Truncation and optimisation of peptide inhibitors of cyclin-dependent kinase 2-cyclin A through structure-guided design

ChemMedChem

Volumn 4, Issue 7, 2009, Pages 1120-1128

  Kontopidis, George ^a   Andrews, Martin J ^b   McInnes, Campbell ^c   Plater, Andy ^d   Innes, Lorraine ^d   Renachowski, Scott ^d   Cowan, Angela ^d   Fischer, Peter M ^e  

^a UNIVERSITY OF THESSALY   (Greece)

^b GALAPAGOS NV   (Belgium)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

^d CYCLACEL LTD   (United Kingdom)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Cancer; Cyclin groove inhibitors; Cyclin dependent kinases; Peptidomimetics; Structure based drug design

Indexed keywords

BETA AMINO ACID; CYCLIN A; CYCLIN DEPENDENT KINASE 2; DIPEPTIDE; ENZYME INHIBITOR;

ARTICLE; BINDING AFFINITY; BIOASSAY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; DRUG DESIGN; HUMANS; PEPTIDES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67749106463     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900093     Document Type: Article

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