The synthesis of aminopyridines: A method employing palladium-catalyzed carbon-nitrogen bond formation

Journal of Organic Chemistry

Volumn 61, Issue 21, 1996, Pages 7240-7241

  Wagaw, Seble ^a   Buchwald, Stephen L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; PYRIDINE DERIVATIVE;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0029905037     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9612739     Document Type: Article

References (25)

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22. 1H NMR spectrum of the [(R)-tol-BINAP]Pd(4-benzonitrile)(Br) complex remained unchanged.
23. (b) Widenhoefer, R. A.; Buchwald S. L. Unpublished results.
24. These substrates instead afforded predominantly imine and pyridine, presumably formed from β-hydride elimination of the corresponding palladium-amido intermediate.
25. 4, and concentrated in vacuo to give the crude product. Purification by flash column chromatography afforded the analytically pure product.