Synthesis of a covalent gemcitabine-(carbamate)-[anti-HER2/neu] immunochemotherapeutic and its cytotoxic anti-neoplastic activity against chemotherapeutic-resistant SKBr-3 mammary carcinoma

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 67-76

  Coyne, C P ^a   Jones, Toni ^a   Pharr, Todd ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Cell ELISA; Chemotherapeutic resistant mammary carcinoma; Cytotoxic anti neoplastic potency; Gemcitabine; Gemcitabine (carbamate) anti HER2 neu ; HER2 neu; Synthesis

Indexed keywords

ANTHRACYCLINE; ANTIBODY CONJUGATE; CARBAMIC ACID DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; GEMCITABINE; IMMUNOGLOBULIN G; ISOCYANATE; LYSINE; MONOCLONAL ANTIBODY; PARAPROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; LEUKEMIA; LUNG SMALL CELL CANCER; LYMPHOMA; MOLECULAR WEIGHT; MOUTH CARCINOMA; NEUROBLASTOMA; PANCREAS CARCINOMA; PLASMA HALF LIFE; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; DEOXYCYTIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, ERBB-2; HUMANS; IMMUNOCONJUGATES;

EID: 78650720713     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.046     Document Type: Article

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