Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 19, 2008, Pages 5249-5251

  Guckian, Kevin M ^a   Lin, Edward Yin Shiang ^a   Silvian, Laura ^a   Friedman, Jessica E ^a   Chin, Donovan ^a   Scott, Daniel M ^a  

^a BIOGEN   (United States)

Author keywords

i Domain; ICAM; LFA 1; LFA 1 ICAM inhibitors

Indexed keywords

ANILINE DERIVATIVE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANILINE COMPOUNDS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; INHIBITORY CONCENTRATION 50; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MOLECULAR CONFORMATION; RATS; STEREOISOMERISM;

EID: 52049090546     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.061     Document Type: Article

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