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Volumn 27, Issue 1, 2011, Pages 47-53

Biphasic effects of chronic ethanol exposure on insulin-stimulated glucose uptake in primary cultured rat skeletal muscle cells: Role of the Akt pathway and GLUT4

Author keywords

Akt; Ethanol; GLUT4; Insulin resistance; PI3K

Indexed keywords

ALCOHOL; DEOXYGLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 78651100602     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1152     Document Type: Article
Times cited : (9)

References (39)
  • 1
    • 70449394764 scopus 로고    scopus 로고
    • Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis
    • Baliunas DO, Taylor BJ, Irving H, et al. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 2009; 32(11): 2123-2132.
    • (2009) Diabetes Care , vol.32 , Issue.11 , pp. 2123-2132
    • Baliunas, D.O.1    Taylor, B.J.2    Irving, H.3
  • 2
    • 0141446279 scopus 로고    scopus 로고
    • Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish twin cohort study
    • Carlsson S, Hammar N, Grill V, Kaprio J. Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish twin cohort study. Diabetes Care 2003; 26: 2785-2790.
    • (2003) Diabetes Care , vol.26 , pp. 2785-2790
    • Carlsson, S.1    Hammar, N.2    Grill, V.3    Kaprio, J.4
  • 3
    • 67651093742 scopus 로고    scopus 로고
    • Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms
    • Djoussé L, Lee IM, Buring JE, Gaziano JM. Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms. Circulation 2009; 120(3): 237-244.
    • (2009) Circulation , vol.120 , Issue.3 , pp. 237-244
    • Djoussé, L.1    Lee, I.M.2    Buring, J.E.3    Gaziano, J.M.4
  • 4
    • 0036185148 scopus 로고    scopus 로고
    • Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study)
    • AIR study group.
    • Goude D, Fagerberg B, Hulthe J; AIR study group. Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study). Clin Sci (Lond) 2002; 102(3): 345-352.
    • (2002) Clin Sci (Lond) , vol.102 , Issue.3 , pp. 345-352
    • Goude, D.1    Fagerberg, B.2    Hulthe, J.3
  • 5
    • 0029851948 scopus 로고    scopus 로고
    • Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study)
    • Kiechl S, Willeit J, Poewe W, et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). BMJ 1996; 313(7064): 1040-1044.
    • (1996) BMJ , vol.313 , Issue.7064 , pp. 1040-1044
    • Kiechl, S.1    Willeit, J.2    Poewe, W.3
  • 6
    • 33845244172 scopus 로고    scopus 로고
    • Pathophysiology of insulin resistance
    • Sesti G. Pathophysiology of insulin resistance. Best Pract Res Clin Endocrinol Metab 2006; 20(4): 665-679.
    • (2006) Best Pract Res Clin Endocrinol Metab , vol.20 , Issue.4 , pp. 665-679
    • Sesti, G.1
  • 7
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296(5573): 1655-1657.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 8
    • 29244462334 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose transport
    • Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regulation of glucose transport. Mol Med 2004; 10(7-12): 65-71.
    • (2004) Mol Med , vol.10 , Issue.7-12 , pp. 65-71
    • Chang, L.1    Chiang, S.H.2    Saltiel, A.R.3
  • 9
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006; 7(2): 85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 10
    • 0344211825 scopus 로고    scopus 로고
    • Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation
    • Onishi Y, Honda M, Ogihara T, et al. Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation. Biochem Biophys Res Commun 2003; 303(3): 788-794.
    • (2003) Biochem Biophys Res Commun , vol.303 , Issue.3 , pp. 788-794
    • Onishi, Y.1    Honda, M.2    Ogihara, T.3
  • 11
    • 23044432133 scopus 로고    scopus 로고
    • In vivo insulin signaling through PI3-kinase is impaired in skeletal muscle of adult rat offspring exposed to ethanol in utero
    • Chen L, Yao XH, Nyomba BL. In vivo insulin signaling through PI3-kinase is impaired in skeletal muscle of adult rat offspring exposed to ethanol in utero. J Appl Physiol 2005; 99(2): 528-534.
    • (2005) J Appl Physiol , vol.99 , Issue.2 , pp. 528-534
    • Chen, L.1    Yao, X.H.2    Nyomba, B.L.3
  • 12
    • 1842423809 scopus 로고    scopus 로고
    • Ethanol impairs insulin's actions through phosphatidylinositol 3-kinase
    • Yi SJ, Jhun BH. Ethanol impairs insulin's actions through phosphatidylinositol 3-kinase. J Med Food 2004; 7(1): 24-30.
    • (2004) J Med Food , vol.7 , Issue.1 , pp. 24-30
    • Yi, S.J.1    Jhun, B.H.2
  • 13
    • 0023272730 scopus 로고
    • Cultured myotubes from skeletal muscle of adult rats. Characterization and action of Anemonia sulcata toxin II
    • Tesseraux I, Gülden M, Wassermann O. Cultured myotubes from skeletal muscle of adult rats. Characterization and action of Anemonia sulcata toxin II. Naunyn Schmiedebergs Arch Pharmacol 1987; 336(2): 232-239.
    • (1987) Naunyn Schmiedebergs Arch Pharmacol , vol.336 , Issue.2 , pp. 232-239
    • Tesseraux, I.1    Gülden, M.2    Wassermann, O.3
  • 14
    • 0142072093 scopus 로고    scopus 로고
    • Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1
    • Vagts AJ, He DY, Yaka R, Ron D. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcohol Clin Exp Res 2003; 27(10): 1599-1605.
    • (2003) Alcohol Clin Exp Res , vol.27 , Issue.10 , pp. 1599-1605
    • Vagts, A.J.1    He, D.Y.2    Yaka, R.3    Ron, D.4
  • 15
    • 0035052106 scopus 로고    scopus 로고
    • Ethanol effects on nitric oxide production in cerebral pial cultures
    • Shih CL, Chi SI, Chiu TH, Sun GY, Lin TN. Ethanol effects on nitric oxide production in cerebral pial cultures. Alcohol Clin Exp Res 2001; 25(4): 612-618.
    • (2001) Alcohol Clin Exp Res , vol.25 , Issue.4 , pp. 612-618
    • Shih, C.L.1    Chi, S.I.2    Chiu, T.H.3    Sun, G.Y.4    Lin, T.N.5
  • 16
    • 0029938970 scopus 로고    scopus 로고
    • Ethanol at pharmacologically relevant concentrations inhibits contractility of isolated smooth muscle cells of cat esophagus
    • Keshavarzian A, Muska B, Sundaresan R, Urban G, Fields J. Ethanol at pharmacologically relevant concentrations inhibits contractility of isolated smooth muscle cells of cat esophagus. Alcohol Clin Exp Res 1996; 20(1): 180-184.
    • (1996) Alcohol Clin Exp Res , vol.20 , Issue.1 , pp. 180-184
    • Keshavarzian, A.1    Muska, B.2    Sundaresan, R.3    Urban, G.4    Fields, J.5
  • 17
    • 0028243137 scopus 로고
    • Regulatory potential of ethanol and retinoic acid on human monocyte functions
    • Szabo G, Puppolo M, Verma B, Catalano D. Regulatory potential of ethanol and retinoic acid on human monocyte functions. Alcohol Clin Exp Res 1994; 18(3): 548-554.
    • (1994) Alcohol Clin Exp Res , vol.18 , Issue.3 , pp. 548-554
    • Szabo, G.1    Puppolo, M.2    Verma, B.3    Catalano, D.4
  • 18
    • 0024374724 scopus 로고
    • Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia
    • Sargent JM, Taylor CG. Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia. Br J Cancer 1989; 60(2): 206-210.
    • (1989) Br J Cancer , vol.60 , Issue.2 , pp. 206-210
    • Sargent, J.M.1    Taylor, C.G.2
  • 19
    • 0030895726 scopus 로고    scopus 로고
    • Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect
    • Berti L, Kellerer M, Capp E, Häring HU. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia 1997; 40(5): 606-609.
    • (1997) Diabetologia , vol.40 , Issue.5 , pp. 606-609
    • Berti, L.1    Kellerer, M.2    Capp, E.3    Häring, H.U.4
  • 20
    • 0029800475 scopus 로고    scopus 로고
    • Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle
    • Wojtaszewski JF, Hansen BF, Ursø B, Richter EA. Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle. J Appl Physiol 1996; 81(4): 1501-1509.
    • (1996) J Appl Physiol , vol.81 , Issue.4 , pp. 1501-1509
    • Wojtaszewski, J.F.1    Hansen, B.F.2    Ursø, B.3    Richter, E.A.4
  • 21
    • 24144456191 scopus 로고    scopus 로고
    • Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP
    • Wan Q, Liu Y, Guan Q, Gao L, Lee KO, Zhao J. Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP. Alcohol Clin Exp Res 2005; 29(8): 1450-1456.
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.8 , pp. 1450-1456
    • Wan, Q.1    Liu, Y.2    Guan, Q.3    Gao, L.4    Lee, K.O.5    Zhao, J.6
  • 22
    • 33744955437 scopus 로고    scopus 로고
    • Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation
    • He L, Simmen FA, Mehendale HM, Ronis MJ, Badger TM. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J Biol Chem 2006; 281(16): 11126-11134.
    • (2006) J Biol Chem , vol.281 , Issue.16 , pp. 11126-11134
    • He, L.1    Simmen, F.A.2    Mehendale, H.M.3    Ronis, M.J.4    Badger, T.M.5
  • 23
    • 67349255861 scopus 로고    scopus 로고
    • PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair
    • Pang M, de la Monte SM, Longato L, et al. PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair. J Hepatol 2009; 50(6): 1192-1201.
    • (2009) J Hepatol , vol.50 , Issue.6 , pp. 1192-1201
    • Pang, M.1    de la Monte, S.M.2    Longato, L.3
  • 24
    • 77749233737 scopus 로고    scopus 로고
    • Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes
    • Feng L, Song YF, Guan QB, et al. Long-term ethanol exposure inhibits glucose transporter 4 expression via an AMPK-dependent pathway in adipocytes. Acta Pharmacol Sin 2010; 31(3): 329-340.
    • (2010) Acta Pharmacol Sin , vol.31 , Issue.3 , pp. 329-340
    • Feng, L.1    Song, Y.F.2    Guan, Q.B.3
  • 25
    • 34948831425 scopus 로고    scopus 로고
    • Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health
    • He L, Marecki JC, Serrero G, Simmen FA, Ronis MJ, Badger TM. Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol Endocrinol 2007; 21(10): 2541-2550.
    • (2007) Mol Endocrinol , vol.21 , Issue.10 , pp. 2541-2550
    • He, L.1    Marecki, J.C.2    Serrero, G.3    Simmen, F.A.4    Ronis, M.J.5    Badger, T.M.6
  • 26
    • 0033636971 scopus 로고    scopus 로고
    • Ethanol stimulates glucose uptake and translocation of GLUT-4 in H9c2 myotubes via a Ca(2 + )-dependent mechanism
    • Yu B, Schroeder A, Nagy LE. Ethanol stimulates glucose uptake and translocation of GLUT-4 in H9c2 myotubes via a Ca(2 + )-dependent mechanism. Am J of Physiol Endocrinol Metab 2000; 279(6): E1358-E1365.
    • (2000) Am J of Physiol Endocrinol Metab , vol.279 , Issue.6
    • Yu, B.1    Schroeder, A.2    Nagy, L.E.3
  • 27
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
    • Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998; 333(Pt 3): 471-490.
    • (1998) Biochem J , vol.333 , Issue.PART 3 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 28
    • 33644832891 scopus 로고    scopus 로고
    • Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance
    • Cornier MA, Bessesen DH, Gurevich I, Leitner JW, Draznin B. Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance. Diabetologia 2006; 49(4): 748-754.
    • (2006) Diabetologia , vol.49 , Issue.4 , pp. 748-754
    • Cornier, M.A.1    Bessesen, D.H.2    Gurevich, I.3    Leitner, J.W.4    Draznin, B.5
  • 30
    • 27844460627 scopus 로고    scopus 로고
    • Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
    • Barbour LA, Mizanoor Rahman S, Gurevich I, et al. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. J Biol Chem 2005; 280(45): 37489-37494.
    • (2005) J Biol Chem , vol.280 , Issue.45 , pp. 37489-37494
    • Barbour, L.A.1    Mizanoor Rahman, S.2    Gurevich, I.3
  • 31
    • 1442348156 scopus 로고    scopus 로고
    • Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle
    • Barbour LA, Shao J, Qiao L, et al. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology 2004; 145(3): 1144-1150.
    • (2004) Endocrinology , vol.145 , Issue.3 , pp. 1144-1150
    • Barbour, L.A.1    Shao, J.2    Qiao, L.3
  • 32
    • 0032869972 scopus 로고    scopus 로고
    • Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E
    • Lang CH, Wu D, Frost RA, Jefferson LS, Kimball SR, Vary TC. Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E. Am J Physiol 1999; 277(2): E268-E276.
    • (1999) Am J Physiol , vol.277 , Issue.2
    • Lang, C.H.1    Wu, D.2    Frost, R.A.3    Jefferson, L.S.4    Kimball, S.R.5    Vary, T.C.6
  • 33
    • 0035896366 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt)-a key regulator of glucose transport?
    • Hajduch E, Litherland GJ, Hundal HS. Protein kinase B (PKB/Akt)-a key regulator of glucose transport?. FEBS Lett 2001; 492(3): 199-203.
    • (2001) FEBS Lett , vol.492 , Issue.3 , pp. 199-203
    • Hajduch, E.1    Litherland, G.J.2    Hundal, H.S.3
  • 34
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    • Cho H, Mu J, Kim JK, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001; 292(5522): 1728-1731.
    • (2001) Science , vol.292 , Issue.5522 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3
  • 35
    • 14944381279 scopus 로고    scopus 로고
    • Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications
    • Zdychová J, Komers R. Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications. Physiol Res 2005; 54(1): 1-16.
    • (2005) Physiol Res , vol.54 , Issue.1 , pp. 1-16
    • Zdychová, J.1    Komers, R.2
  • 36
    • 0036550053 scopus 로고    scopus 로고
    • 3'-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling
    • Storz P, Toker A. 3'-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. Fron Biosci 2002; 7: d886-d902.
    • (2002) Fron Biosci , vol.7
    • Storz, P.1    Toker, A.2
  • 37
    • 0034984029 scopus 로고    scopus 로고
    • Insulin-sensitive phospholipid signaling systems and glucose transport. Update II
    • Farese RV. Insulin-sensitive phospholipid signaling systems and glucose transport. Update II. Exp Biol Med (Maywood) 2001; 226(4): 283-295.
    • (2001) Exp Biol Med (Maywood) , vol.226 , Issue.4 , pp. 283-295
    • Farese, R.V.1
  • 38
    • 0033834248 scopus 로고    scopus 로고
    • Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    • Zisman A, Peroni OD, Abel ED, et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 2000; 6(8): 924-928.
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 924-928
    • Zisman, A.1    Peroni, O.D.2    Abel, E.D.3
  • 39
    • 77950539263 scopus 로고    scopus 로고
    • Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium
    • Chen L, Wang F, Sun X, et al. Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. Exp Mol Med 2010; 42(3): 205-215.
    • (2010) Exp Mol Med , vol.42 , Issue.3 , pp. 205-215
    • Chen, L.1    Wang, F.2    Sun, X.3


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