors. Biochim Biophys Acta 1582:100-106. (Pubitemid 34634117)