Swerilactones A and B, anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis

Organic Letters

Volumn 11, Issue 18, 2009, Pages 4120-4123

  Geng, Chang An ^a,b   Jiang, Zhi Yong ^a   Ma, Yun Bao ^a   Luo, Jie ^a   Zhang, Xue Mei ^a   Wang, Hong Ling ^a,b   Shen, Yong ^a,b   Zuo, Ai Xue ^a,b   Zhou, Jun ^a   Chen, Ji Jun ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; HEPATITIS B SURFACE ANTIGEN; HEPATITIS C ANTIGEN; HERBACEOUS AGENT; LACTONE; SWERILACTONE A; SWERILACTONE B;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; STRUCTURE ACTIVITY RELATION; SWERTIA; X RAY;

ANTIVIRAL AGENTS; DRUGS, CHINESE HERBAL; HEPATITIS B SURFACE ANTIGENS; HEPATITIS C ANTIGENS; LACTONES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SWERTIA; X-RAYS;

EID: 70349130815     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol901592f     Document Type: Article

References (29)

1. Kao, J. H.; Chen, D. S. Lancet Infect. Dis. 2002, 2, 395-407.
2. Lavanchy, D. J. Viral Hepat. 2004, 11, 97-107.
3. Cooksley, W. G. Semin. Liver Dis. 2004, 24, 45-53.
4. Liaw, Y. F.; Cheung, N. W.; Chang, T. T.; Guan, R.; Tai, D. I.; Ng, K. Y. Gastroenterology 2000, 119, 172-180.
5. Suzuki, F.; Suzuki, Y.; Tsubota, A.; Akuta, N.; Someya, T.; Kobayashi, M.; Saitoh, S.; Arase, Y.; Ikeda, K.; Kumada, H. J. Hepatol. 2003, 37, 824-830.
6. Li, P. T.; Leeuweberg, A. J. M.; Middleton, D. J. Flora of China 1995, 16, 115.
7. Gao, L. Yunnan Zhongyi Zhongyao Zazhi 2006, 27, 65-66.
8. He, R. Y.; Nie, R. L. Acta Bot. Yunnan. 1980, 2, 480-482.
9. He, R. Y.; Feng, S. J.; Nie, R. L. Acta Bot. Yunnan. 1982, 4, 68, 76.
10. Nie, R. L.; He, R. Y. Acta Bot. Yunnan. 1984, 6, 325-328.
11. Kikuzaki, H.; Kitamura, S.; Nakatani, N. Chem Express 1988, 3, 751-754.
12. Zhou, Y.; Di, Y. T.; Gesang, S.; Peng, S. L.; Ding, L. S. Helv Chim. Acta 2006, 89, 94-102.
13. Kikuzaki, H.; Kawasaki, Y.; Kitamura, S.; Nakatani, N. Planta Med. 1996, 62, 35-38.
14. Liu, Z. W.; Chen, C X.; Jin, R. M.; Shi, G. Q.; Song, C Q.; Hu, Z. B. Zhongcaoyao 2002, 33, 47-49.
15. Liang, Q. S.; Gao, X. Y. Zhongcaoyao Tongxun 1979, 9, 1-4.
16. Du, Y.; Li, H. D. Chin. Pharm. 2006, 17, 304-306.
17. Du, G. M.; Li, G. Y. Yunnan Zhongyi Zazhi 1981, 3, 35-44.
18. Contagious Department, 59th Hospital of the Chinese PLA. New Chin. Med 1975, 4, 202.
19. 50 = 36.2 mM, SI < 1).
20. Jiang, Z. Y.; Zhang, X. M.; Zhang, F. X.; Liu, N.; Zhao, F.; Zhou, J.; Chen, J. J. Planta Med. 2006, 72, 951-954.
21. Yan, M. H.; Cheng, P.; Jiang, Z. Y.; Ma, Y. B.; Zhang, X. M.; Zhang, F. X.; Yang, L. P.; Zheng, Y. T.; Chen, J. J. J. Nat. Prod. 2008, 71, 760-763.
22. Chen, P.; Ma, Y. B.; Yao, S. Y.; Zhang, Q.; Wang, E. J.; Yan, M. H.; Zhang, X. M.; Zhang, F. X.; Chen, J. J. Bioorg. Med. Chem. Lett. 2007, 17, 5316-5320.
23. Wu, Y. R.; Ma, Y. B.; Zhao, Y. X.; Yao, S. Y.; Zhou, J.; Zhou, Y.; Chen, J. J. Planta Med. 2007, 73, 787-791.
24. 6 caled 333.1338).
25. Bhaskar, H. B.; Haren, J. P. Chem. Ind. 1974, 5, 773-774.
26. 2 = 0.0912. The crystal structure of compound 1 was solved by direct method SHLXS97 (Sheldrick, 1990) and expanded using difference Fourier technique, refined by the program SHLXL-97 (Sheldrick, 1997) and the full-matrix least-squares calculations. Crystallographic data for compound 1 have been deposited in the Cambridge Crystallographic Data Centre (deposition no.: CCDC 732831). Copies of these data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving.htm (or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB21EZ, U.K.; fax: (+44) 1223-336-033; or deposit@ccdc.cam.ac.uk
27. 6Na caled 355.1157).
28. 2 = 0.0526. The crystal structure of 2 was solved by direct method SHLXS-97 (Sheldrick, 1990) and expanded using difference Fourier technique, refined by the program SHLXL-97 (Sheldrick, 1997) and the full-matrix leastsquares calculations. Crystallographic data for the structure of 2 have been deposited in the Cambridge Crystallographic Data Centre (deposition, number CCDC 737518). Copies of these data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/ retrieving. html (or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB21EZ, U.K.; fax: (+44) 1223-336-033; or desposit@ccdc.cam.ac. uk).
29. Lupberger, J.; Mund, A.; Kock, J.; Hildt, E.J. Hepatol. 2006, 45, 547-552.