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Volumn 2, Issue 8, 2010, Pages 1734-1751

Core as a novel viral target for hepatitis C drugs

Author keywords

Core dimerization; HCV; Hepatitis C virus; Peptide inhibitors; Small molecule inhibitors; Virus assembly

Indexed keywords

ANTI HEPATITIS C VIRUS AGENT; ANTIVIRUS AGENT; CAPSID PROTEIN; GLYCOPROTEIN E1; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON; PEPTIDE DERIVATIVE; RIBAVIRIN; SL 173; SL 174; SL 175; SL 201; SL 209; UNCLASSIFIED DRUG;

EID: 78651227688     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v2081734     Document Type: Review
Times cited : (30)

References (82)
  • 1
    • 34250679750 scopus 로고    scopus 로고
    • Epidemiology of Hepatitis C infection
    • Alter, M.J. Epidemiology of Hepatitis C infection World J. Gastroenterol. 2007, 13, 2436-2441.
    • (2007) World J. Gastroenterol , vol.13 , pp. 2436-2441
    • Alter, M.J.1
  • 2
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • Lavanchy, D. The global burden of hepatitis C. Liver Int. 2009, 29, 74-81.
    • (2009) Liver Int , vol.29 , pp. 74-81
    • Lavanchy, D.1
  • 4
    • 0027522145 scopus 로고
    • Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
    • Simmonds, P.; Holmes, E.C.; Cha, T.A.; Chan, S.W.; McOmish, F.; Irvine, B.; Beall, E.; Yap, P.L.; Kolberg, J.; Urdea, M.S. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J. Gen. Virol. 1993, 74, 2391-2399.
    • (1993) J. Gen. Virol , vol.74 , pp. 2391-2399
    • Simmonds, P.1    Holmes, E.C.2    Cha, T.A.3    Chan, S.W.4    McOmish, F.5    Irvine, B.6    Beall, E.7    Yap, P.L.8    Kolberg, J.9    Urdea, M.S.10
  • 5
    • 34748873170 scopus 로고    scopus 로고
    • Flaviviridae: The viruses and their replication
    • 45th ed.; Knipe, D.M., Howley, P.M., Eds.; Lippincott-Raven Publishers, Philadelphia, PA, USA
    • Lindenbach, B.D.; Thiel, H.J.; Rice, C.M. Flaviviridae: The viruses and their replication. In Fields Virology, 45th ed.; Knipe, D.M., Howley, P.M., Eds.; Lippincott-Raven Publishers, Philadelphia, PA, USA, 2007; 1, pp. 1101-1152.
    • (2007) Fields Virology , vol.1 , pp. 1101-1152
    • Lindenbach, B.D.1    Thiel, H.J.2    Rice, C.M.3
  • 7
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo, Q.; Kuo, G.; Weiner, A.; Overby, L.; Bradley, D.; Houghton, M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989, 244, 359-365
    • (1989) Science , vol.244 , pp. 359-365
    • Choo, Q.1    Kuo, G.2    Weiner, A.3    Overby, L.4    Bradley, D.5    Houghton, M.6
  • 8
    • 34250681358 scopus 로고    scopus 로고
    • Hepatitis C virus proteins
    • Dubuisson, J. Hepatitis C virus proteins. World J. Gastroenterol. 2007, 13, 2406-2415.
    • (2007) World J. Gastroenterol , vol.13 , pp. 2406-2415
    • Dubuisson, J.1
  • 9
    • 23944476834 scopus 로고    scopus 로고
    • Unravelling hepatitis C virus replication from genome to function
    • Lindenbach, B.D.; Rice, C.M. Unravelling hepatitis C virus replication from genome to function. Nature 2005, 436, 933-938.
    • (2005) Nature , vol.436 , pp. 933-938
    • Lindenbach, B.D.1    Rice, C.M.2
  • 10
    • 34447333097 scopus 로고    scopus 로고
    • Hepatitis C virus genetic variability in patients undergoing antiviral therapy
    • Cristina, J.; Moreno-del Pilar, M.; Moratorio, G. Hepatitis C virus genetic variability in patients undergoing antiviral therapy. Virus Res. 2007, 127,185-194.
    • (2007) Virus Res , vol.127 , pp. 185-194
    • Cristina, J.1    del Pilar, M.M.2    Moratorio, G.3
  • 11
    • 34250643546 scopus 로고    scopus 로고
    • The interferon inducing pathways and the hepatitis C virus
    • Meurs, E.F.; Breiman, A. The interferon inducing pathways and the hepatitis C virus. World J. Gastroenterol. 2007, 13, 2446-2454.
    • (2007) World J. Gastroenterol , vol.13 , pp. 2446-2454
    • Meurs, E.F.1    Breiman, A.2
  • 12
    • 69549122650 scopus 로고    scopus 로고
    • An efficient and diastereoselective synthesis of PSI-6130: A clinically efficacious inhibitor of HCV NS5B polymerase
    • Wang, P.; Chun, B.K.; Rachakonda, S.; Du, J.; Khan, N.; Shi, J.; Stec, W.; Cleary, D.; Ross, B.S.; Sofia, M.J. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J. Org. Chem. 2009, 74, 6819-6824.
    • (2009) J. Org. Chem , vol.74 , pp. 6819-6824
    • Wang, P.1    Chun, B.K.2    Rachakonda, S.3    Du, J.4    Khan, N.5    Shi, J.6    Stec, W.7    Cleary, D.8    Ross, B.S.9    Sofia, M.J.10
  • 13
    • 79952168295 scopus 로고    scopus 로고
    • The IDX -08C-003 investigator group, Antiviral Activity, Pharmacokinetics and Safety of IDX184 in Combination with Pegylated Interferon (pegIFN) and Ribavirin (RBV) in Treatment-Naive HCV Genotype 1-infected Subjects
    • Lalezari, J.; Asmuth, D.; Vargas, H.; DubucPatrick, G.; Liu, W.; Pietropaolo, K.; Zhou, X.J.; Suulivan-Bolyal, J.; Mayers, D. The IDX -08C-003 investigator group, Antiviral Activity, Pharmacokinetics and Safety of IDX184 in Combination with Pegylated Interferon (pegIFN) and Ribavirin (RBV) in Treatment-Naive HCV Genotype 1-infected Subjects. EasL 2010, 4.15.10.
    • (2010) EasL , vol.4 , Issue.15 , pp. 10
    • Lalezari, J.1    Asmuth, D.2    Vargas, H.3    Dubucpatrick, G.4    Liu, W.5    Pietropaolo, K.6    Zhou, X.J.7    Suulivan-Bolyal, J.8    Mayers, D.9
  • 15
    • 72049091527 scopus 로고    scopus 로고
    • The efficacy and safety of telaprevir - a new protease inhibitor against hepatitis C virus
    • Gentile, I.; Carleo, M.A.; Borgia, F.; Castaldo, G.; Borgia, G. The efficacy and safety of telaprevir - a new protease inhibitor against hepatitis C virus. Expert Opin. Investig. Drugs 2010, 19, 151-159.
    • (2010) Expert Opin. Investig. Drugs , vol.19 , pp. 151-159
    • Gentile, I.1    Carleo, M.A.2    Borgia, F.3    Castaldo, G.4    Borgia, G.5
  • 16
    • 0032007554 scopus 로고    scopus 로고
    • Inhibiting Virus Capsid Assembly by Altering the Polymerization Pathway
    • Prevelige Jr., P.E. Inhibiting Virus Capsid Assembly by Altering the Polymerization Pathway. Trends Biotechnol. 1998, 16, 61-65.
    • (1998) Trends Biotechnol , vol.16 , pp. 61-65
    • Prevelige, P.E.1
  • 17
    • 33750704335 scopus 로고    scopus 로고
    • Global Structural Changes in Hepatitis B Virus Capsids Induced by the Assembly Effector HAP1
    • Bourne, C.R.; Finn, M.G.; Zlotnick, A. Global Structural Changes in Hepatitis B Virus Capsids Induced by the Assembly Effector HAP1. J. Virol. 2006, 80, 11055-11061.
    • (2006) J. Virol , vol.80 , pp. 11055-11061
    • Bourne, C.R.1    Finn, M.G.2    Zlotnick, A.3
  • 18
    • 0030970693 scopus 로고    scopus 로고
    • Core structure of gp41 from the HIV envelope glycoprotein
    • Chan, D.C.; Fass, D.; Berger, J.M.; Kim, P.S. Core structure of gp41 from the HIV envelope glycoprotein. Cell 1997, 89, 263-273.
    • (1997) Cell , vol.89 , pp. 263-273
    • Chan, D.C.1    Fass, D.2    Berger, J.M.3    Kim, P.S.4
  • 21
    • 33750947650 scopus 로고    scopus 로고
    • Resistance of hepatitis C virus to NS3-4A protease inhibitors: Mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations
    • Courcambeck, J.; Bouzidi, M.; Perbost, R.; Jouirou, B.; Amrani, N.; Cacoub, P.; Pepe, G.; Sabatier, J.M.; Halfon, P. Resistance of hepatitis C virus to NS3-4A protease inhibitors: mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations. Antivir. Ther. 2006, 11, 847-855.
    • (2006) Antivir. Ther , vol.11 , pp. 847-855
    • Courcambeck, J.1    Bouzidi, M.2    Perbost, R.3    Jouirou, B.4    Amrani, N.5    Cacoub, P.6    Pepe, G.7    Sabatier, J.M.8    Halfon, P.9
  • 22
    • 35748953422 scopus 로고    scopus 로고
    • Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
    • De Francesco, R.; Carfi, A. Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Adv. Drug Delivery. Rev. 2007, 59, 1242-1262.
    • (2007) Adv. Drug Delivery. Rev , vol.59 , pp. 1242-1262
    • de Francesco, R.1    Carfi, A.2
  • 23
    • 67649221455 scopus 로고    scopus 로고
    • Peptide inhibitors of Hepatitis C Virus core oligomerization and virus production
    • Kota, S.; Coito, C.; Mousseau, G.; Lavergne, J-P; Strosberg, A.D. Peptide inhibitors of Hepatitis C Virus core oligomerization and virus production. J. Gen. Virol. 2009, 90,1319-1328.
    • (2009) J. Gen. Virol , vol.90 , pp. 1319-1328
    • Kota, S.1    Coito, C.2    Mousseau, G.3    Lavergne, J.-P.4    Strosberg, A.D.5
  • 24
    • 0029897323 scopus 로고    scopus 로고
    • Interaction between hepatitis C virus core protein and E1 envelope protein
    • Lo, S.Y.; Selby, M.J.; Ou, J.H. Interaction between hepatitis C virus core protein and E1 envelope protein. J. Virol. 1996, 70, 5177-5182.
    • (1996) J. Virol , vol.70 , pp. 5177-5182
    • Lo, S.Y.1    Selby, M.J.2    Ou, J.H.3
  • 25
    • 34648827871 scopus 로고    scopus 로고
    • Alanine Scanning of the Hepatitis C Virus Core Protein Reveals Numerous Residues Essential for Infectious Virus Production
    • Murray, C.L.; Jones, C.T.; Tassello, J.; Rice, C.M. Alanine Scanning of the Hepatitis C Virus Core Protein Reveals Numerous Residues Essential for Infectious Virus Production. J. Virol. 2007, 81, 10220-10231.
    • (2007) J. Virol , vol.81 , pp. 10220-10231
    • Murray, C.L.1    Jones, C.T.2    Tassello, J.3    Rice, C.M.4
  • 26
    • 47749092840 scopus 로고    scopus 로고
    • NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly
    • Ma, Y.; Yates, J.; Liang, Y.; Lemon, S.M.; Yi, M. NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly. J. Virol. 2008, 82, 7624-7639.
    • (2008) J. Virol , vol.82 , pp. 7624-7639
    • Ma, Y.1    Yates, J.2    Liang, Y.3    Lemon, S.M.4    Yi, M.5
  • 27
    • 67349268146 scopus 로고    scopus 로고
    • Lipid droplets and hepatitis C infection
    • McLauchlan, J. Lipid droplets and hepatitis C infection. Biochim. Biophys. Acta 2009, 1791, 552-559.
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 552-559
    • McLauchlan, J.1
  • 30
    • 0035950925 scopus 로고    scopus 로고
    • The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage
    • Goh, P.Y.; Tan, Y.J.; Lim, S.P.; Lim, S.G.; Tan, Y.H.; Hong, W.J. The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage. Virology 2001, 290, 224-236.
    • (2001) Virology , vol.290 , pp. 224-236
    • Goh, P.Y.1    Tan, Y.J.2    Lim, S.P.3    Lim, S.G.4    Tan, Y.H.5    Hong, W.J.6
  • 31
    • 0037404536 scopus 로고    scopus 로고
    • Protein-protein interactions between hepatitis C virus nonstructural proteins
    • Dimitrova, M.; Imbert, I.; Kieny, M.P.; Schuster, C. Protein-protein interactions between hepatitis C virus nonstructural proteins. J. Virol. 2003, 77, 5401-5414.
    • (2003) J. Virol , vol.77 , pp. 5401-5414
    • Dimitrova, M.1    Imbert, I.2    Kieny, M.P.3    Schuster, C.4
  • 32
    • 49149113893 scopus 로고    scopus 로고
    • Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
    • Masaki, T.; Suzuki, R.; Murakami, K.; Aizaki, H.; Ishii, K.; Murayama, A.; Date, T.; Matsuura, Y.; Miyamura, T.; Wakita, T.; Suzuki, T. Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles J. Virol. 2008, 82, 7964-7976.
    • (2008) J. Virol , vol.82 , pp. 7964-7976
    • Masaki, T.1    Suzuki, R.2    Murakami, K.3    Aizaki, H.4    Ishii, K.5    Murayama, A.6    Date, T.7    Matsuura, Y.8    Miyamura, T.9    Wakita, T.10    Suzuki, T.11
  • 34
    • 56949094892 scopus 로고    scopus 로고
    • Structure and dynamics of the N-terminal half of hepatitis C virus core protein: An intrinsically unstructured protein
    • Duvignaud, J.B.; Savard, C.; Fromentin, R.; Majeau, N.; Leclerc, D.; Gagné, S.M. Structure and dynamics of the N-terminal half of hepatitis C virus core protein: An intrinsically unstructured protein. Biochem. Biophys. Res. Commun. 2008, 378, 27-31.
    • (2008) Biochem. Biophys. Res. Commun , vol.378 , pp. 27-31
    • Duvignaud, J.B.1    Savard, C.2    Fromentin, R.3    Majeau, N.4    Leclerc, D.5    Gagné, S.M.6
  • 36
    • 37549005607 scopus 로고    scopus 로고
    • The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly
    • Shavinskay, A.; Boulant, S.; Penin, F.; McLauchlan, J.; Bartenschlager, R. The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J.Biol.Chem. 2007, 282, 37158-37169.
    • (2007) J.Biol.Chem , vol.282 , pp. 37158-37169
    • Shavinskay, A.1    Boulant, S.2    Penin, F.3    McLauchlan, J.4    Bartenschlager, R.5
  • 38
    • 0028233530 scopus 로고
    • Biosynthesis and biochemical properties of the hepatitis C virus core protein
    • Santolini, E.; Migliaccio, G.; LaMonica, N. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol. 1994, 68, 3631-3641.
    • (1994) J. Virol , vol.68 , pp. 3631-3641
    • Santolini, E.1    Migliaccio, G.2    Lamonica, N.3
  • 39
    • 0030273064 scopus 로고    scopus 로고
    • Hepatitis C Virus Core Protein: Carboxy-Terminal Boundaries of Two Processed Species Suggest Cleavage by a Signal Peptide Peptidase
    • Hüssy, P.; Langen, H.; Mous, J.; Jacobsen, H. Hepatitis C Virus Core Protein: Carboxy-Terminal Boundaries of Two Processed Species Suggest Cleavage by a Signal Peptide Peptidase Virology 1996, 224, 93-104.
    • (1996) Virology , vol.224 , pp. 93-104
    • Hüssy, P.1    Langen, H.2    Mous, J.3    Jacobsen, H.4
  • 40
    • 0036683052 scopus 로고    scopus 로고
    • Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
    • McLauchlan, J.; Lemberg, M.K.; Hope, G.; Martoglio, B. Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J. 2002, 21, 3980-3988.
    • (2002) EMBO J , vol.21 , pp. 3980-3988
    • McLauchlan, J.1    Lemberg, M.K.2    Hope, G.3    Martoglio, B.4
  • 41
    • 70349284497 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus core protein multimerization and membrane envelopment: Revelation of a cascade of core-membrane interactions
    • Ai, L.; Lee, Y.W.; Chen, S.S. Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions. J. Virol. 2009, 83, 9923-9939.
    • (2009) J. Virol , vol.83 , pp. 9923-9939
    • Ai, L.1    Lee, Y.W.2    Chen, S.S.3
  • 42
    • 34547734952 scopus 로고    scopus 로고
    • Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    • Jones, C.T.; Murray, C.; Eastman, D.K.; Tassello, J.; Rice, C.M. Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J. Virol. 2007, 81, 8374-8383.
    • (2007) J. Virol , vol.81 , pp. 8374-8383
    • Jones, C.T.1    Murray, C.2    Eastman, D.K.3    Tassello, J.4    Rice, C.M.5
  • 43
    • 33846111662 scopus 로고    scopus 로고
    • Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
    • Yi, M.; Ma, Y.; Yates, J.; Lemon, S.M. Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus. J. Virol. 2007, 81, 629-638.
    • (2007) J. Virol , vol.81 , pp. 629-638
    • Yi, M.1    Ma, Y.2    Yates, J.3    Lemon, S.M.4
  • 44
    • 77956397284 scopus 로고    scopus 로고
    • Role of lipid metabolism in hepatitis C virus assembly and entry
    • Popescu, C.I.; Dubuisson, J. Role of lipid metabolism in hepatitis C virus assembly and entry. Biol. Cell 2009, 102, 63-74.
    • (2009) Biol. Cell , vol.102 , pp. 63-74
    • Popescu, C.I.1    Dubuisson, J.2
  • 46
    • 75449084143 scopus 로고    scopus 로고
    • Genetic analysis of the carboxy -terminal region of the Hepatitis C virus core protein
    • Kopp, M.; Murray, C.L.; Jones, C.T.; Rice, C.M. Genetic analysis of the carboxy -terminal region of the Hepatitis C virus core protein. J. Virol. 2010, 84, 1666-1673.
    • (2010) J. Virol , vol.84 , pp. 1666-1673
    • Kopp, M.1    Murray, C.L.2    Jones, C.T.3    Rice, C.M.4
  • 47
    • 70350142577 scopus 로고    scopus 로고
    • Hepatitis C virus: Viral proteins on the move
    • McLauchlan, J. Hepatitis C virus: viral proteins on the move. Biochem. Soc. Trans. 2009, 37, 986-990.
    • (2009) Biochem. Soc. Trans , vol.37 , pp. 986-990
    • McLauchlan, J.1
  • 49
    • 77956629698 scopus 로고    scopus 로고
    • Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein
    • DOI:0.1007/s00018-010-0373-z
    • Depla, M.; Uzbekov, R.; Hourioux, C.; Blanchard, E.; LeGouge, A.; Gillet, L.; Roingeard, P. Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein. Cell Mol. Life Sci. 2010, DOI:0.1007/s00018-010-0373-z.
    • (2010) Cell Mol. Life Sci
    • Depla, M.1    Uzbekov, R.2    Hourioux, C.3    Blanchard, E.4    Legouge, A.5    Gillet, L.6    Roingeard, P.7
  • 50
    • 33750360303 scopus 로고    scopus 로고
    • Structural requirements for assembly and homotypic interactions of the hepatitis C virus core protein
    • Kim, M.; Ha, Y.; Park, H.J. Structural requirements for assembly and homotypic interactions of the hepatitis C virus core protein. Virus Res. 2006, 122,137-143.
    • (2006) Virus Res , vol.122 , pp. 137-143
    • Kim, M.1    Ha, Y.2    Park, H.J.3
  • 51
    • 34547592075 scopus 로고    scopus 로고
    • Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus
    • Boulant, S.; Targett-Adams, P.; McLauchlan, J. Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. J. Gen. Virol. 2007, 88, 2204-2213.
    • (2007) J. Gen. Virol , vol.88 , pp. 2204-2213
    • Boulant, S.1    Targett-Adams, P.2    McLauchlan, J.3
  • 52
    • 3042576370 scopus 로고    scopus 로고
    • The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro
    • Cristofari, G.; Ivanyi-Nagy, R.; Gabus, C.; Boulant, S.; Lavergne, J.P.; Penin, F.; Darlix, J.L. The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro. Nucleic Acids Res. 2004, 32, 2623-2631.
    • (2004) Nucleic Acids Res , vol.32 , pp. 2623-2631
    • Cristofari, G.1    Ivanyi-Nagy, R.2    Gabus, C.3    Boulant, S.4    Lavergne, J.P.5    Penin, F.6    Darlix, J.L.7
  • 55
    • 23844530172 scopus 로고    scopus 로고
    • Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features
    • Boulant, S.; Vanabelle, C.; Ebel, C.; Penin, F.; Lavergne, J.P. Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features. J. Virol. 2005, 79, 11353-11365.
    • (2005) J. Virol , vol.79 , pp. 11353-11365
    • Boulant, S.1    Vanabelle, C.2    Ebel, C.3    Penin, F.4    Lavergne, J.P.5
  • 56
    • 0036809216 scopus 로고    scopus 로고
    • Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis
    • Lemberg, M.K.; Martoglio, B. Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis. Mol. Cell. 2002, 10, 735-744.
    • (2002) Mol. Cell , vol.10 , pp. 735-744
    • Lemberg, M.K.1    Martoglio, B.2
  • 57
    • 50149086906 scopus 로고    scopus 로고
    • Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
    • Okamoto, K.; Mori, Y.; Komoda, Y.; Okamoto, T.; Okochi, M.; Takeda, M.; Suzuki, T.; Morishi, K.; Matsuura, Y. Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation. J. Virol. 2008, 82, 8349-8361.
    • (2008) J. Virol , vol.82 , pp. 8349-8361
    • Okamoto, K.1    Mori, Y.2    Komoda, Y.3    Okamoto, T.4    Okochi, M.5    Takeda, M.6    Suzuki, T.7    Morishi, K.8    Matsuura, Y.9
  • 59
    • 0035130118 scopus 로고    scopus 로고
    • Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein
    • Kunkel, M.; Lorinczi, M.; Rijnbrand, R.; Lemon, S.M.; Watowich, S.J. Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein. J. Virol. 2001, 75, 2119-2129.
    • (2001) J. Virol , vol.75 , pp. 2119-2129
    • Kunkel, M.1    Lorinczi, M.2    Rijnbrand, R.3    Lemon, S.M.4    Watowich, S.J.5
  • 60
    • 34547592075 scopus 로고    scopus 로고
    • Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus
    • Boulant, S.; Targett-Adams, P.; McLauchlan, J. Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. J. Gen. Virol. 2007, 88, 2204-2213.
    • (2007) J. Gen. Virol , vol.88 , pp. 2204-2213
    • Boulant, S.1    Targett-Adams, P.2    McLauchlan, J.3
  • 64
    • 4143071422 scopus 로고    scopus 로고
    • Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly
    • Klein, K.C.; Polyak, S.J.; Lingappa, J.R. Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J. Virol. 2004, 78, 9257-9269.
    • (2004) J. Virol , vol.78 , pp. 9257-9269
    • Klein, K.C.1    Polyak, S.J.2    Lingappa, J.R.3
  • 65
    • 1842854065 scopus 로고    scopus 로고
    • The Nterminal half of the core protein of hepatitis C virus is sufficient for nucleocapsid formation
    • Majeau, N.; Gagne, V.; Boivin, A.; Bolduc, M.; Majeau, J.A.; Ouellet, D.; Leclerc, D. The Nterminal half of the core protein of hepatitis C virus is sufficient for nucleocapsid formation. J. Gen. Virol. 2004, 85, 971-981.
    • (2004) J. Gen. Virol , vol.85 , pp. 971-981
    • Majeau, N.1    Gagne, V.2    Boivin, A.3    Bolduc, M.4    Majeau, J.A.5    Ouellet, D.6    Leclerc, D.7
  • 66
    • 79952170752 scopus 로고    scopus 로고
    • Palmitoylation of hepatitis C virus core protein is important for virion production
    • Majeau, N.; Fromentin, R.; Savard, C.; Duval, M.; Tremblay, M.J.; Leclerc, D. Palmitoylation of hepatitis C virus core protein is important for virion production. J. Biol. Chem. 2009, 85, 971-981.
    • (2009) J. Biol. Chem , vol.85 , pp. 971-981
    • Majeau, N.1    Fromentin, R.2    Savard, C.3    Duval, M.4    Tremblay, M.J.5    Leclerc, D.6
  • 67
    • 0031712813 scopus 로고    scopus 로고
    • The Core Protein of Hepatitis C Virus Induces Hepatocellular Carcinoma in Transgenic Mice
    • Moriya, K.; Fujie, H. The Core Protein of Hepatitis C Virus Induces Hepatocellular Carcinoma in Transgenic Mice. Nat. Med. 1998, 4, 1065-1069.
    • (1998) Nat. Med , vol.4 , pp. 1065-1069
    • Moriya, K.1    Fujie, H.2
  • 71
    • 2142829476 scopus 로고    scopus 로고
    • Development of a highthroughput screening assay for inhibitors of aggrecan cleavage using luminescent oxygen channeling (AlphaScreen)
    • Peppard, J.; Glickman, F.; He, Y.; Hu, S.I.; Doughty, J.; Goldberg, R. Development of a highthroughput screening assay for inhibitors of aggrecan cleavage using luminescent oxygen channeling (AlphaScreen). J. Biomol. Screen. 2003, 8, 149-156.
    • (2003) J. Biomol. Screen , vol.8 , pp. 149-156
    • Peppard, J.1    Glickman, F.2    He, Y.3    Hu, S.I.4    Doughty, J.5    Goldberg, R.6
  • 72
    • 37249004920 scopus 로고    scopus 로고
    • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
    • Wells, J.A.; McClendon, C.L. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007, 450, 1001-1009.
    • (2007) Nature , vol.450 , pp. 1001-1009
    • Wells, J.A.1    McClendon, C.L.2
  • 75
    • 0001122904 scopus 로고
    • The Aspidosperma Alkaloids
    • Manske, R.H.F., Rodrigo, R.G.A., Eds.; Academic Press, NewYork, NY, USA
    • Cordell, G.A. The Aspidosperma Alkaloids. In The Alkaloids, Manske, R.H.F., Rodrigo, R.G.A., Eds.; Academic Press, NewYork, NY, USA, 1978, 17, pp. 199-384.
    • (1978) The Alkaloids , vol.17 , pp. 199-384
    • Cordell, G.A.1
  • 76
    • 0347225187 scopus 로고    scopus 로고
    • Alkaloids of the Aspidospermine Group
    • Cordell, G.A, Ed.; Academic Press: New York, NY, USA
    • Saxton, J.E. Alkaloids of the Aspidospermine Group. In The Alkaloids. Cordell, G.A, Ed.; Academic Press: New York, NY, USA, 1998, 51, pp. 2-198.
    • (1998) The Alkaloids , vol.51 , pp. 2-198
    • Saxton, J.E.1
  • 77
    • 0034712239 scopus 로고    scopus 로고
    • Intramolecular Inverse Electron Demand Diels-Alder Reactions of Tryptamine with Tethered Heteroaromatic Azadienes
    • Benson, S.C.; Lee, L.; Yang, L.; Snyder, J.K. Intramolecular Inverse Electron Demand Diels-Alder Reactions of Tryptamine with Tethered Heteroaromatic Azadienes. Tetrahedron 2000, 56, 1165-1180.
    • (2000) Tetrahedron , vol.56 , pp. 1165-1180
    • Benson, S.C.1    Lee, L.2    Yang, L.3    Snyder, J.K.4


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