Pentacyclic triterpenoids and ceramide mediate the vasorelaxant activity of Vitex cienkowskii via involvement of NO/cGMP pathway in isolated rat aortic rings

Journal of Ethnopharmacology

Volumn 133, Issue 1, 2011, Pages 204-212

  Dongmo, Alain Bertrand ^a,e   Azebaze, Anatole Guy Blaise ^a   Donfack, Flaure Metchi ^b   Dimo, Théophile ^b   Nkeng Efouet, Pepin Alango ^c   Devkota, Krishna Prasad ^d,g   Sontia, Bruno ^e   Wagner, Hildebert ^f   Sewald, Norbert ^d   Vierling, Wolfgang ^e  

^a UNIVERSITY OF DOUALA   (Cameroon)

^b UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^c UNIVERSITY OF DSCHANG   (Cameroon)

^d BIELEFELD UNIVERSITY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f Institute of Pharmaceutical Biology   (Germany)

^g Institute of Forestry   (Nepal)

Author keywords

Aortic smooth muscle; cGMP; Nitric oxide; Pentacyclic triterpenoids; Relaxation; Vitex cienkowskii

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ANTIHYPERTENSIVE AGENT; ASCORBIC ACID; CERAMIDE; CYCLIC GMP; DICHLOROMETHANE; GUANYLATE CYCLASE; INDOMETACIN; MASLINIC ACID; METHANOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORADRENALIN; PENTACYCLIC TRITERPENE; PLANT EXTRACT; SALVIN; SALVIN A; UNCLASSIFIED DRUG; VASODILATOR AGENT; VITEX CIENKOWSKII EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; ETHNOPHARMACOLOGY; HEART RATE; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION; VITEX; VITEX CIENKOWSKII;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; CAMEROON; CERAMIDES; CYCLIC GMP; FREE RADICAL SCAVENGERS; HEART RATE; HYPERTENSION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PENTACYCLIC TRITERPENES; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; RATS; VASODILATOR AGENTS; VITEX;

CAVIA; RATTUS; VITEX;

EID: 78650679159     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.09.033     Document Type: Article

References (55)

1. U.V. Ahmad, J. Hussain, H. Hussain, U. Farooq, E. Akber, S.A. Nawaz, and M.I. Choudhary Two Ceramides from Tanacetum artemesioides Zeitschrift für Naturforschung B 59 2004 329 333
2. M.I. Alam, and A. Gomes Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts Journal of Ethnopharmacology 86 2003 75 80
3. O.I. Aruoma Free radicals, oxidative stress, and antioxidants in human health and disease Journal of the American Oil Chemists' Society 75 1998 199 212
4. N Backhouse, L. Rosales, C. Apablaza, L. Göity, S. Erazo, R. Negrete, C. Theodolu, J. Rodriguez, and C. Delporte Analgesic, anti-inflammatory and antioxidant properties of Buddleja globosa, Buddlejaceae Journal of Ethnopharmacology 116 2008 263 269
5. D. Berger, W. Schaffner, E. Schrader, B. Meier, and A. Brattström Efficacy of Vitex agnus-castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS) Archives of Gynaecology and Obstetrics 264 2000 150 153
6. S. Chericoni, L. Testai, V. Calderone, G. Flamini, P. Nieri, I. Morelli, and E. Martinotti The xanthones Gentiacaulein and Gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana Planta Medica 69 2003 770 772
7. Correa, M.P., 1926. Dicionário das Plantas ú teis do Brasil e das Exóticas CultivadasP, Imprensa Nacional, Rio de Janeiro, vol. IV, p. 208.
8. A.B. Dongmo, D.G. Dzikouk, L.D. Massoma, T.B. Nguelefak, C. Vardamides, A. Kamanyi, and W. Vierling Antioxidant and vasorelaxant activities of the antioxidant and vasorelaxant activities of the Turraeanthus africanus methanol extract Pharmaceutical Biology 47 2009 1123 1129
9. M.G. Dharmasiri, J.R.A.C. Jayakody, G. Galhena, S.S.P. Liyanage, and W.D. Ratnasooriya Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo Journal of Ethnopharmacology 87 2003 199 206
10. I. Fourcade, P. Paule, and B. Mafart Hypertension artérielle en Afrique susaharienne actualité et perspectives Medecine Tropicale 67 2007 559 567
11. A. Friebe, and D. Koesling Regulation of nitric oxide-sensitive guanylyl cyclase Circulation Research 93 2003 96 105
12. J. Gao, J. Chen, X. Tang, L. Pan, L. Xu, L. Zhao, and Q. Xu Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice Journal of Pharmacy and Pharmacology 58 2006 227 233
13. L.J. Goad, and Y. Akihisa Analysis of Sterols first edition 1997 Blackie Academic & Professional Weinheim pp. 378-380
14. T. Godfraind, R. Miller, and M. Wibo Calcium antagonism and calcium entry blockade Pharmacological Reviews 38 1986 321 416
15. M. Gupta, U.K. Mazumder, and S.R. Bhawal CNS activity of Vitex negundo Linn. in mice Indian Journal of Experimental Biology 37 1999 143 146
16. Z. Hajdú, J. Hohmann, P. Forgo, T. Martinek, M. Dervarics, I. Zupkó, G. Falkay, D. Cossuta, and M. Imre Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents Phytotherapy Research 21 2007 391 394
17. M.M. Hernandez, C. Heraso, M.L. Villarreal, I. Vargas-Arispuro, and E. Aranda Biological activities of crude plant extracts from Vitex trifolia L. (Verbenaceae) Journal of Ethnopharmacology 67 1999 37 44
18. C. Hirobe, Z.S. Qiao, K. Takeya, and H. Itokawa Cytotoxic flavonoids from Vitex agnus-castus Phytochemistry 46 1997 521 524
19. E. Hoberg, J. Orjala, B. Meier, and O. Sticher Diterpenoids from the fruits of Vitex agnus-castus Phytochemistry 52 1999 1555 1558
20. M.M. Hossain, N. Paul, M.H. Sohrab, E. Rahman, and M.A. Rashid Antibacterial activity of Vitex trifolia Fitoterapia 72 2001 695 697
21. W.F. Jackson, A. Konig, and T. Dambacher Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels. American Journal of Physiology, Heart and Circulatory Physiology 264 1993 H238 H243
22. N.D. Kim, S.Y. Kang, and V.B. Schini Gingenosides evoke endothelium-dependent vascular relaxation in rat aorta General Pharmacology 25 1994 1071 1077
23. G. Kizil, M. Kizil, M. Yavuz, S. Emen, and F. Hakimoglu Antioxidant activities of ethanol extracts of Hypericum triquetrifolium and Hypericum scabroides Pharmaceutical Biology 46 2008 231 242
24. A. Kuruüzüm-Uz, K. Ströch, L.Ö. Demirezer, and A. Zeeck Glucosides from Vitex agnus-castus Phytochemistry 63 2003 959 964
25. O. Ladeji, Z.S.C. Okoye, and F. Uddoh Effects of Vitex doniana stem bark extract on blood pressure Phytotherapy Research 10 1996 245 247 (Pubitemid 26164575)
26. 13C NMR Spectra of pentacyclic triterpenoids - a compilation and some salient features Phytochemistry 37 1994 1517 1575
27. G. Mancia, M. Bombelli, A. Lanzarotti, G. Grassi, G. Cesana, A. Zanchetti, and R. Sega Systolic vs. distolic blood pressure control in the hypertensive patients of the PAMELA population Archives of Internal Medicine 162 2002 582 586
28. S. Mehmood, N. Riaz, S.A. Nawaz, N. Afza, A. Malikl, and M.I. Choudhary New butyrylcholinesterase inhibitory triterpenes from Salvia santolinifolia Archives of Pharmacal Research 29 2006 195 198
29. H.D. Neuwinger African Traditional Medicine: A Dictionary of Plant Use and Applications 2000 Medpharm Scientific Publishers Stuttgart
30. e cycle en chimie organique, Faculté des Sciences, Université de Yaoundé, Cameroun.
31. M. Ono, H. Sawamura, Y. Ito, K. Mizuki, and T. Nohara Diterpenoids from the fruits of Vitex trifolia Phytochemistry 55 2000 873 877
32. M. Ono, M. Yamamoto, T. Yanaka, Y. Ito, and T. Nohara Ten new labdane-type diterpenes from the fruit of Vitex rotundifolia Chemical Pharmaceutical Bulletin 49 2001 82 86
33. G. Pei-Wu, Y. Fukuyama, W. Rei, B. Jinxian, and K. Nakagawa An acylated sitosterol glucoside from Alisma plantago-aquatica Phytochemistry 27 1988 1895 1896
34. H. Parkington, H.A. Coleman, and M. Tare Prostacyclin and endotheliumdependent hyperpolarization Pharmacological Research 49 2004 509 514
35. N.S. Ramazanov Ecdysteroids and iridoidal glycosides from Vitex agnus-castus Chemical and Natural Products 40 2004 299
36. R. Rodríguez-Rodríguez, M.D. Herrera, J.S. Perona, and V. Ruiz-Gutiérrez Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta British Journal of Nutrition 92 2004 635 642
37. G.M. Rubanyi The role of endothelium in cardiovascular homeostasis and diseases Journal of Cardiovascular Pharmacology 22 1993 S1 S14
38. R.P. Samy, S. Ignacimuthu, and A. Sen Screening of 34 Indian medicinal plants for antibacterial properties Journal of Ethnopharmacology 62 1998 173 182
39. Sontia, B., 2005. Einfluss von Pflanzen-Extrakten (Vitex cienkowskii und Daniella oliveri) und physiologischen Ionen auf die glatte Gefässmuskulatur und elektrophysiologische Eigenschaften des Herzmuskels. Dissertation an der Medizinischen Fakultät der Ludwig-Maximilians-Universität zu München.
40. J.M. Sorensen, and S.T. Katsiotis Parameters influencing the yield and composition of the essential oil from Cretan Vitex agnus-castus fruits Planta Medica 66 2000 245 250
41. K.A. Steinmetz, and J.D. Potter Vegetables, fruit, and cancer prevention: a review Journal of the American Dietetic Association 96 1996 1027 1039
42. S Taniguchi, Y. Imayoshi, E. Kobayashi, Y. Takamatsu, H. Ito, T. Hatano, H. Sakagami, H. Tokuda, H. Nishino, D. Sugita, S. Shimura, and T. Yoshida Production of bioactive triterpenes by Eriobotrya japonica calli Phytochemistry 59 2002 315 323
43. M.A. Tanner, X. Bu, J.A. Steimle, and P.R. Myers The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum Nitric Oxide 3 1999 359 365
44. K. Thaipong, U. Boonprakob, L. Cisneros-Zevallos, and D.H. Byrne Hydrophilic and lipophilic antioxidant activities of guava fruits Southeast Asian Journal of Tropical Medicine & Public Health 36 2005 254 257
45. O. Taiwo, H.X. Xu, and S.F. Lee Antimicrobial activities of extracts from Nigerian chewing sticks Phytotherapy Research 13 1999 675 679
46. W. Vierling, N. Brand, F. Gaedcke, K.H. Sensch, E. Schneider, and M. Scholz Investigation of the pharmaceutical and pharmacological equivalence of different Hawthorn extracts Phytomedicine 10 2003 8 16
47. Y. Wang, S. Jian-Gong, M.Z. Wang, C. Chun-Tao, and H.K. John Mechanisms of the vasorelaxant effect of 1-hydroxy-2, 3,5-trimethoxy-xanthone, isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery Life Sciences 81 2007 1016 1023
48. WHO, 2005. Les maladies cardio-vasculaires dans la région africaine: situation actuelle et perspectives, AFR/RC55/12, pp. 1-9.
49. E. Wollenweber, and K. Mann Flavonols from fruits of Vitex agnus-castus Planta Medica 47 1983 126 127
50. H. Xiangjiu, and H.L. Rui Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially Responsible for apple's anticancer activity Journal of Agricultural and Food Chemistry 55 2007 4366 4370
51. Q. Xiong, S. Kadota, T. Tani, and T. Namba Antioxidative effects of phenylethanoids from Cistanche deserticola Biological and Pharmaceutical Bulletin 19 1996 1580 1585
52. T. Yamagishi, D. Zhang, J. Chang, D. Mcphail, A.T. Mcphail, and K.H. Lees The cytotoxic principles of Hyptis capitata and the Structures of the new triterpenes hyptatic acid-A and -B Phytochemistry 27 1988 3213 3216
53. X. Yan, T. Nagata, and X. Fa Antioxidative activities in some common seaweeds Plant Foods for Human Nutrition 52 1998 253 262
54. K.M. You, K.H. Son, H.W. Chang, S.S. Kang, and H.P. Kim Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro Planta Medica 64 1998 546 550
55. i in canine cerebral vascular smooth muscle Neuroscience Letters 256 1998 113 116