Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2- hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 307-319

  Guo, Rui Hua ^a,b   Zhang, Quan ^a   Ma, Yun Bao ^a   Luo, Jie ^a   Geng, Chang An ^a,b   Wang, Li Jun ^a,b   Zhang, Xue Mei ^a   Zhou, Jun ^a   Jiang, Zhi Yong ^a   Chen, Ji Jun ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anti hepatitis B virus activity; Quinolin 2(1H) one; Structure activity relationships

Indexed keywords

2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (2 METHOXYPHENYL)ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (3 FLUOROPHENYL)ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (3 METHOXYPHENYL)ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (3,4 DIMETHOXY PHENYL)ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (4 METHOXYPHENYL)ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (BENZO[D][1,3] DIOXOL 5 YL)ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 [3 (TRIFLUORO METHYL)PHENYL]ACRYLATE; 2 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 [4 (TRIFLUORO METHYL)PHENYL]ACRYLATE; 3 [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]PROPRYL 3 (3 METHOXYPHENYL)ACRYLATE; 6 CHLORO 4 (2 CHLOROPHENYL) 3 (2 HYDROXYETHYL) QUINOLIN 2(1H) ONE DERIVATIVE; [6 CHLORO 4 (2 CHLOROPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL]ETHYL 3 (3 METHOXYPHENYL)ACRYLATE; ANTIVIRUS AGENT; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; DNA REPLICATION; DNA, VIRAL; ENHANCER ELEMENTS, GENETIC; HEP G2 CELLS; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650515608     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.019     Document Type: Article

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