Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor receive monosynaptic input from myelinated primary afferents

European Journal of Neuroscience

Volumn 10, Issue 9, 1998, Pages 3012-3019

  Naim, M M ^a   Shehab, S A S ^a   Todd, A J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Confocal microscopy; Electron microscopy; Immunocytochemistry; Pain; Synapse

Indexed keywords

CHOLERA TOXIN B SUBUNIT; NEUROKININ 1 RECEPTOR; SUBSTANCE P;

ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; DENDRITE; ELECTRON MICROSCOPY; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MYELINATED NERVE; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL CORD; SYNAPSE;

ANIMALS; CHOLERA TOXIN; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MYELIN SHEATH; NEURONS, AFFERENT; RATS; RECEPTORS, NEUROKININ-1; SPINAL CORD; SYNAPSES;

EID: 0032466218     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1998.00335.x     Document Type: Article

References (32)

1. 1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons. J. Neurosci., 14, 7655-7664.
2. Brown, A.G. (1981) Organization in the Spinal Cord: the Anatomy and Physiology of Identified Neurones. Springer-Verlag, Berlin.
3. Brown, J.L., Liu, H., Maggio, J.E., Vigna, S.R., Mantyh, P.W. & Basbaum, A.I. (1995) Morphological characterization of substance P receptor-immunoreactive neurons in rat spinal cord and trigeminal nucleus caudalis. J. Comp. NeurOl., 356, 327-344.
4. Doyle, C.A., Palmer, J.A., Munglani, R. & Hunt, S.P. (1997) Molecular consequences of noxious stimulation. In Borsook, D. (ed.), Molecular Neurobiology of Pain. IASP Press, Seattle, pp. 145-169.
5. Gobel, S. (1982) Golgi studies of the neurons in layer II of the dorsal horn of the medulla (trigeminal nucleus caudalis). J. Comp. Neurol., 180, 395-414.
6. LaMotte, C.C., Kapadia, S.E. & Shapiro, C.M. (1991) Central projections of the sciatic, saphenous, median, and ulnar nerves of the rat demonstrated by transganglionic transport of choleragenoid-HRP (B-HRP) and wheat germ agglutinin-HRP (WGA-HRP). J. Comp. Neurol., 311, 546-562.
7. Lawson, S.N., Crepps, B.A. & Perl, E.R. (1997) Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in the guinea-pig. J. Physiol., 505, 177-191.
8. Light, A.R. & Perl, E.R. (1979) Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers. J. Comp. Neurol., 186, 133-150.
9. Littlewood, N.K., Todd, A.J., Spike, R.C., Watt, C. & Shehab, S.A.S. (1995) The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors. Neuroscience, 66, 597-608.
10. Liu, H., Brown, J.L., Jasmin, L., Maggio, J.E., Vigna, S.R., Mantyh, P.W. & Basbaum, A.I. (1994) Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc. Natl. Acad. Sci. USA, 91, 1009-1013.
11. Llewellyn-Smith, I.J. & Minson, J.B. (1992) Complete penetration of antibodies into Vibratome sections after glutaraldehyde fixation and ethanol. treatment: light and electron microscopy for neuropeptides. J. Histochem. Cytochem., 40, 1741-1749.
12. Mantyh, P.W., DeMaster, E., Malhotra, A., Ghilardi, J.R., Rogers, S.D., Mantyh, C.R., Liu, H., Basbaum, A.I., Vigna, S.R., Maggio, J.E. & Simone, D.A. (1995) Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science, 268, 1629-1632.
13. Marshall, G.E., Shehab, S.A.S., Spike, R.C. & Todd, A.J. (1996) Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat. Neuroscience, 72, 255-263.
14. Naim, M., Spike, R.C., Watt, C., Shehab, S.A.S. & Todd, A.J. (1997) Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor and have dorsally-directed dendrites receive a major synaptic input from tachykinin-containing primary afferents. J. Neurosci., 17, 5536-5548.
15. Rethelyi, M., Light, A.R. & Perl, E.R. (1982) Synaptic complexes formed by functionally defined primary afferent units with fine myelinated fibers. J. Comp. Neurol., 207, 381-393.
16. Ribeiro-da-Silva, A. & Coimbra, A. (1982) Two types of synaptic glomeruli and their distribution in laminae I-III of the rat spinal cord. J. Comp. Neurol., 209, 176-186.
17. Ribeiro-da-Silva, A., Tagari, P. & Cuello, A.C. (1989) Morphological characterization of substance P-like immunoreactive glomeruli in the superficial dorsal horn of the rat spinal cord and trigeminal subnucleus caudalis: a quantitative study. J. Comp. Neurol., 281, 497-515.
18. Rivero-Melian, C. & Grant, G. (1990) Distribution of lumbar dorsal root fibres in the lower thoracic and lumbosacral spinal cord of the rat studied with choleragenoid horseradish peroxidase conjugate. J. Comp. Neurol., 299, 470-481.
19. Rivero-Melian, C. & Grant, G. (1991) Choleragenoid horseradish peroxidase used for studying projections of some hindlimb cutaneous nerves and plantar foot afferents to the dorsal horn and Clarke's column in the rat. Exp. Brain Res., 84, 125-132.
20. Rivero-Melian, C., Rosario, C. & Grant, G. (1992) Demonstration of transganglionically transported choleragenoid in rat spinal cord by immunofluorescence cytochemistry. Neurosci. Lett., 145, 114-117.
21. Robertson, B. & Grant, G. (1985) A comparison between wheatgerm agglutinin and choleragenoid-horseradish peroxidase as anterogradely transported markers in central branches of primary sensory neurones in the rat with some observations in the cat. Neuroscience, 14, 895-905.
22. Robertson, B. & Grant, G. (1989) Immunocytochemical evidence for the localization of the GM1 ganglioside in carbonic anhydrase-containing and RT 97-immunoreactive rat primary sensory neurons. J. Neurocytol., 18, 77-86.
23. Robertson, B., Perry, M.J. & Lawson, S.N. (1991) Populations of rat spinal primary afferent neurons with choleragenoid binding compared with those labelled by markers for neurofilament and carbohydrate groups: A quantitative immunocytochemical study. J. Neurocytol., 20, 387-395.
24. Shortland, P. & Woolf, C.J. (1993) Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord. J. Comp. Neurol., 330, 65-92.
25. Sugiura, Y., Lee, C.L. & Perl, E.R. (1987) Central projections of identified, unmyelinated (C) afferent fibres innervating mammalian skin. Science, 234, 358-361.
26. Szentagothai, J. (1964) Neuronal and synaptic arrangement in the substantia gelatinosa Rolandi. J. Comp. Neurol., 122, 219-239.
27. Todd, A.J. (1989) Cells in laminae III and IV of rat spinal dorsal horn receive monosynaptic primary afferent input in lamina II. J. Comp. Neurol., 289, 676-686.
28. Todd, A.J. (1997) A method for combining confocal and electron microscopic examination of sections processed for double- or triple-labelling immunocytochemistry. J. Neurosci. Meth, 73, 149-157.
29. Todd, A.J. & Spike, R.C. (1993) The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn. Prog. Neurobiol., 41, 609-646.
30. Vigna, S.R., Bowden, J.J., McDonald. D.M., Fisher, J., Okamoto, A., McVey, D.C., Payan, D.G. & Bunnett, N.W. (1994) Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J. Neurosci., 14, 834-845.
31. Woolf, C.J., Shortland, P. & Coggeshall, R.E. (1992) Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature, 355, 75-78.
32. Woolf, C.J., Shortland, P., Reynolds, M., Ridings, J., Doubell, T. & Coggeshall, R.E. (1995) Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy. J. Comp. Neurol., 360, 121-134.