Hepatic accumulation of intestinal cholesterol is decreased and fecal cholesterol excretion is increased in mice fed a high-fat diet supplemented with milk phospholipids

Nutrition and Metabolism

Volumn 7, Issue , 2010, Pages

  Kamili, Alvin ^a   Wat, Elaine ^a,c   Chung, Rosanna Ws ^a   Tandy, Sally ^a   Weir, Jacquelyn M ^b   Meikle, Peter J ^b   Cohn, Jeffrey S ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CERAMIDE; CHOLESTEROL; CHOLESTEROL C 14; FECES LIPID; MILK FAT; MONOHEXOSYLCERAMIDE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SITOSTANOL; SITOSTANOL H 3; TRIACYLGLYCEROL; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTESTINE ABSORPTION; ISOTOPE LABELING; LIPID ABSORPTION; LIPID DIET; LIPID LIVER LEVEL; MALE; MILK; MOUSE; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL;

MUS;

EID: 78650661465     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-7-90     Document Type: Article

References (30)

1. Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease. JS Cohn E Wat A Kamili S Tandy, Curr Opin Lipidol 2008 19 257 262 10.1097/MOL.0b013e3282ffaf96 18460916
2. Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet. E Wat S Tandy E Kapera A Kamili RW Chung A Brown M Rowney JS Cohn, Atherosclerosis 2009 205 144 150 10.1016/j.atherosclerosis.2008.12.004 19159882
3. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. S Tandy RW Chung E Wat A Kamili K Berge M Griinari JS Cohn, J Agric Food Chem 2009 57 9339 9345 10.1021/jf9016042 19761211
4. Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet. S Tandy RWS Chung A Kamili E Wat JM Weir PJ Meikle JS Cohn, Atherosclerosis 2010 213 142 147 10.1016/j.atherosclerosis.2010. 07.050 20832797
5. Dietary phospholipids and intestinal cholesterol absorption. JS Cohn A Kamili E Wat RWS Chung S Tandy, Nutrients 2010 2 116 127 10.3390/nu2020116
6. Egg phosphatidylcholine decreases the lymphatic absorption of cholesterol in rats. Y Jiang SK Noh SI Koo, J Nutr 2001 131 2358 2363 11533279
7. Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats. SK Noh SI Koo, J Nutr 2004 134 2611 2616 15465755
8. Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers. ER Eckhardt DQ Wang JM Donovan MC Carey, Gastroenterology 2002 122 948 956 10.1053/gast.2002.32539 11910347
9. Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies. DQ Wang MC Carey, J Lipid Res 2003 44 1042 1059 10.1194/jlr.D200041-JLR200 12588946
10. Phosphatidylcholine hydrolysis is required for pancreatic cholesterol esterase- and phospholipase A2-facilitated cholesterol uptake into intestinal Caco-2 cells. K Mackay JR Starr RM Lawn JL Ellsworth, J Biol Chem 1997 272 13380 13389 10.1074/jbc.272.20.13380 9148961
11. Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice. BL Richmond AC Boileau S Zheng KW Huggins NA Granholm P Tso DY Hui, Gastroenterology 2001 120 1193 1202 10.1053/gast.2001.23254 11266383
12. Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2. R Homan KL Hamelehle, J Lipid Res 1998 39 1197 1209 9643351
13. NPC1L1 and SR-BI are involved in intestinal cholesterol absorption from small-size lipid donors. Z Haikal B Play JF Landrier A Giraud O Ghiringhelli D Lairon D Jourdheuil-Rahmani, Lipids 2008 43 401 408 10.1007/s11745-008-3172-7 18373109
14. Transintestinal cholesterol efflux. AE van der Velde G Brufau AK Groen, Curr Opin Lipidol 2010 21 167 171 10.1097/MOL.0b013e3283395e45 20410820
15. Regulation of direct transintestinal cholesterol excretion in mice. AE van der Velde CL Vrins K van den Oever I Seemann RP Oude Elferink M van Eck F Kuipers AK Groen, Am J Physiol Gastrointest Liver Physiol 2008 295 203 G208 10.1152/ajpgi.90231.2008 18511744
16. A mutual inhibitory effect on absorption of sphingomyelin and cholesterol. L Nyberg RD Duan A Nilsson, J Nutr Biochem 2000 11 244 249 10.1016/S0955-2863(00)00069-3 10876096
17. C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. SA Schreyer DL Wilson RC LeBoeuf, Atherosclerosis 1998 136 17 24 10.1016/S0021-9150(97)00165-2 9544727
18. The effect of lecithin on intestinal cholesterol uptake by rat intestine in vitro. AJ Rampone, J Physiol 1973 229 505 514 4724834
19. Intestinal cholesterol uptake: comparison between mixed micelles containing lecithin or lysolecithin. MO Reynier H Lafont C Crotte P Sauve A Gerolami, Lipids 1985 20 145 150 10.1007/BF02534246 3990523
20. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. DJ Peet SD Turley W Ma BA Janowski JM Lobaccaro RE Hammer DJ Mangelsdorf, Cell 1998 93 693 704 10.1016/S0092-8674(00) 81432-4 9630215
21. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. W Chen G Chen DL Head DJ Mangelsdorf DW Russell, Cell Metab 2007 5 73 79 10.1016/j.cmet.2006.11.012 17189208
22. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. S Zheng L Hoos J Cook G Tetzloff H Davis Jr M van Heek JJ Hwa, Eur J Pharmacol 2008 584 118 124 10.1016/j.ejphar.2008.01.045 18329014
23. Dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats. K Yunoki M Renaguli M Kinoshita H Matsuyama S Mawatari T Fujino Y Kodama M Sugiyama M Ohnishi, J Agric Food Chem 2010 58 7030 7035 10.1021/jf100722f 20443604
24. Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice. I Duivenvoorden PJ Voshol PC Rensen W van Duyvenvoorde JA Romijn JJ Emeis LM Havekes WF Nieuwenhuizen, Am J Clin Nutr 2006 84 312 321 16895877
25. Generating ceramide from sphingomyelin by alkaline sphingomyelinase in the gut enhances sphingomyelin-induced inhibition of cholesterol uptake in Caco-2 cells. D Feng L Ohlsson W Ling A Nilsson RD Duan, Dig Dis Sci 2010 55 3377 3383 10.1007/s10620-010-1202-9
26. Sphingolipids: players in the pathology of metabolic disease. LA Cowart, Trends Endocrinol Metab 2009 20 34 42 10.1016/j.tem.2008.09.004 19008117
27. Sphingolipids and insulin resistance: the five Ws. SA Summers, Curr Opin Lipidol 2010 21 128 135 10.1097/MOL.0b013e3283373b66 20216312
28. Studies on plasma lipoproteins during absorption of exogenous lecithin in man. FU Beil SM Grundy, J Lipid Res 1980 21 525 536 7400685
29. The effect of polyunsaturated phosphatidylcholine on plasma lipids and fecal sterol excretion. H Greten H Raetzer A Stiehl G Schettler, Atherosclerosis 1980 36 81 88 10.1016/0021-9150(80)90201-4 7387779
30. Effects of dietary polyenylphosphatidylcholine on metabolism of cholesterol and triglycerides in hypertriglyceridemic patients. YA Kesaniemi SM Grundy, Am J Clin Nutr 1986 43 98 107 3942098