Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 702-714

  Jang, Mi Yeon ^a   Jonghe, Steven De ^a   Segers, Kenneth ^a   Anné, Jozef ^a   Herdewijn, Piet ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

ATPase; Bacterial preprotein secretion; Inhibitor; SecA; Thiazolo 4,5 d pyrimidines

Indexed keywords

1 [4 (2,5 DIAMINOTHIAZOLO[4,5 D]PYRIMIDIN 7 YL)PIPERAZIN 1 YL]ETHANONE; 1 [4 (2,6 DIAMINOPYRIMIDIN 4 YL)PIPERAZIN 1 YL]ETHANONE; 1 [4 (5 AMINO 2 CHLOROTHIAZOLO[4,5 D]PYRIMIDIN 7 YL]PIPERAZIN 1 YL)ETHANONE; 1 [4 [5 AMINO 2 (4 FLUOROPHENYL)THIAZOLO[4,5 D]PYRIMIDIN 7 YL]PIPERAZIN 1 YL]ETHANONE; 1 [4 [5 AMINO 2 (4 FLUOROPHENYL)THIAZOLO[4,5 D]PYRIMIDIN7 YL]PIPERAZIN 1 YL] 2 (4 CHLOROPHENOXY)ETHANONE; 2 (4 FLUOROPHENYL) 7 (ISOPENTYLOXY)THIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 2 (4 FLUOROPHENYL) 7 (PIPERAZIN 1 YL)THIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 2 (4 FLUOROPHENYL) 7 MORPHOLINOTHIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 2 BROMO 7 (ISOPENTYLOXY)THIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 2 BROMO 7 ETHOXYTHIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 2 BROMO 7 MORPHOLINOTHIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 2,7 DIMORPHOLINOTHIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 4 [5 AMINO 2 (4 FLUOROPHENYL)THIAZOLO[4,5 D]PYRIMIDIN 7 YL] N 3 TOLYLPIPERAZINE 1 CARBOXAMIDE; 5 AMINO THIAZOLO[4,5 D]PYRIMIDINE; 6 (ISOPENTYLOXY) 5 THIOCYANATOPYRIMIDINE 2,4 DIAMINE; 6 (ISOPENTYLOXY)PYRIMIDINE 2,4 DIAMINE; 6 ETHOXY 5 THIOCYANATOPYRIMIDINE 2,4 DIAMINE; 6 ETHOXYPYRIMIDINE 2,4 DIAMINE; 6 MORPHOLINO 5 THIOCYANATOPYRIMIDINE 2,4 DIAMINE; 7 (ISOPENTYLOXY)THIAZOLO[4,5 D]PYRIMIDINE 2,5 DIAMINE; 7 ETHOXY 2 (4 FLUOROPHENYL)THIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 7 ETHOXYTHIAZOLO[4,5 D]PYRIMIDINE 2,5 DIAMINE; 7 MORPHOLINO 2 PHENYLTHIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 7 MORPHOLINO 2 STYRYLTHIAZOLO[4,5 D]PYRIMIDIN 5 AMINE; 7 MORPHOLINOTHIAZOLO[4,5 D]PYRIMIDINE 2,5 DIAMINE; 7 ORPHOLINO 2 (PHENYLETHYNYL)THIAZOLO[4,5 D]PYRIMIN 5 AMINE; ADENOSINE TRIPHOSPHATASE INHIBITOR; N 2 (2 METHOXYETHYL) 7 MORPHOLINOTHIAZOLO[4,5 D]PYRIMIDINE 2,5 DIAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ADENOSINE TRIPHOSPHATASES; BACTERIAL PROTEINS; ESCHERICHIA COLI; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MEMBRANE TRANSPORT PROTEINS; PYRIMIDINES; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 78650736474     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.027     Document Type: Article

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