-
1
-
-
0029849620
-
Cancer cell cycles
-
Sherr, C. J. (1996) Cancer cell cycles Science 274, 1672-1677
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
2
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres, M. and Barbacid, M. (2001) To cycle or not to cycle: a critical decision in cancer Nat. Rev. Cancer 1, 222-231
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
3
-
-
0037238799
-
Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit
-
McInnes, C., Andrews, M. J. I., Zheleva, D. I., Lane, D. P., and Fischer, P. M. (2003) Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit Curr. Med. Chem.: Anti-Cancer Agents 3, 57-69
-
(2003)
Curr. Med. Chem.: Anti-Cancer Agents
, vol.3
, pp. 57-69
-
-
McInnes, C.1
Andrews, M.J.I.2
Zheleva, D.I.3
Lane, D.P.4
Fischer, P.M.5
-
5
-
-
0033551066
-
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
-
Chen, Y. N., Sharma, S. K., Ramsey, T. M., Jiang, L., Martin, M. S., Baker, K., Adams, P. D., Bair, K. W., and Kaelin, W.G., Jr. (1999) Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists Proc. Natl. Acad. Sci. U.S.A. 96, 4325-4329
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 4325-4329
-
-
Chen, Y.N.1
Sharma, S.K.2
Ramsey, T.M.3
Jiang, L.4
Martin, M.S.5
Baker, K.6
Adams, P.D.7
Bair, K.W.8
Kaelin Jr., W.G.9
-
6
-
-
0032167631
-
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
-
Schulman, B. A., Lindstrom, D. L., and Harlow, E. (1998) Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A Proc. Natl. Acad. Sci. U.S.A. 95, 10453-10458
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 10453-10458
-
-
Schulman, B.A.1
Lindstrom, D.L.2
Harlow, E.3
-
7
-
-
0031025385
-
Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1
-
Ball, K. L., Lain, S., Fåhraeus, R., Smythe, C., and Lane, D. P. (1996) Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1 Curr. Biol. 7, 71-80
-
(1996)
Curr. Biol.
, vol.7
, pp. 71-80
-
-
Ball, K.L.1
Lain, S.2
Fåhraeus, R.3
Smythe, C.4
Lane, D.P.5
-
8
-
-
0037374549
-
Selective cyclin-dependent kinase 2/cyclin A antagonists that differ from atp site inhibitors block tumor growth
-
Mendoza, N., Fong, S., Marsters, J., Koeppen, H., Schwall, R., and Wickramasinghe, D. (2003) Selective cyclin-dependent kinase 2/cyclin A antagonists that differ from atp site inhibitors block tumor growth Cancer Res. 63, 1020-1024
-
(2003)
Cancer Res.
, vol.63
, pp. 1020-1024
-
-
Mendoza, N.1
Fong, S.2
Marsters, J.3
Koeppen, H.4
Schwall, R.5
Wickramasinghe, D.6
-
9
-
-
0036136668
-
Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control
-
Oelgeschlager, T. (2002) Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control J. Cell. Physiol. 190, 160-169
-
(2002)
J. Cell. Physiol.
, vol.190
, pp. 160-169
-
-
Oelgeschlager, T.1
-
10
-
-
19044371037
-
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors
-
Fischer, P. M. and Gianella-Borradori, A. (2005) Recent progress in the discovery and development of cyclin-dependent kinase inhibitors Expert Opin. Invest. Drugs 14, 457-477
-
(2005)
Expert Opin. Invest. Drugs
, vol.14
, pp. 457-477
-
-
Fischer, P.M.1
Gianella-Borradori, A.2
-
11
-
-
33747872306
-
A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
-
Baughn, L. B., Di Liberto, M., Wu, K., Toogood, P. L., Louie, T., Gottschalk, R., Niesvizky, R., Cho, H., Ely, S., Moore, M. A., and Chen-Kiang, S. (2006) A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6 Cancer Res. 66, 7661-7667
-
(2006)
Cancer Res.
, vol.66
, pp. 7661-7667
-
-
Baughn, L.B.1
Di Liberto, M.2
Wu, K.3
Toogood, P.L.4
Louie, T.5
Gottschalk, R.6
Niesvizky, R.7
Cho, H.8
Ely, S.9
Moore, M.A.10
Chen-Kiang, S.11
-
12
-
-
9444228344
-
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
-
Fry, D. W., Harvey, P. J., Keller, P. R., Elliott, W. L., Meade, M., Trachet, E., Albassam, M., Zheng, X., Leopold, W. R., Pryer, N. K., and Toogood, P. L. (2004) Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts Mol. Cancer Ther. 3, 1427-1438
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1427-1438
-
-
Fry, D.W.1
Harvey, P.J.2
Keller, P.R.3
Elliott, W.L.4
Meade, M.5
Trachet, E.6
Albassam, M.7
Zheng, X.8
Leopold, W.R.9
Pryer, N.K.10
Toogood, P.L.11
-
13
-
-
30344470210
-
Requirement for CDK4 kinase function in breast cancer
-
Yu, Q., Sicinska, E., Geng, Y., Ahnstrom, M., Zagozdzon, A., Kong, Y., Gardner, H., Kiyokawa, H., Harris, L. N., Stal, O., and Sicinski, P. (2006) Requirement for CDK4 kinase function in breast cancer Cancer Cell 9, 23-32
-
(2006)
Cancer Cell
, vol.9
, pp. 23-32
-
-
Yu, Q.1
Sicinska, E.2
Geng, Y.3
Ahnstrom, M.4
Zagozdzon, A.5
Kong, Y.6
Gardner, H.7
Kiyokawa, H.8
Harris, L.N.9
Stal, O.10
Sicinski, P.11
-
14
-
-
30344479175
-
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
-
Landis, M. W., Pawlyk, B. S., Li, T., Sicinski, P., and Hinds, P. W. (2006) Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis Cancer Cell 9, 13-22
-
(2006)
Cancer Cell
, vol.9
, pp. 13-22
-
-
Landis, M.W.1
Pawlyk, B.S.2
Li, T.3
Sicinski, P.4
Hinds, P.W.5
-
15
-
-
0345096518
-
Insights into cyclin groove recognition: Complex crystal structures and inhibitor design through ligand exchange
-
Kontopidis, G., Andrews, M. J. I., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D. I., Lane, D. P., Green, S., Walkinshaw, M. D., and Fischer, P. M. (2003) Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange Structure 11, 1537-1546
-
(2003)
Structure
, vol.11
, pp. 1537-1546
-
-
Kontopidis, G.1
Andrews, M.J.I.2
McInnes, C.3
Cowan, A.4
Powers, H.5
Innes, L.6
Plater, A.7
Griffiths, G.8
Paterson, D.9
Zheleva, D.I.10
Lane, D.P.11
Green, S.12
Walkinshaw, M.D.13
Fischer, P.M.14
-
16
-
-
6344240541
-
Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes
-
Andrews, M. J. I., McInnes, C., Kontopidis, G., Innes, L., Cowan, A., Plater, A., and Fischer, P. M. (2004) Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes Org. Biomol. Chem. 2, 2735-2341
-
(2004)
Org. Biomol. Chem.
, vol.2
, pp. 2735-2341
-
-
Andrews, M.J.I.1
McInnes, C.2
Kontopidis, G.3
Innes, L.4
Cowan, A.5
Plater, A.6
Fischer, P.M.7
-
17
-
-
33845395240
-
REPLACE: A strategy for iterative design of cyclin-binding groove inhibitors
-
Andrews, M. J., Kontopidis, G., McInnes, C., Plater, A., Innes, L., Cowan, A., Jewsbury, P., and Fischer, P. M. (2006) REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors ChemBioChem 7, 1909-1915
-
(2006)
ChemBioChem
, vol.7
, pp. 1909-1915
-
-
Andrews, M.J.1
Kontopidis, G.2
McInnes, C.3
Plater, A.4
Innes, L.5
Cowan, A.6
Jewsbury, P.7
Fischer, P.M.8
-
18
-
-
0033224309
-
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
-
Brown, N. R., Noble, M. E., Endicott, J. A., and Johnson, L. N. (1999) The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases Nat. Cell Biol. 1, 438-443
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 438-443
-
-
Brown, N.R.1
Noble, M.E.2
Endicott, J.A.3
Johnson, L.N.4
-
19
-
-
63149148791
-
Crystal structure of human CDK4 in complex with a D-type cyclin
-
Day, P. J., Cleasby, A., Tickle, I. J., O'Reilly, M., Coyle, J. E., Holding, F. P., McMenamin, R. L., Yon, J., Chopra, R., Lengauer, C., and Jhoti, H. (2009) Crystal structure of human CDK4 in complex with a D-type cyclin Proc. Natl. Acad. Sci. U.S.A. 106, 4166-4170
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 4166-4170
-
-
Day, P.J.1
Cleasby, A.2
Tickle, I.J.3
O'Reilly, M.4
Coyle, J.E.5
Holding, F.P.6
McMenamin, R.L.7
Yon, J.8
Chopra, R.9
Lengauer, C.10
Jhoti, H.11
-
20
-
-
63149111417
-
The structure of CDK4/cyclin D3 has implications for models of CDK activation
-
Takaki, T., Echalier, A., Brown, N. R., Hunt, T., Endicott, J. A., and Noble, M. E. (2009) The structure of CDK4/cyclin D3 has implications for models of CDK activation Proc. Natl. Acad. Sci. U.S.A. 106, 4171-4176
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 4171-4176
-
-
Takaki, T.1
Echalier, A.2
Brown, N.R.3
Hunt, T.4
Endicott, J.A.5
Noble, M.E.6
-
21
-
-
67749106463
-
Truncation and optimization of peptide inhibitors of cyclin-dependent kinase 2-cyclin a through structure-guided design
-
Kontopidis, G., Andrews, M. J., McInnes, C., Plater, A., Innes, L., Renachowski, S., Cowan, A., and Fischer, P. M. (2009) Truncation and optimization of peptide inhibitors of cyclin-dependent kinase 2-cyclin a through structure-guided design ChemMedChem 4, 1120-1128
-
(2009)
ChemMedChem
, vol.4
, pp. 1120-1128
-
-
Kontopidis, G.1
Andrews, M.J.2
McInnes, C.3
Plater, A.4
Innes, L.5
Renachowski, S.6
Cowan, A.7
Fischer, P.M.8
-
22
-
-
32044437649
-
CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads
-
Castanedo, G., Clark, K., Wang, S., Tsui, V., Wong, M., Nicholas, J., Wickramasinghe, D., Marsters, J. C., Jr., and Sutherlin, D. (2006) CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads Bioorg. Med. Chem. Lett. 16, 1716-1720
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1716-1720
-
-
Castanedo, G.1
Clark, K.2
Wang, S.3
Tsui, V.4
Wong, M.5
Nicholas, J.6
Wickramasinghe, D.7
Marsters Jr., J.C.8
Sutherlin, D.9
-
23
-
-
42449087261
-
Switching cyclin D-Cdk4 kinase activity on and off
-
Blain, S. W. (2008) Switching cyclin D-Cdk4 kinase activity on and off Cell Cycle 7, 892-898
-
(2008)
Cell Cycle
, vol.7
, pp. 892-898
-
-
Blain, S.W.1
-
24
-
-
37549061066
-
Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity
-
James, M. K., Ray, A., Leznova, D., and Blain, S. W. (2008) Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity Mol. Cell. Biol. 28, 498-510
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 498-510
-
-
James, M.K.1
Ray, A.2
Leznova, D.3
Blain, S.W.4
-
25
-
-
59449106702
-
P27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes
-
Ray, A., James, M. K., Larochelle, S., Fisher, R. P., and Blain, S. W. (2009) p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes Mol. Cell. Biol. 29, 986-999
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 986-999
-
-
Ray, A.1
James, M.K.2
Larochelle, S.3
Fisher, R.P.4
Blain, S.W.5
-
26
-
-
0029665852
-
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
-
Russo, A. A., Jeffrey, P. D., Patten, A. K., Massague, J., and Pavletich, N. P. (1996) Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex Nature 382, 325-331
-
(1996)
Nature
, vol.382
, pp. 325-331
-
-
Russo, A.A.1
Jeffrey, P.D.2
Patten, A.K.3
Massague, J.4
Pavletich, N.P.5
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