Design and synthesis of novel 5-substituted acyclic pyrimidine nucleosides as potent and selective inhibitors of hepatitis B virus

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 2032-2040

  Kumar, Rakesh ^a   Nath, Mahendra ^a   Tyrrell, D Lorne J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 5 (1 AZIDOVINYL)URACIL; 1 [4 HYDROXY 3 (HYDROXYMETHYL) 1 BUTYL] 5 (1 AZIDOVINYL)URACIL; 1 [4 HYDROXY 3 (HYDROXYMETHYL) 1 BUTYL] 5 [2 (1 AZIRINYL)]URACIL; 1 [[2 HYDROXY 1 (HYDROXYMETHYL)ETHOXY]METHYL] 5 (1 AZIDOVINYL)URACIL; 1 [[2 HYDROXY 1 (HYDROXYMETHYL)ETHOXY]METHYL] 5 [2 (1 AZIRINYL)]URACIL; LAMIVUDINE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY TEST; DRUG DECOMPOSITION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NONHUMAN; T LYMPHOCYTE; VIRUS INHIBITION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL DIVISION; CELLS, CULTURED; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; DUCKS; HEPATITIS B VIRUS; HEPATITIS B VIRUS, DUCK; HEPATOCYTES; HUMANS; PYRIMIDINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 0037046581     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010410d     Document Type: Article

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