The synthesis and biological evaluation of 1-C-alkyl-l- arabinoiminofuranoses, a novel class of α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 738-741

  Natori, Yoshihiro ^a   Imahori, Tatsushi ^a   Murakami, Keiichi ^a   Yoshimura, Yuichi ^a   Nakagawa, Shinpei ^b   Kato, Atsushi ^b   Adachi, Isao ^b   Takahata, Hiroki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Glucosidase inhibitor; 1 C Alkyl l arabinoiminofuranose; Asymmetric allylic alkylation; Negishi cross coupling; Type 2 diabetes

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; ARABINOIMINOFURANOSE DERIVATIVE; MIGLITOL; UNCLASSIFIED DRUG; VOGLIBOSE;

ALKYLATION; ARTICLE; ASYMMETRIC SYNTHESIS; CROSS COUPLING REACTION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; RING CLOSING METATHESIS;

ALPHA-GLUCOSIDASES; ANIMALS; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; IMINO FURANOSES; RATS;

EID: 78651247063     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.112     Document Type: Article

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