SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2731-2734

  Hunt, Fraser ^a   Austin, Caroline ^a   Austin, Rupert ^a   Bonnert, Roger ^a   Cage, Peter ^a   Christie, Jadeen ^a   Christie, Mark ^a   Dixon, Clare ^a   Hill, Steven ^a   Jewell, Robert ^a   Martin, Ian ^a   Robinson, David ^a   Willis, Paul ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

CXCR2; Thiazolopyrimidine

Indexed keywords

BENZYL DERIVATIVE; CHEMOKINE RECEPTOR CXCR2; HALIDE; PYRIMIDINE DERIVATIVE; SULFONE; THIAZOLO[4,5 D]PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; CORRELATION ANALYSIS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; RATS; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 34247366027     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.080     Document Type: Article

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