Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit

Current Medicinal Chemistry - Anti-Cancer Agents

Volumn 3, Issue 1, 2003, Pages 57-69

  McInnes, Campbell ^a   Andrews, Martin J I ^a   Zheleva, Daniella I ^a   Lane, David P ^a   Fischer, Peter M ^a  

^a CYCLACEL LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANYLALANYL 2 AMINOBUTYRATE ARGINYLARGINYLLEUCYLISOLEUCYL 4 FLUOROPHENYLALANYLAMIDE; ALANYLALANYL 2 AMINOBUTYRATE ARGINYLSERYLLEUCYLISOLEUCYL 4 FLUOROPHENYLALANYLAMIDE; ALANYLALANYLLYSYLARGINYLARGINYLLEUCYLALANYL 4 FLUOROPHENYLALANYLAMIDE; ALANYLALANYLLYSYLARGINYLSERYLLEUCYLISOLEUCYL 4 FLUOROPHENYLALANYLAMIDE; CARRIER PROTEIN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; ENZYME INHIBITOR; PROTEIN INHIBITOR; PROTEIN P21; PROTEIN P27; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BINDING SITE; CELL MEMBRANE PERMEABILITY; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SUBSTRATE; MALIGNANT TRANSFORMATION; MOLECULAR MIMICRY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEINS;

EID: 0037238799     PISSN: 15680118     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568011033353506     Document Type: Review

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