Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus

Neuropsychobiology

Volumn 63, Issue 3, 2011, Pages 160-168

  Barbon, Alessandro ^a   Orlandi, Cesare ^a   La Via, Luca ^a   Caracciolo, Luca ^a   Tardito, Daniela ^c   Musazzi, Laura ^c   Mallei, Alessandra ^c   Gennarelli, Massimo ^a,b   Racagni, Giorgio ^b,c   Popoli, Maurizio ^c   Barlati, Sergio ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

5 HTR2C; Antidepressants; Gene expression; Major depressive disorder; RNA editing

Indexed keywords

FLUOXETINE; MESSENGER RNA; REBOXETINE; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; FRONTAL CORTEX; GENE CONTROL; GENE EXPRESSION; HIPPOCAMPUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RNA EDITING; RNA SEQUENCE; UPREGULATION;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; DOWN-REGULATION; FLUOXETINE; FRONTAL LOBE; HIPPOCAMPUS; MALE; MORPHOLINES; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RNA EDITING; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; UP-REGULATION;

EID: 78651229425     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321593     Document Type: Article

References (52)

1. Belmaker RH, Agam G: Major depressive disorder. N Engl J Med 2008;358:55-68.
2. Pittenger C, Duman RS: Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 2008;33:88-109. (Pubitemid 350191319)
3. Millan MJ: Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 2006;110:135-370.
4. Higgins GA, Fletcher PJ: Serotonin and drug reward: focus on 5-HT2C receptors. Eur J Pharmacol 2003;480:151-162. (Pubitemid 37410367)
5. Barnes NM, Sharp T: A review of central 5-HT receptors and their function. Neuropharmacology 1999;38:1083-1152. (Pubitemid 29292403)
6. Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Faludi G, Sarosi A, Palkovits M: Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide. Neurochem Res 2006;31:167-176.
7. Castensson A, Emilsson L, Sundberg R, Jazin E: Decrease of serotonin receptor 2C in schizophrenia brains identified by high-resolution mRNA expression analysis. Biol Psychiatry 2003;54:1212-1221. (Pubitemid 37464867)
8. Iwamoto K, Kato T: RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci Lett 2003;346:169-172. (Pubitemid 36829288)
9. Serretti A, Artioli P, De Ronchi D: The 5-HT2C receptor as a target for mood disorders. Expert Opin Ther Targets 2004;8:15-23. (Pubitemid 38240021)
10. Di Giovanni G, Di Matteo V, Pierucci M, Benigno A, Esposito E: Central serotonin 2C receptor: from physiology to pathology. Curr Top Med Chem 2006;6:1909-1925. (Pubitemid 44524469)
11. Labrecque J, Fargin A, Bouvier M, Chidiac P, Dennis M: Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells. Mol Pharmacol 1995;48:150-159.
12. Newton RA, Elliott JM: Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y. J Neurochem 1997;69:1031-1038. (Pubitemid 27364823)
13. Esposito E: Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Curr Drug Targets 2006;7:177-185.
14. Gobert A, Rivet JM, Lejeune F, Newman- Tancredi A, Adhumeau-Auclair A, Nicolas JP, Cistarelli L, Melon C, Millan MJ: Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse 2000;36:205-221. (Pubitemid 30252995)
15. Millan MJ, Lejeune F, Gobert A: Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents. J Psychopharmacol 2000;14:114-138. (Pubitemid 30389486)
16. Sabbe B, Hulstijn W, Maes M, Pier M, Scharpe S, Zitman F: Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of metachlorophenylpiperazine in normal volunteers. Psychiatry Res 2001;105:151-163. (Pubitemid 34117643)
17. Clenet F, De Vos A, Bourin M: Involvement of 5-HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice. Eur Neuropsychopharmacol 2001;11:145-152. (Pubitemid 32366477)
18. Yamada J, Sugimoto Y: Effects of 5-HT(2) receptor antagonists on the anti-immobility effects of imipramine in the forced swimming test with mice. Eur J Pharmacol 2001;427:221-225.
19. Dremencov E, Newman ME, Kinor N, Blatman-Jan G, Schindler CJ, Overstreet DH, Yadid G: Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology 2005;48:34-42. (Pubitemid 40022913)
20. Werry TD, Loiacono R, Sexton PM, Christopoulos A: RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 2008;119:7-23.
21. Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB: Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 1997;387:303-308. (Pubitemid 27220768)
22. Wang Q, O'Brien PJ, Chen CX, Cho DS, Murray JM, Nishikura K: Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin2C receptors. J Neurochem 2000;74:1290-1300. (Pubitemid 30104328)
23. Dracheva S, Chin B, Haroutunian V: Altered serotonin 2C receptor RNA splicing in suicide: association with editing. Neuroreport 2008;19:379-382. (Pubitemid 351322981)
24. Dracheva S, Patel N, Woo DA, Marcus SM, Siever LJ, Haroutunian V: Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. Mol Psychiatry 2008;13:1001-1010.
25. Laakso A, Palvimaki EP, Kuoppamaki M, Syvalahti E, Hietala J: Chronic citalopram and fluoxetine treatments upregulate 5-HT2c receptors in the rat choroid plexus. Neuropsychopharmacology 1996;15:143-151. (Pubitemid 26255161)
26. Tohda M, Nomura M, Nomura Y: Molecular pathopharmacology of 5-HT2C receptors and the RNA editing in the brain. J Pharmacol Sci 2006;100:427-432. (Pubitemid 44609533)
27. Tohda M, Watanabe H: Imipramine-induced increase in 5-HT2C receptor mRNA level in the rat brain. Neurosci Res 1996;24:189-193. (Pubitemid 26048196)
28. De Foubert G, Carney SL, Robinson CS, Destexhe EJ, Tomlinson R, Hicks CA, Murray TK, Gaillard JP, Deville C, Xhenseval V, Thomas CE, O'Neill MJ, Zetterstrom TS: Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 2004;128:597-604. (Pubitemid 39277429)
29. Barbon A, Popoli M, La Via L, Moraschi S, Vallini I, Tardito D, Tiraboschi E, Musazzi L, Giambelli R, Gennarelli M, Racagni G, Barlati S: Regulation of editing and expression of glutamate alpha-amino-propionic-acid (AMPA)/kainate receptors by antidepressant drugs. Biol Psychiatry 2006;59:713-720.
30. Tardito D, Musazzi L, Tiraboschi E, Mallei A, Racagni G, Popoli M: Early induction of CREB activation and CREB-regulating signalling by antidepressants. Int J Neuropsychopharmacol 2009;12:1-15.
31. Dow AL, Russell DS, Duman RS: Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models. J Neurosci 2005;25:4908-4916. (Pubitemid 40712834)
32. Pfaffl MW, Horgan GW, Dempfle L: Relative expression software tool (REST) for groupwise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002;30:e36.
33. Barbon A, Vallini I, La Via L, Marchina E, Barlati S: Glutamate receptor RNA editing: a molecular analysis of GluR2, GluR5 and GluR6 in human brain tissues and in NT2 cells following in vitro neural differentiation. Brain Res Mol Brain Res 2003;117:168-178.
34. Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, Kato T: Altered RNA editing of serotonin 2C receptor in a rat model of depression. Neurosci Res 2005;53:69-76. (Pubitemid 41073729)
35. Liu S, Bubar MJ, Lanfranco MF, Hillman GR, Cunningham KA: Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: implications for understanding the neurobiology of addiction. Neuroscience 2007;146:1677-1688. (Pubitemid 46783202)
36. Blackburn JR, Pfaus JG, Phillips AG: Dopamine functions in appetitive and defensive behaviours. Prog Neurobiol 1992;39:247-279.
37. D'Aquila PS, Collu M, Gessa GL, Serra G: The role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol 2000;405:365-373.
38. Del Arco A, Mora F: Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex. Pharmacol Biochem Behav 2008;90:226-235.
39. Bhansali P, Dunning J, Singer SE, David L, Schmauss C: Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q. J Neurosci 2007;27:1467-1473.
40. Malberg JE, Eisch AJ, Nestler EJ, Duman RS: Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000;20:9104-9110. (Pubitemid 32042912)
41. Banasr M, Hery M, Printemps R, Daszuta A: Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology 2004;29:450-460. (Pubitemid 38365922)
42. Labasque M, Reiter E, Becamel C, Bockaert J, Marin P: Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G proteinindependent, arrestin-dependent receptor signaling. Mol Biol Cell 2008;19:4640-4650.
43. Szabo ST, Blier P: Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus. Neuropsychopharmacology 2001;25:845-857. (Pubitemid 34031891)
44. Ni YG, Miledi R: Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). Proc Natl Acad Sci USA 1997;94:2036-2040.
45. Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, Emeson RB, Sanders-Bush E: RNA editing of the human serotonin 5-HT2C receptor: alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology 2001;24:478-491. (Pubitemid 32244309)
46. Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C: Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 2002;34:349-356. (Pubitemid 34465494)
47. Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C: Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci 2002;22:10529-10532. (Pubitemid 36005126)
48. Yang W, Wang Q, Kanes SJ, Murray JM, Nishikura K: Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy. Brain Res Mol Brain Res 2004;124:70-78. (Pubitemid 38496275)
49. Englander MT, Dulawa SC, Bhansali P, Schmauss C: How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing. J Neurosci 2005;25:648-651.
50. Gardiner K, Du Y: A-to-I editing of the 5HT2C receptor and behaviour. Brief Funct Genomic Proteomic 2006;5:37-42. (Pubitemid 46402993)
51. Hackler EA, Airey DC, Shannon CC, Sodhi MS, Sanders-Bush E: 5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice. Neurosci Res 2006;55:96-104.
52. Du Y, Davisson MT, Kafadar K, Gardiner K: A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene 2006;382:39-46. (Pubitemid 44548253)