Halogenated β,γ-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase β: SStructural evidence for stereospecific binding of the fluoromethylene analogues

Journal of the American Chemical Society

Volumn 132, Issue 22, 2010, Pages 7617-7625

  Batra, Vinod K ^a   Pedersen, Lars C ^a   Beard, William A ^a   Wilson, Samuel H ^a   Kashemirov, Boris A ^b   Upton, Thomas G ^b   Goodman, Myron F ^b   McKenna, Charles E ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BASE EXCISION REPAIRS; CARBON ATOMS; CHIRAL CENTERS; DIASTEREOMERS; DNA POLYMERASE; ENZYME COMPLEXES; FLUORINE ATOMS; GUANIDINIUM; NATURAL SUBSTRATES; ONCOGENESIS; REPAIR ENZYMES; STEREOSPECIFIC; STERIC EFFECT; STRUCTURAL DATA; STRUCTURAL EVIDENCE; TERNARY COMPLEX;

COMPLEXATION; DNA; ENZYMES; FLUORINE; GENES; NUCLEOTIDES; SUBSTRATES; TABLE LOOKUP;

ATOMS;

ARGININE; CARBENE; CARBON; DNA; DNA DIRECTED DNA POLYMERASE BETA; FLUORINE; GUANIDINE; GUANOSINE TRIPHOSPHATE; NUCLEOTIDE;

ARTICLE; CHEMICAL BINDING; CHEMICAL STRUCTURE; CONFORMATION; DIASTEREOISOMER; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA; DNA POLYMERASE BETA; GUANOSINE TRIPHOSPHATE; HALOGENATION; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 77953104442     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja909370k     Document Type: Article

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