Peptide inhibitors of hepatitis C virus core oligomerization and virus production

Journal of General Virology

Volumn 90, Issue 6, 2009, Pages 1319-1328

  Kota, S ^a   Coito, C ^a   Mousseau, G ^a   Lavergne, J P ^b   Strosberg, A D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

SL173 PROTEIN; SL174 PROTEIN; SL175 PROTEIN; SL571 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; ANTIVIRUS AGENT; CORE PROTEIN; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; PEPTIDE;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; VIRUS CELL INTERACTION; VIRUS CORE; VIRUS INHIBITION; VIRUS REPLICATION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN IMMUNODEFICIENCY VIRUS; KINETICS; LIVER CELL; METABOLISM; PROTEIN BINDING; VIROLOGY;

HEPATITIS C VIRUS;

ANTIVIRAL AGENTS; CELL LINE; DIMERIZATION; HEPACIVIRUS; HEPATOCYTES; HIV; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; PEPTIDES; PROTEIN BINDING; VIRAL CORE PROTEINS; VIRUS REPLICATION;

EID: 67649221455     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.008565-0     Document Type: Article

References (40)

1. Boulant, S., Vanbelle, C., Ebel, C., Penin, F. & Lavergne, J. P. (2005). Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features. J Virol 79, 11353-11365.
2. Chen, W., Zhang, Z., Chen, J., Zhang, J., Zhang, J., Wu, Y., Huang, Y., Cai, X. & Huang, A. (2008). HCV core protein interacts with Dicer to antagonize RNA silencing. Virus Res 133, 250-258.
3. Cheng, G., Montero, A., Gastaminza, P., Whitten-Bauer, C., Wieland, S. F., Isogawa, M., Fredericksen, B., Selvarajah, S., Gallay, P. A. & other authors (2008). A virocidal amphipathic α-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A 105, 3088-3093.
4. Choo, Q. L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W. & Houghton, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359.
5. Dandliker, W. B., Kelly, R. J., Dandliker, J., Farquahar, J. & Levin, J. (1973). Fluorescence polarization immunoassay. Theory and experimental method. Immunochemistry 10, 219-227.
6. De Francesco, R. & Carfí, A. (2007). Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Adv Drug Deliv Rev 59, 1242-1262.
7. Flajolet, M., Rotondo, G., Daviet, L., Bergametti, F., Inchauspé, G., Tiollais, P., Transy, C. & Legrain, P. (2000). A genomic approach of the hepatitis C virus generates a protein interaction map. Gene 242, 369-379.
8. Fromentin, R., Majeau, N., Laliberté Gagné, M. E., Boivin, A., Duvignaud, J. B. & Leclerc, D. (2007). A method for in vitro assembly of hepatitis C virus core protein and for screening of inhibitors. Anal Biochem 366, 37-45.
9. Giannini, C. & Brechot, C. (2003). Hepatitis C virus biology. Cell Death Differ 10, S27-S38.
10. Grakoui, A., Wychowski, C., Lin, C., Feinstone, S. M. & Rice, C. M. (1993). Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 67, 1385-1395.
11. Hijikata, M., Kato, N., Ootsuyama, Y., Nakagawa, M. & Shimotohno, K. (1991). Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci U S A 88, 5547-5551.
12. Jones, C. T., Murray, C. L., Eastman, D. K., Tassello, J. & Rice, C. M. (2007). Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 81, 8374-8383.
13. Klein, K. C., Polyak, S. J. & Lingappa, J. R. (2004). Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J Virol 78, 9257-9269.
14. Klein, K. C., Dellos, S. R. & Lingappa, J. R. (2005). Identification of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system. J Virol 79, 6814-6826.
15. Kunkel, M., Lorinczi, M., Rijnbrand, R., Lemon, S. M. & Watowich, S. J. (2001). Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein. J Virol 75, 2119-2129.
16. Lindenbach, B. D. & Rice, C. M. (2005). Unravelling hepatitis C virus replication from genome to function. Nature 436, 933-938.
17. Lindenbach, B. D., Evans, M. J., Syder, A. J., Wolk, B., Tellinghuisen, T. L., Liu, C. C., Maruyama, T., Hynes, R. O., Burton, D. R. & other authors (2005). Complete replication of hepatitis C virus in cell culture. Science 309, 623-626.
18. Liu, Q., Tackney, C., Bhat, R. A., Prince, A. M. & Zhang, P. (1997). Regulated processing of hepatitis C virus core protein is linked to subcellular localization. J Virol 71, 657-662.
19. Lo, S. Y., Selby, M. J. & Ou, J. H. (1996). Interaction between hepatitis C virus core protein and E1 envelope protein. J Virol 70, 5177-5182.
20. Ma, H. C., Ke, C. H., Hsieh, T. Y. & Lo, S. Y. (2002). The first hydrophobic domain of the hepatitis C virus E1 protein is important for interaction with the capsid protein. J Gen Virol 83, 3085-3092.
21. Maillard, P., Lavergne, J. P., Siberil, S., Faure, G., Roohvand, F., Petres, S., Teillaud, J. L. & Budkowska, A. (2004). Fcγ receptor-like activity of hepatitis C virus core protein. J Biol Chem 279, 2430-2437.
22. Majeau, N., Gagne, V., Boivin, A., Bolduc, M., Majeau, J. A., Ouellet, D. & Leclerc, D. (2004). The N-terminal half of the core protein of hepatitis C virus is sufficient for nucleocapsid formation. J Gen Virol 85, 971-981.
23. McLauchlan, J. (2000). Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat 7, 2-14.
24. McLauchlan, J., Lamberg, M. K., Hope, G. & Martoglio, B. (2002). Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. EMBO J 21, 3980-3988.
25. Miyanari, Y., Atsuzawa, K., Usuda, N., Watashi, K., Hishiki, T., Zayas, M., Bartenschlager, R., Wakita, T., Hijikata, M. & Shimotohno, K. (2007). The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 9, 1089-1097.
26. Murray, C. L., Jones, C. T., Tassello, J. & Rice, C. M. (2007). Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for infectious virus production. J Virol 81, 10220-10231.
27. Nolandt, O., Kern, V., Muller, H., Pfaff, E., Theilmann, L., Welker, R. & Krausslich, H. G. (1997). Analysis of hepatitis C virus core protein interaction domains. J Gen Virol 78, 1331-1340.
28. Okamoto, K., Mori, Y., Komoda, Y., Okamoto, T., Okochi, M., Takeda, M., Suzuki, T., Moriishi, K. & Matsuura, Y. (2008). Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation. J Virol 82, 8349-8361.
29. Paeshuyse, J., Kaul, A., De Clercq, E., Rosenwirth, B., Dumont, J. M., Scalfaro, P., Bartenschlager, R. & Neyts, J. (2006). The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology 43, 761-770.
30. Penin, F., Dubuisson, J., Rey, F. A., Moradpour, D. & Pawlotsky, J. M. (2004). Structural biology of hepatitis C virus. Hepatology 39, 5-19.
31. Peppard, J., Glickman, F., He, Y., Hu, S. I., Doughty, J. & Goldberg, R. (2003). Development of a high-throughput screening assay for inhibitors of aggrecan cleavage using luminescent oxygen channeling (AlphaScreen). J Biomol Screen 8, 149-156.
32. Roingeard, P. & Hourioux, C. (2008). Hepatitis C virus core protein, lipid droplets and steatosis. J Viral Hepat 15, 157-164.
33. Shavinskaya, A., Boulant, S., Penin, F., McLauchlan, J. & Bartenschlager, R. (2007). The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J Biol Chem 282, 37158-37169.
34. Suzuki, R., Sakamoto, S., Tsutsumi, T., Rikimaru, A., Tanaka, K., Shimoike, T., Moriishi, K., Iwasaki, T., Mizumoto, K. & other authors (2005). Molecular determinants for subcellular localization of hepatitis C virus core protein. J Virol 79, 1271-1281.
35. Tellinghuisen, T. L., Foss, K. L. & Treadaway, J. (2008). Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog 4, e1000032.
36. Thibeault, D., Bousquet, C., Gingras, R., Lagace, L., Maurice, R., White, P. W. & Lamarre, D. (2004). Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061. J Virol 78, 7352-7359.
37. Wakita, T., Pietschmann, T., Kato, T., Date, T., Miyamoto, M., Zhao, Z., Murthy, K., Habermann, A., Krausslich, H. G. & other authors (2005). Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11, 791-796.
38. Wells, J. A. & McClendon, C. L. (2007). Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450, 1001-1009.
39. Yan, X.-B., Battaglia, S., Boucreux, D., Chen, Z., Brechot, C. & Pavio, N. (2007). Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA- activated protein kinase PKR. Virus Res 125, 79-87.
40. Zhong, J., Gastaminza, P., Cheng, G., Kapadia, S., Kato, T., Burton, D. R., Wieland, S. F., Uprichard, S. L., Wakita, T. & Chisari, F. V. (2005). Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A 102, 9294-9299.