Detection of trace crystallinity in an amorphous system using Raman microscopy and chemometric analysis

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 1-2, 2011, Pages 45-54

  Widjaja, Effendi ^a   Kanaujia, Parijat ^a   Lau, Grace ^a   Ng, Wai Kiong ^a   Garland, Marc ^a   Saal, Christoph ^c   Hanefeld, Andrea ^c   Fischbach, Matthias ^c   Maio, Mario ^c   Tan, Reginald B H ^a,b  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NONE   (Germany)

Author keywords

Active pharmaceutical ingredients; Amorphous; Band target entropy minimization; Formulation; Hot melt extrusion; Polymorphism; Raman microscopy; Target transformation factor analysis; Trace crystallinity

Indexed keywords

FENOFIBRATE; GRISEOFULVIN;

ALGORITHM; ANALYTIC METHOD; ARTICLE; BAND TARGET ENTROPY MINIMIZATION; CHEMOMETRIC ANALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISPERSION; DRUG DISTRIBUTION; DRUG PURITY; FACTORIAL ANALYSIS; POWDER DIFFRACTION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; TARGET TRANSFORMATION FACTOR ANALYSIS; X RAY DIFFRACTION;

ALGORITHMS; CRYSTALLIZATION; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; ENTROPY; FENOFIBRATE; MICROSCOPY; MICROSCOPY, ELECTRON, SCANNING; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; SPECTRUM ANALYSIS, RAMAN; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 78650676702     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.10.004     Document Type: Article

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