Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 51, 2010, Pages 22207-22212

  Giallourakis, Cosmas C ^a,c   Franklin, Andrew ^a   Guo, Chunguang ^a   Cheng, Hwei Ling ^a   Yoon, Hye Suk ^a   Gallagher, Michael ^a   Perlot, Thomas ^a   Andzelm, Milena ^a   Murphy, Andrew J ^d   MacDonald, Lynn E ^d   Yancopoulos, George D ^d   Alt, Frederick W ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; GENE DELETION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GERM LINE; MOUSE; NONHUMAN; NUCLEIC ACID PROBE; PRIORITY JOURNAL; T LYMPHOCYTE;

ALLELES; ANIMALS; B-LYMPHOCYTES; DNA, INTERGENIC; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENETIC LOCI; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, MUTANT STRAINS; RNA, ANTISENSE; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

MUS;

EID: 78650641780     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015954107     Document Type: Article

References (47)

1. Schatz DG (2004) V(D)J recombination. Immunol Rev 200:5-11.
2. Jung D, Giallourakis C, Mostoslavsky R, Alt FW (2006) Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol 24:541-570.
3. Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW (1986) Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase. Cell 44:251-259.
4. Schatz DG, Baltimore D (2004) Uncovering the V(D)J recombinase. Cell 116:S103-S106.
5. Fugmann SD, Lee AI, Shockett PE, Villey IJ, Schatz DG (2000) The RAG proteins and V(D)J recombination: Complexes, ends, and transposition. Annu Rev Immunol 18:495-527.
6. Jung D, Alt FW (2004) Unraveling V(D)J recombination; insights into gene regulation. Cell 116:299-311.
7. Rooney S, Chaudhuri J, Alt FW (2004) The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev 200:115-131.
8. Yancopoulos GD, Alt FW (1986) Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol 4:339-368.
9. Krangel MS (2003) Gene segment selection in V(D)J recombination: Accessibility and beyond. Nat Immunol 4:624-630.
10. Alt FW, et al. (1984) Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J 3:1209-1219.
11. Yancopoulos GD, et al. (1984) Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 311:727-733.
12. von Boehmer H (1990) Developmental biology of T cells in T cell-receptor transgenic mice. Annu Rev Immunol 8:531-556.
13. Mostoslavsky R, Alt FW, Rajewsky K (2004) The lingering enigma of the allelic exclusion mechanism. Cell 118:539-544.
14. Yancopoulos GD, Alt FW (1985) Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40:271-281.
15. Corcoran AE (2010) The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generation. Semin Immunol, 10.1016/j.smim.2010.08.001.
16. Subrahmanyam R, Sen R (2010) RAGs' eye view of the immunoglobulin heavy chain gene locus. Semin Immunol, 10.1016/j.smim.2010.08.003.
17. Bolland DJ, et al. (2007) Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Mol Cell Biol 27:5523-5533.
18. Chakraborty T, et al. (2007) Repeat organization and epigenetic regulation of the DHCmu domain of the immunoglobulin heavy-chain gene locus. Mol Cell 27:842-850.
19. Feeney A (2010) Epigenetic regulation of V(D)J recombination. Semin Immunol, 10.1016/j.smim.2010.09.002.
20. Ji Y, et al. (2010) The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 141:419-431.
21. Jhunjhunwala S, et al. (2008) The 3D structure of the immunoglobulin heavy-chain locus: Implications for long-range genomic interactions. Cell 133:265-279.
22. Hewitt SL, et al. (2008) Association between the Igk and Igh immunoglobulin loci mediated by the 3′ Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells. Nat Immunol 9:396-404.
23. Roldán E, et al. (2005) Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol 6:31-41.
24. Degner-Leisso SC, Feeney AJ (2010) Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes. Semin Immunol, 10.1016/j.smim.2010.08.002.
25. Featherstone K, Wood AL, Bowen AJ, Corcoran AE (2010) The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination. J Biol Chem 285:9327-9338.
26. Bates JG, Cado D, Nolla H, Schlissel MS (2007) Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination. J Exp Med 204:3247-3256.
27. Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302:575-581.
28. Degner SC, Wong TP, Jankevicius G, Feeney AJ (2009) Cutting edge: Developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol 182:44-48.
29. Chowdhury M, et al. (2008) Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus. Proc Natl Acad Sci USA 105:15872-15877.
30. Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA (2003) Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci USA 100:11577-11582.
31. Valenzuela DM, et al. (2003) High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21:652-659.
32. Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW (1992) Interleukin-7 induces Nmyc and c-myc expression in normal precursor B lymphocytes. Genes Dev 6:61-70.
33. Abarrategui I, Krangel MS (2007) Noncoding transcription controls downstream promoters to regulate T-cell receptor α recombination. EMBO J 26:4380-4390.
34. Born W, White J, Kappler J, Marrack P (1988) Rearrangement of IgH genes in normal thymocyte development. J Immunol 140:3228-3232.
35. Sleckman BP, Bardon CG, Ferrini R, Davidson L, Alt FW (1997) Function of the TCR α enhancer in αβ and γδ T cells. Immunity 7:505-515.
36. Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D (1981) Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: Rearrangement of heavy but not light chain genes. Cell 27:381-390.
37. Wuerffel R, et al. (2007) S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity 27:711-722.
38. Souabni A, Jochum W, Busslinger M (2007) Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood 109:281-289.
39. Fuxa M, et al. (2004) Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev 18:411-422.
40. Latos PA, Barlow DP (2009) Regulation of imprinted expression by macro non-coding RNAs. RNA Biol 6:100-106.
41. Malecová B, Morris KV (2010) Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs. Curr Opin Mol Ther 12:214-222.
42. Mohammad F, Mondal T, Kanduri C (2009) Epigenetics of imprinted long noncoding RNAs. Epigenetics 4:277-286.
43. Bolland DJ, et al. (2004) Antisense intergenic transcription in V(D)J recombination. Nat Immunol 5:630-637.
44. Preker P, et al. (2008) RNA exosome depletion reveals transcription upstream of active human promoters. Science 322:1851-1854.
45. Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW (1992) Transcriptional downregulation of N-myc expression during B-cell development. Mol Cell Biol 12:1578-1584.
46. Perlot T, Li G, Alt FW (2008) Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci USA 105:3843-3848.
47. Sakai E, Bottaro A, Davidson L, Sleckman BP, Alt FW (1999) Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc Natl Acad Sci USA 96:1526-1531.