Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 95-100

  Arthuis, Martin ^a,b   Pontikis, Renée ^a,b   Chabot, Guy G ^c,d   Quentin, Lionel ^c,d   Scherman, Daniel ^c,d   Florent, Jean Claude ^a,b  

^a INSTITUT CURIE   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Centre National de la Recherche Scientifique   (France)

Author keywords

Aroylindole; Combretastatin; Cytotoxicity; Phenstatin; Tubulin

Indexed keywords

(3 AMINO 4 METHYLPHENYL)(4,5,6 TRIMETHOXY 1H INDOL 2 YL)METHANONE; (3 AMINO 4 METHYLPHENYL)(5,6,7 TRIMETHOXY 1H INDOL 2 YL)METHANONE; (3 FLUORO 4 METHOXYPHENYL)(4,5,6 TRIMETHOXY 1H INDOL 2 YL)METHANONE; (3 FLUORO 4 METHOXYPHENYL)(5,6,7 TRIMETHOXY 1H INDOL 2 YL)METHANONE; (4,5,6 TRIMETHOXY 1H INDOL 2 YL)(4 METHOXYPHENYL)METHANONE; (4,5,6 TRIMETHOXY 1H INDOL 2 YL)(4 TOLYL)METHANONE; (4,5,6 TRIMETHOXY 1H INDOL 2 YL)(6 METHOXYPYRIDIN 3 YL)METHANONE; (5,6,7 TRIMETHOXY 1H INDOL 2 YL)(4 METHOXYPHENYL)METHANONE; (5,6,7 TRIMETHOXY 1H INDOL 2 YL)(4 TOLYL)METHANONE; (5,6,7 TRIMETHOXY 1H INDOL 2 YL)(6 METHOXYPYRIDIN 3 YL)METHANONE; (5,6,7 TRIMETHOXY 1H INDOL 2 YL)(PHENYL)METHANONE; 1 (4,5,6 TRIMETHOXY 1H INDOL 2 YL) 3 PHENYLPROP 2 EN 1 ONE; 1 (5,6,7 TRIMETHOXY 1H INDOL 2 YL) 3 PHENYLPROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; COMBRETASTATIN A4; PALLADIUM; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; CELL GROWTH; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN POLYMERIZATION; SUBSTITUTION REACTION;

EID: 78650513453     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.10.018     Document Type: Article

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