Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 1810-1813

  Ohara, Chiaki ^a   Takahashi, Ryouko ^a   Miyagawa, Tatsunori ^a   Yoshimura, Yuichi ^a   Kato, Atsushi ^b   Adachi, Isao ^b   Takahata, Hiroki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

3 Hydroxy 4,5 dehydropipecolic acid; 3 Hydroxypipecolic acid; Glycosidase inhibitor: uronic acid

Indexed keywords

3 HYDROXY 4,5 DEHYDROPIPECOLIC ACID; 3 HYDROXYPIPECOLIC ACID; ALPHA N ACETYLGALACTOSAMINIDASE; BETA GLUCURONIDASE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; N ACETYL BETA GLUCOSAMINIDASE; PIPECOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATTLE; CHICKEN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; GLYCOSIDATION; HUMAN; IC 50; LIVER; NONHUMAN; PLACENTA; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ACETYLGLUCOSAMINIDASE; ALPHA-N-ACETYLGALACTOSAMINIDASE; ANIMALS; CATTLE; CHICKENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUCURONIDASE; HUMANS; KIDNEY; LIVER; MASS SPECTROMETRY; PIPECOLIC ACIDS; PLACENTA; STEREOISOMERISM;

ESCHERICHIA COLI;

EID: 40749113116     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.028     Document Type: Article

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