메뉴 건너뛰기




Volumn 25, Issue 28, 2005, Pages 6658-6666

Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain

Author keywords

Apoptosis; Caspase; Cell death; Disinhibition; Microglia; TUNEL

Indexed keywords

ADAPTOR PROTEIN; CALCIUM BINDING ADAPTER MOLECULE 1; CALCIUM BINDING PROTEIN; CASPASE 3; UNCLASSIFIED DRUG;

EID: 22244446763     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1490-05.2005     Document Type: Article
Times cited : (127)

References (55)
  • 1
    • 0036708173 scopus 로고    scopus 로고
    • Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse
    • Araki T, Simon RP, Taki W, Lan JQ, Henshall DC (2002) Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse. J Neurosci Res 69:614-621.
    • (2002) J Neurosci Res , vol.69 , pp. 614-621
    • Araki, T.1    Simon, R.P.2    Taki, W.3    Lan, J.Q.4    Henshall, D.C.5
  • 2
    • 0031844349 scopus 로고    scopus 로고
    • Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons
    • Azkue JJ, Zimmermann M, Hsieh T-F, Herdegen T (1998) Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons. Eur J Neurosci 10:2204-2206.
    • (1998) Eur J Neurosci , vol.10 , pp. 2204-2206
    • Azkue, J.J.1    Zimmermann, M.2    Hsieh, T.-F.3    Herdegen, T.4
  • 3
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107.
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 4
    • 0027500127 scopus 로고
    • Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical disector
    • Bjugn R, Gundersen HJ (1993) Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical disector. J Comp Neurol 328:406-414.
    • (1993) J Comp Neurol , vol.328 , pp. 406-414
    • Bjugn, R.1    Gundersen, H.J.2
  • 5
    • 0023924048 scopus 로고
    • Myelinated afferents signal the hyperalgesia associated with nerve injury
    • Campbell JN, Raja SN, Meyer RA, Mackinnon SE (1988) Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain 32:89-94.
    • (1988) Pain , vol.32 , pp. 89-94
    • Campbell, J.N.1    Raja, S.N.2    Meyer, R.A.3    Mackinnon, S.E.4
  • 6
    • 0027242053 scopus 로고
    • GABA decreases in the spinal cord dorsal horn after peripheral neurectomy
    • Castro-Lopes JM, Tavares I, Coimbra A (1993) GABA decreases in the spinal cord dorsal horn after peripheral neurectomy. Brain Res 620:287-291.
    • (1993) Brain Res , vol.620 , pp. 287-291
    • Castro-Lopes, J.M.1    Tavares, I.2    Coimbra, A.3
  • 8
    • 0026567764 scopus 로고
    • A consideration of neural counting methods
    • Coggeshall RE (1992) A consideration of neural counting methods. Trends Neurosci 15:9-13.
    • (1992) Trends Neurosci , vol.15 , pp. 9-13
    • Coggeshall, R.E.1
  • 9
    • 0035797125 scopus 로고    scopus 로고
    • A-fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord
    • Coggeshall RE, Lekan HA, White FA, Woolf CJ (2001) A-fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord. J Comp Neurol 435:276-282.
    • (2001) J Comp Neurol , vol.435 , pp. 276-282
    • Coggeshall, R.E.1    Lekan, H.A.2    White, F.A.3    Woolf, C.J.4
  • 10
    • 0037110607 scopus 로고    scopus 로고
    • Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat
    • Davoli MA, Fourtounis J, Tam J, Xanthoudakis S, Nicholson D, Robertson GS, Ng GY, Xu D (2002) Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat. Neuroscience 115:125-136.
    • (2002) Neuroscience , vol.115 , pp. 125-136
    • Davoli, M.A.1    Fourtounis, J.2    Tam, J.3    Xanthoudakis, S.4    Nicholson, D.5    Robertson, G.S.6    Ng, G.Y.7    Xu, D.8
  • 11
    • 0034255439 scopus 로고    scopus 로고
    • Spared nerve injury: An animal model of persistent peripheral neuropathic pain
    • Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149-158.
    • (2000) Pain , vol.87 , pp. 149-158
    • Decosterd, I.1    Woolf, C.J.2
  • 12
    • 10744226450 scopus 로고    scopus 로고
    • Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early overexpression of pro-apoptotic genes and morphological changes in dorsal horn lamina II
    • de Novellis V, Siniscalo D, Galderisi U, Fuccio R, Nolano M, Santoro L, Cascino A, Roth KA, Rossi N, Maione S (2004) Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early overexpression of pro-apoptotic genes and morphological changes in dorsal horn lamina II. Neuropharmacology 46:468-479.
    • (2004) Neuropharmacology , vol.46 , pp. 468-479
    • De Novellis, V.1    Siniscalo, D.2    Galderisi, U.3    Fuccio, R.4    Nolano, M.5    Santoro, L.6    Cascino, A.7    Roth, K.A.8    Rossi, N.9    Maione, S.10
  • 13
    • 0018867072 scopus 로고
    • Efficient analysis of experimental observations
    • Dixon WJ (1980) Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441-462.
    • (1980) Annu Rev Pharmacol Toxicol , vol.20 , pp. 441-462
    • Dixon, W.J.1
  • 14
    • 0032448274 scopus 로고    scopus 로고
    • Changes in GAD- and GABA-immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplants of immortalized serotoninergic precursors
    • Eaton MJ, Plunkett JA, Karmally S, Martinez MA, Montanez K (1998) Changes in GAD- and GABA-immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplants of immortalized serotoninergic precursors. J Chem Neuroanat 16:57-72.
    • (1998) J Chem Neuroanat , vol.16 , pp. 57-72
    • Eaton, M.J.1    Plunkett, J.A.2    Karmally, S.3    Martinez, M.A.4    Montanez, K.5
  • 15
    • 0027428024 scopus 로고
    • A quantitative analysis of microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat
    • Eriksson NP, Persson JK, Svensson M, Arvidsson J, Molander C, Aldskogius H (1993) A quantitative analysis of microglial cell reaction in central primary sensory projection territories following peripheral nerve injury in the adult rat. Exp Brain Res 96:19-27.
    • (1993) Exp Brain Res , vol.96 , pp. 19-27
    • Eriksson, N.P.1    Persson, J.K.2    Svensson, M.3    Arvidsson, J.4    Molander, C.5    Aldskogius, H.6
  • 16
    • 0029068714 scopus 로고
    • Microglial turnover in the injured CNS: Activated microglia undergo delayed DNA fragmentation following peripheral nerve injury
    • Gehrmann J, Banati R (1995) Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 54:680-688.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 680-688
    • Gehrmann, J.1    Banati, R.2
  • 17
    • 0025737140 scopus 로고
    • Spinal cord microglial cells and DRG satellite cells rapidly respond to transection of the rat sciatic nerve
    • Gehrmann J, Monaco S, Kreutzberg GW (1991) Spinal cord microglial cells and DRG satellite cells rapidly respond to transection of the rat sciatic nerve. Restor Neurol Neurosci 2:181-198.
    • (1991) Restor Neurol Neurosci , vol.2 , pp. 181-198
    • Gehrmann, J.1    Monaco, S.2    Kreutzberg, G.W.3
  • 18
    • 0037140798 scopus 로고    scopus 로고
    • On counting and counting errors
    • Guillery RW (2002) On counting and counting errors. J Comp Neurol 447:1-7.
    • (2002) J Comp Neurol , vol.447 , pp. 1-7
    • Guillery, R.W.1
  • 19
    • 0345017009 scopus 로고    scopus 로고
    • Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury
    • Hoang TX, Nieto JH, Tillakaratne NJ, Havton LA (2003) Autonomic and motor neuron death is progressive and parallel in a lumbosacral ventral root avulsion model of cauda equina injury. J Comp Neurol 467:477-486.
    • (2003) J Comp Neurol , vol.467 , pp. 477-486
    • Hoang, T.X.1    Nieto, J.H.2    Tillakaratne, N.J.3    Havton, L.A.4
  • 20
    • 0033048814 scopus 로고    scopus 로고
    • The apoptosis cascade-morphological and immunohistochemical methods for its visualization
    • Huppertz B, Frank H-G, Kaufmann (1999) The apoptosis cascade- morphological and immunohistochemical methods for its visualization. Anat Embryol 200:1-18.
    • (1999) Anat Embryol , vol.200 , pp. 1-18
    • Huppertz, B.1    Frank, H.-G.2    Kaufmann3
  • 21
    • 0030580562 scopus 로고    scopus 로고
    • Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts
    • Ibuki T, Hama AT, Wang X-T, Pappas GD, Sagen J (1997) Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts. Neuroscience 76:845-858.
    • (1997) Neuroscience , vol.76 , pp. 845-858
    • Ibuki, T.1    Hama, A.T.2    Wang, X.-T.3    Pappas, G.D.4    Sagen, J.5
  • 22
    • 0030601207 scopus 로고    scopus 로고
    • A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    • Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S (1996) A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 224:855-862.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 855-862
    • Imai, Y.1    Ibata, I.2    Ito, D.3    Ohsawa, K.4    Kohsaka, S.5
  • 25
    • 0030608825 scopus 로고    scopus 로고
    • Prostaglandin E1 prevents apoptotic cell death in superficial dorsal horn of rat spinal cord
    • Kawamura T, Akira T, Watanabe M, Kagitani Y (1997) Prostaglandin E1 prevents apoptotic cell death in superficial dorsal horn of rat spinal cord. Neuropharmacology 36:1023-1030.
    • (1997) Neuropharmacology , vol.36 , pp. 1023-1030
    • Kawamura, T.1    Akira, T.2    Watanabe, M.3    Kagitani, Y.4
  • 26
    • 0028235568 scopus 로고
    • Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain
    • Koltzenburg M, Torebjork HE, Wahren LK (1994) Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain 117:579-591.
    • (1994) Brain , vol.117 , pp. 579-591
    • Koltzenburg, M.1    Torebjork, H.E.2    Wahren, L.K.3
  • 27
    • 0141836884 scopus 로고    scopus 로고
    • Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain
    • Korhonen L, Belluardo N, Mudo G, Lindholm D (2003) Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain. Eur J Neurosci 18:1121-1134.
    • (2003) Eur J Neurosci , vol.18 , pp. 1121-1134
    • Korhonen, L.1    Belluardo, N.2    Mudo, G.3    Lindholm, D.4
  • 28
    • 1942521024 scopus 로고    scopus 로고
    • Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats
    • Lei B, Popp S, Capuano-Waters C, Cottrell JE, Kass IS (2004) Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats. Neuroscience 125:691-701.
    • (2004) Neuroscience , vol.125 , pp. 691-701
    • Lei, B.1    Popp, S.2    Capuano-Waters, C.3    Cottrell, J.E.4    Kass, I.S.5
  • 29
    • 0015903435 scopus 로고
    • Investigation of glial cells in semithin sections. I. Identification of glial cells in the brain of young rats
    • Ling EA, Paterson JA, Privat A, Mori S, Leblond CP (1973) Investigation of glial cells in semithin sections. I. Identification of glial cells in the brain of young rats. J Comp Neurol 149:43-72.
    • (1973) J Comp Neurol , vol.149 , pp. 43-72
    • Ling, E.A.1    Paterson, J.A.2    Privat, A.3    Mori, S.4    Leblond, C.P.5
  • 31
    • 0036759656 scopus 로고    scopus 로고
    • Neuronal apoptosis associated with morphine tolerance: Evidence for an opioid-induced neurotoxic mechanism
    • Mao J, Sung B, Ji RR, Lim G (2002) Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci 22:7650-7661.
    • (2002) J Neurosci , vol.22 , pp. 7650-7661
    • Mao, J.1    Sung, B.2    Ji, R.R.3    Lim, G.4
  • 32
    • 0037083204 scopus 로고    scopus 로고
    • Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent
    • Martin LJ, Liu Z (2002) Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent. J Neurobiol 50:181-197.
    • (2002) J Neurobiol , vol.50 , pp. 181-197
    • Martin, L.J.1    Liu, Z.2
  • 33
    • 0021711550 scopus 로고
    • The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord
    • Molander C, Xu Q, Grant G (1984) The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J Comp Neurol 230:133-141.
    • (1984) J Comp Neurol , vol.230 , pp. 133-141
    • Molander, C.1    Xu, Q.2    Grant, G.3
  • 34
    • 0036703985 scopus 로고    scopus 로고
    • Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord
    • Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H, Woolf CJ (2002) Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci 22:6724-6731.
    • (2002) J Neurosci , vol.22 , pp. 6724-6731
    • Moore, K.A.1    Kohno, T.2    Karchewski, L.A.3    Scholz, J.4    Baba, H.5    Woolf, C.J.6
  • 35
    • 0026697724 scopus 로고
    • NeuN, a neuronal specific nuclear protein in vertebrates
    • Mullen RJ, Buck CR, Smith AM (1992) NeuN, a neuronal specific nuclear protein in vertebrates. Development 116:201-211.
    • (1992) Development , vol.116 , pp. 201-211
    • Mullen, R.J.1    Buck, C.R.2    Smith, A.M.3
  • 36
    • 0028986493 scopus 로고
    • Olfactory experience modulates apoptosis in the developing olfactory bulb
    • Najbauer J, Leon M (1995) Olfactory experience modulates apoptosis in the developing olfactory bulb. Brain Res 674:245-251.
    • (1995) Brain Res , vol.674 , pp. 245-251
    • Najbauer, J.1    Leon, M.2
  • 38
    • 0033119709 scopus 로고    scopus 로고
    • GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord
    • Polgár E, Shehab SAS, Watt C, Todd AJ (1999) GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord. J Neurosci 19:2637-2646.
    • (1999) J Neurosci , vol.19 , pp. 2637-2646
    • Polgár, E.1    Sas, S.2    Watt, C.3    Todd, A.J.4
  • 39
    • 0037485919 scopus 로고    scopus 로고
    • Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain
    • Polgár E, Hughes DI, Riddell JS, Maxwell DJ, Puskár Z, Todd AJ (2003) Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. Pain 104:229-239.
    • (2003) Pain , vol.104 , pp. 229-239
    • Polgár, E.1    Hughes, D.I.2    Riddell, J.S.3    Maxwell, D.J.4    Puskár, Z.5    Todd, A.J.6
  • 40
    • 4344618736 scopus 로고    scopus 로고
    • Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model
    • Polgár E, Gray S, Riddell JS, Todd AJ (2004) Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model. Pain 111:144-150.
    • (2004) Pain , vol.111 , pp. 144-150
    • Polgár, E.1    Gray, S.2    Riddell, J.S.3    Todd, A.J.4
  • 43
    • 0028168576 scopus 로고
    • The contribution of GABAA and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord
    • Sivilotti L, Woolf CJ (1994) The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol 72:169-179.
    • (1994) J Neurophysiol , vol.72 , pp. 169-179
    • Sivilotti, L.1    Woolf, C.J.2
  • 44
    • 0021234096 scopus 로고
    • The unbiased estimation of number and sizes of arbitrary particles using the disector
    • Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-136.
    • (1984) J Microsc , vol.134 , pp. 127-136
    • Sterio, D.C.1
  • 45
    • 0024992879 scopus 로고
    • Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: Effects of a chronic constriction injury, transection, and strychnine
    • Sugimoto T, Bennett GJ, Kajander KC (1990) Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine. Pain 42:205-213.
    • (1990) Pain , vol.42 , pp. 205-213
    • Sugimoto, T.1    Bennett, G.J.2    Kajander, K.C.3
  • 46
    • 15244340126 scopus 로고    scopus 로고
    • Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization
    • Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL (2005) Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem 92:1508-1520.
    • (2005) J Neurochem , vol.92 , pp. 1508-1520
    • Svensson, C.I.1    Fitzsimmons, B.2    Azizi, S.3    Powell, H.C.4    Hua, X.Y.5    Yaksh, T.L.6
  • 49
    • 0033083082 scopus 로고    scopus 로고
    • Stereological methods for estimating the total number of neurons and synapses: Issues of precision and bias
    • West MJ (1999) Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci 22:51-61.
    • (1999) Trends Neurosci , vol.22 , pp. 51-61
    • West, M.J.1
  • 50
    • 0035871969 scopus 로고    scopus 로고
    • Cell death in the superficial dorsal horn in a model of neuropathic pain
    • Whiteside GT, Munglani R (2001) Cell death in the superficial dorsal horn in a model of neuropathic pain. J Neurosci Res 64:168-173.
    • (2001) J Neurosci Res , vol.64 , pp. 168-173
    • Whiteside, G.T.1    Munglani, R.2
  • 51
    • 0024268109 scopus 로고
    • Three-dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material
    • Williams RW, Rakic P (1988) Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material. J Comp Neurol 278:344-352.
    • (1988) J Comp Neurol , vol.278 , pp. 344-352
    • Williams, R.W.1    Rakic, P.2
  • 52
    • 0001028762 scopus 로고    scopus 로고
    • Molecular signals responsible for the reorganization of the synaptic circuitry of the dorsal horn after peripheral nerve injury: The mechanisms of tactile allodynia
    • (Borsook D, ed). Seattle: IASP
    • Woolf CJ (1997) Molecular signals responsible for the reorganization of the synaptic circuitry of the dorsal horn after peripheral nerve injury: the mechanisms of tactile allodynia. In: Molecular neurobiology of pain (Borsook D, ed), pp 171-200. Seattle: IASP.
    • (1997) Molecular Neurobiology of Pain , pp. 171-200
    • Woolf, C.J.1
  • 53
    • 0024602581 scopus 로고
    • Behavioral and anatomic correlates of the tactile-evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
    • Yaksh TL (1989) Behavioral and anatomic correlates of the tactile-evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 37:111-123.
    • (1989) Pain , vol.37 , pp. 111-123
    • Yaksh, T.L.1
  • 54
    • 0036405495 scopus 로고    scopus 로고
    • Comparison of calpain and caspase activities in the adult rat brain after transient forebrain ischemia
    • Zhang C, Siman R, Xu YA, Mills AM, Frederick JR, Neumar RW (2002) Comparison of calpain and caspase activities in the adult rat brain after transient forebrain ischemia. Neurobiol Dis 10:289-305.
    • (2002) Neurobiol Dis , vol.10 , pp. 289-305
    • Zhang, C.1    Siman, R.2    Xu, Y.A.3    Mills, A.M.4    Frederick, J.R.5    Neumar, R.W.6
  • 55
    • 0035840825 scopus 로고    scopus 로고
    • Pathobiology of neuropathic pain
    • Zimmerman M (2001) Pathobiology of neuropathic pain. Eur J Pharmacol 429:23-37.
    • (2001) Eur J Pharmacol , vol.429 , pp. 23-37
    • Zimmerman, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.