Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5567-5570

  Bohl, Casey E ^a   Wu, Zengru ^a   Chen, Jiyun ^a   Mohler, Michael L ^b   Yang, Jun ^a   Hwang, Dong Jin ^b   Mustafa, Suni ^b   Miller, Duane D ^b   Bell, Charles E ^a   Dalton, James T ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Androgen receptor; Cachexia; Crystallography; Prostate cancer; SARM

Indexed keywords

PROPIONAMIDE DERIVATIVE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TRYPTOPHAN;

ANDROGEN BLOOD LEVEL; ARTICLE; B RING; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG STRUCTURE; HORMONE RECEPTOR INTERACTION; HYDROGEN BOND; HYDROPHILICITY; MUSCLE ATROPHY; NONHUMAN; OSTEOPOROSIS; SUBSTITUTION REACTION;

AMIDES; CACHEXIA; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; MALE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MUSCLES; OSTEOPOROSIS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANDROGEN;

EID: 53349166988     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.002     Document Type: Article

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