(E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea inhibits proliferation of MCF-7 cells through G1 cell cycle arrest and mitochondria-mediated apoptosis

Molecules and Cells

Volumn 30, Issue 4, 2010, Pages 303-310

  Yu, Ji Yeon ^a   Kim, Ji Hae ^a   Kim, Tae Geum ^a   Kim, Beom Tae ^a   Jang, Yong Suk ^a   Lee, Jeong Chae ^a  

^a Chonbuk National University   (South Korea)

Author keywords

caspase; G1 cell cycle arrest; MCF 7 breast cancer cells; mitochondria; phenethyl urea derivative

Indexed keywords

1 (3,4 DIHYDROXYPHENETHYL) 3 STYRYLUREA; ANTIOXIDANT; CASPASE 9; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER PREVENTION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MELANOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN INDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, DUCTAL, BREAST; CASPASES; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYTOCHROMES C; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UREA;

EID: 78650511747     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-010-0119-7     Document Type: Article

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