Cisplatin biochemical mechanism of action: From cytotoxity to induction of cell death through interconnections between apoptotic and necrotic pathways

Current Medicinal Chemistry

Volumn 10, Issue 3, 2003, Pages 257-266

  Fuertes, M A ^a   Castilla, J ^b   Alonso, C ^a   Perez J M ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Farmacia Castilla   (Spain)

Author keywords

Antitumor activity; Apoptosis; Cell death; Cisplatin; Necrosis

Indexed keywords

AMPHOTERICIN B; ANTINEOPLASTIC AGENT; CARBOPLATIN; CASPASE; CELL NUCLEUS DNA; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOCHROME C; DIGITONIN; DNA; DOXORUBICIN; GLUTATHIONE; GUANINE; HIGH MOBILITY GROUP A PROTEIN; MITOMYCIN C; NEDAPLATIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLIGONUCLEOTIDE; OXALIPLATIN; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PLATINUM DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; SULFUR; TATA BINDING PROTEIN; UBIQUITIN; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BINDING SITE; BLADDER TUMOR; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CELL MEMBRANE; CELL METABOLISM; CYTOPLASM; CYTOTOXICITY; DNA REPLICATION; DNA TRANSCRIPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; GENE TARGETING; HEAD AND NECK TUMOR; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; NEPHROTOXICITY; NEUROTOXICITY; OTOTOXICITY; OVARY TUMOR; REVIEW; TESTIS TUMOR;

EID: 12244262808     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033368484     Document Type: Review

References (78)

1. Peyrone, M. Ann. Chem. Pharm. 1845, 51, 1.
2. Rosenberg, B.; Van Camp, L.; Krigas, T. Nature 1965, 205, 698.
3. Rosenberg, B.; Van Camp, L.; Trosko, J.E.; Mansour, V.H. Nature 1969, 222, 385.
4. Wong, E.; Giandomenico, C.M. Chem. Rev. 1999, 99, 2451.
5. Judson, I.; Kelland, L.R. Drugs 2000, 59, 29.
6. Fuertes, M.A.; Castilla, J.; Alonso, C.; Pérez, J.M. Curr. Med. Chem.-Anti-Cancer Agents 2002, 2, 539.
7. Jamieson, E.R.; Lippard, S.J. Chem. Rev. 1999, 99, 2467.
8. Pérez, R.P. Eur. J. Cancer 1998, 34, 1535.
9. Gately D.P.; Howell, S.B. Br. J. Cancer 1993, 67, 1171.
10. Andrews, P.A. In Platinum-Based Drugs in Cancer Therapy; Kelland L.R., Farrell N.P., Ed.; Totowa: Humana Press, 2000. pp. 89-113.
11. Miller, S.E., House, D.A. Inorg. Chim. Acta 1991, 187, 125.
12. Speelmans, G.; Staffhorst, R. W. H. M.; Versluis, K.; Reedijk, J.; de Kruijff, B. Biochemistry 1997, 36, 10545.
13. Jordan, P.; Carmo-Fonseca, M. Cell. Mol. Life Sci. 2000, 57, 1229.
14. Reedijk, J. Chem. Rev. 1999, 99, 2499.
15. Ishikawa, T.; Ali-Osman, F. J. Biol. Chem. 1993, 268, 20116.
16. Louie, A. Y.; Meade, T. J. Chem. Rev. 1999, 99, 2711.
17. Söti, C.; Rácz, A.; Csermely, P. J. Biol. Chem. 2002, 277, 7066.
18. Yang, X-L.; Wang, A.H-J. Pharmacol. Therapeut. 1999, 83, 181-215.
19. Payet, D.; Gaucheron, F.; Sip, M.; Leng, M. Nucleic Acids Res. 1993, 21, 5846.
20. Barnham, K. J.; Berners-Price, S. J.; Frenkiel, T. A.; Frey, U.; Sadler, P. J. Angew. Chem.-Int. Edit. Engl. 1995, 34, 1874.
21. Auge, P.; Kozelka, J. Transit. Met. Chem. 1997, 22, 91.
22. Natile, G.; Coluccia, M. Coord. Chem. Rev. 2001, 216, 383.
23. Cohen, G.L.; Ledner, J.A.; Bauer, W.R.; Ushay H.M.; Caravana, C.; Lippard., S.J. J. Am. Chem. Soc. 1980, 102, 2487.
24. Caradonna, J.P.; Lippard, S.J.; Gait, M.J.; Singh, M. J. Am. Chem. Soc. 1982, 104, 5793.
25. Pérez, J.M.; Fuertes, M.A.; Alonso, C.; Navarro-Ranninger, C. Crit. Rev. Oncol/Hematol. 2000, 35, 109.
26. Pil, P.M.; Lippard, S.J. Science 1992, 256, 234.
27. Mu, D.; Shu, D.S.; Sancar, A. J. Biol. Chem. 1996, 271, 8285.
28. Gonzalez, V.M.; Fuertes, M.A.; Alonso, C.; Pérez, J.M. Mol. Pharmacol. 2001, 59, 657.
29. Malinge, J-M.; Giraud-Panis, M-J.; Leng, M. J. Inorg. Biochem. 1999, 77, 23.
30. Hartley, J.M.; Spanswick, V.J.; Gander, M.; Giacomini, G.; Whelan, J.; Souhami, R.L.; Hartley, J.A. Clin. Cancer Res. 1999, 5, 507.
31. Petersen, L.N.; Mamenta, E.L.; Stevsner, T.; Chaney, S.G.; Bohr, V.A. Carcinogenesis 1996, 17, 2597.
32. Bruhn, S.L.; Pil, P.M.; Essigmann, J.M.; Housman, D.E.; Lippard, S.J. Proc. Natl. Acad. Sci. USA 1992, 89, 2307.
33. Yamada, M.; O'Regan, E.; Brown, R.; Karrap, P. Nucleic Acids Res. 1997, 25, 491.
34. Reed, E. In Cancer Chemotherapy and Biological Response Modifiers. Pinedo, H.M., Longo, D.L., and Chabner, B.A., Ed.; Elsevier Science BV, Amsterdan. 1999, pp. 144-151.
35. Turchi, J.J.; Henkels, K.M. J. Biol. Chem. 1996, 271, 13861.
36. Henkels, K.M.; Turchi, J.J. Cancer Res. 1997, 57, 4488.
37. Yarnell, A.T.; Oh, S.; Reinberg, D.; Lippard, S.J. J. Biol. Chem. 2001, 276, 25736.
38. Cohen, S.M.; Lippard, S.J. Prog. Nucleic Acids Res. Mol. Biol. 2001, 67, 93.
39. Zamble, D.B.; Lippard, S.J. In Cisplatin, Chemistry and Biochemistry of a Leading Anticancer Drug; Lippert, B., Ed.; Wiley-VCH, Base, Switzerland, 1999. pp. 339-362.
40. Brown, S.J.; Kellet, P.J.; Lippard, S.J. Science 1993, 261, 603.
41. Orphanides, G.; Wu, W.H.; Lane, W.S.; Hampsey, M.; Reinberg, D. Nature 1999, 400, 284.
42. Juo, Z.S.; Chiu, T.K.; Leiberman, P.M.; Baikalov, I.; Berk, A.J.; Dickerson, R.E. J. Mol. Biol. 1996, 261, 239.
43. Wei, M., Cohen, S.M.; Silverman, A.P.; Lippard, S.J. J. Biol. Chem. 2001, 276, 38774.
44. Yaneva, J.; Leuba, S.H.; Van Holde, K.; and Zlatanova, J. Proc. Natl. Acad. Sci. USA 1997, 94, 13448.
45. Kartalou, M.; Samson, L.D.; Essigman, J.M. Biochemistry 2000, 39, 8032.
46. Balckburn, E.H. Nature 1991, 350, 569.
47. Hananhan, D.; Weinberg, R.A. Cell 2000, 100, 57.
48. Blackburn, E.H. Cell 2001, 106, 661.
49. Harley, C.B.; Futcher A.B.; Greider, C.W. Nature 1990, 345, 458.
50. Holt, S.E.; Shay, J.W. J. Cell Physiol. 1999, 180, 10.
51. Shay, J.W.; Bacchetti, S. Eur. J. Cancer 1997, 33, 787.
52. Ishibasi, T.; Lippard, S.J. Proc. Natl. Acad. Sci. USA 1998, 95, 4219.
53. Daino, H.; Matsumara, I.; Takada, K.; Odajima, J.; Tanaka, H.; Ueda, S.; Shibayama, H.; Ikeda, H.; Hibi, M.; Machii, T.; Hirano, T.; Kanakura, Y. Blood 2000, 95, 2577.
54. Peleg-Shulman, T.; Gibson, D. J. Am. Chem. Soc. 2001, 123, 3171.
55. Wojcik, C.; Marczak, M.; Wilk, S. Anticancer Res. 2000, 20, 1717.
56. Fisher, D.E. Cell 1994, 78, 539.
57. Weller, M. Cell Tissue Res. 1998, 292, 435.
58. Wyllie, A.H. J. Pathol. 1987, 153, 313.
59. Barry, M.A.; Benhke, C.A.; Eastman, A. Biochem. Pharmacol. 1990, 40, 2353.
60. Pérez, J.M.; Montero, E.I.; González, A.M.; Alvarez-Valdés A.; Alonso, C.; Navarro-Ranninger, C. J. Inorg. Biochem. 1999, 77, 37.
61. Montero, E.I.; Pérez, J.M.; Schwartz, A.; Fuertes, M.A.; Malinge, J.M.; Alonso, C.; Leng, M.; Navarro-Ranninger, C. Chem. Bio. Chem. 2002, 3, 101.
62. Tanizawa, A.; Kubota, M.; Hashimoto, H., Shimizu, T.; Takimoto, T.; Kitoh, T.; Akiyama, Y.; Mikama, H. Exp. Cell Res. 1989, 185, 237.
63. Eastman, A. In Cisplatin: Chemistry and biochemistry of a leading anticancer drug. Lippert, B., Ed.; Wiley-VCH, Base, Switzerland. 1999. pp. 111-134.
64. Eliopoulos, A.G., Kerr D.J.; Herod, J.; Hodgkins, L.; Krajewski, S.; Reed, J.C.; Young, L.S. Oncogene 1995, 11, 1217.
65. Alnemri, E.S. J. Cell Biochem. 1997, 64, 33.
66. Kroemer, G.; Zamzami, N.; Susin, S.A. Immunol. Today 1997, 18, 44.
67. Green, D.R. Cell 1998, 94, 695.
68. Martin, D.S.; Bertino, J.R.; Koutcher, J.A. Cancer Res. 2000, 60, 6776.
69. Li, H.; Zhu, H.; Xu, C.J. Cell 1998, 94, 491.
70. Eguchi, Y.; Shimizu, S.; Tsujimoto, Y. Cancer Res. 1997, 57, 835.
71. Leist, M.; Single, B.; Castoldi, A.F.; Kühnle, S.; Nicotera P. J. Exp. Med. 1997, 185, 1481.
72. Green, D.R.; Reed, J.C. Science 1998, 281, 1309.
73. Herceg, Z.; Wang, Z.Q. Mol. Cell Biol. 1999, 19, 5124.
74. Hirsch, T., Marchetti, P.; Susin, S.; Dellaporta, B.; Zamzami, N.; Marzo, I.; Geuskens, M.; Kroemer, G. Oncogene 1997, 15, 1573.
75. Segal-Bendirdjian, E.; Jacquemin-Sablon, A. Exp. Cell Res. 1995, 218, 201.
76. Zhang, J.Y. Nature Rev. Drug. Discover. 2002, 1, 101.
77. González, V.M.; Fuertes, M.A.; Pérez-Alvarez, M.J.; Cervantes, G.; Moreno, V.; Alonso, C.; Pérez, J.M. Biochem. Pharmacol. 2000, 60, 371.
78. Raymond, E.; Faivre, S.; Chaney, S.; Woynarowsky, J.; Cvitkovic, E. Mol. Cancer Ther. 2002, 1, 227.