2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3790-3794

  Kato, Atsushi ^a   Yamashita, Yukiko ^a   Nakagawa, Shinpei ^a   Koike, Yuriko ^a   Adachi, Isao ^a   Hollinshead, Jackie ^b   Nash, Robert J ^b   Ikeda, Kyoko ^c   Asano, Naoki ^c  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Phytoquest Limited   (United Kingdom)

^c HOKURIKU UNIVERSITY   (Japan)

Author keywords

Galactosidase A; 2,5 Dideoxy 2,5 imino d altritol; Adenophora triphylla; Glycosidase inhibitor; Pharmacological chaperone

Indexed keywords

2,3 DIDEOXY BETA 1 C ETHYL 1 DEOXYGALACTONOJIRIMYCIN; 2,5 DIDEOXY 2,5 IMINO DEXTRO ALTRITOL; 6 O BETA DEXTRO GLUCOPYRANOSYL 2,3 DIDEOXY BETA 1 C ETHYL 1 DEOXYGALACTONOJIRIMYCIN; ALPHA GALACTOSIDASE; BETA 1 C BUTENYL 1 DEOXY 1 GALACTONOJIRIMYCIN; BETA 1 C BUTYL 1 DEOXYGALACTONOJIRIMYCIN; CHAPERONE; ENZYME INHIBITOR; IMINOSUGAR; N BUTYL 1 DEOXYGALACTONOJIRIMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPETITIVE INHIBITION; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FABRY DISEASE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LYMPHOBLAST; LYSOSOME; MUTANT; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITY CONTROL; THERMOSTABILITY; TRANSPORT KINETICS;

ALPHA-GALACTOSIDASE; CAMPANULACEAE; FABRY DISEASE; HUMANS; IMINO SUGARS; MOLECULAR CHAPERONES; MUTANT PROTEINS; PHYTOTHERAPY; PIPERIDINES; PLANT EXTRACTS; PROTEIN TRANSPORT; PYRROLIDINES; SUGAR ALCOHOLS;

ADENOPHORA TRIPHYLLA;

EID: 77953127358     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.048     Document Type: Article

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