Brain regional α-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder

American Journal of Psychiatry

Volumn 158, Issue 5, 2001, Pages 775-782

  Leyton, Marco ^b   Okazawa, Hidehiko ^b   Diksic, Mirko ^b   Paris, Joel ^b   Rosa, Pedro ^b   Mzengeza, Shadreck ^b   Young, Simon N ^b   Blier, Pierre ^b   Benkelfat, Chawki ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; N METHYLTRYPTOPHAN; SEROTONIN 1 RECEPTOR;

ADULT; ARTICLE; BORDERLINE STATE; BRAIN MAPPING; BRAIN REGION; CINGULATE GYRUS; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FRONTAL CORTEX; HORMONE SYNTHESIS; HUMAN; IMPULSIVENESS; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; TEMPORAL CORTEX;

ADULT; BORDERLINE PERSONALITY DISORDER; BRAIN; CARBON RADIOISOTOPES; CEREBRAL CORTEX; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; MAGNETIC RESONANCE IMAGING; MALE; SEROTONIN; SEX FACTORS; TOMOGRAPHY, EMISSION-COMPUTED; TRYPTOPHAN;

EID: 0035024978     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.158.5.775     Document Type: Article

References (36)

1. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK: Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 1982; 139: 741-746
2. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK: Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 1983; 33:2609-2614
3. Åsberg M: Neurotransmitters and suicidal behavior: the evidence from cerebrospinal fluid studies. Ann NY Acad Sci 1997; 836:158-181
4. Coccaro EF: Central serotonin and impulsive aggression. Br J Psychiatry 1989; 155(suppl 8):52-62
5. Coccaro EF, Kavoussi RJ, Sheline YI, Lish JD, Csernansky JG: Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry 1996; 53:531-536
6. Mann JJ, McBride PA, Anderson GM, Mieczkowski TA: Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology. Biol Psychiatry 1992; 32:243-257
7. LeMarquand DG, Benkelfat C, Pihl RO, Palmour RM, Young SN: Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism. Am J Psychiatry 1999; 156:1771-1779
8. Cleare AJ, Bond AJ: The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology (Berl) 1995; 118:72-81
9. Moeller FG, Dougherty DM, Swann AC, Collins D, Davis CM, Cherek DR: Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology (Berl) 1996; 126:97-103
10. Diksic M, Nagahiro S, Sourkes TL, Yamamoto YL: A new method to measure brain serotonin synthesis in vivo, I: theory and basic data for a biological model. J Cereb Blood Flow Metab 1990; 10:1-12
11. Cohen Z, Tsuiki K, Takada A, Beaudet A, Diksic M, Hamel E: In vivo-synthesized radioactively labelled α-methyl serotonin as a selective tracer for visualization of brain serotonin neurons. Synapse 1995; 21:21-28
12. 11C]Methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cereb Blood Flow Metab 2000; 20:2-9
13. Zanarini MC, Gunderson JG, Frankenburg FR, Chauncey DL: The revised Diagnostic Interview for Borderlines: discriminating BPD from other axis II disorders. J Personal Disord 1989; 3: 10-18
14. LeMarquand DG, Pihl RO, Young SN, Tremblay RE, Séguin JR, Palmour RM, Benkelfat C: Tryptophan depletion, executive functions, and disinhibition in aggressive, adolescent males. Neuropsychopharmacology 1998; 19:333-341
15. Leyton M, Young SN, Paris J, Pihl RO, Benkelfat C: Suicide attempts and impulsivity (abstract). Biol Psychiatry 1999; 45(suppl8):146S
16. 11C]methyl-L-tryptophan for PET studies. Nucl Med Biol 1995; 22:303-307
17. Collins DL, Neelin P, Peter TM, Evans AC: Automatic 3D inter-subject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 1994; 18:192-205
18. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain. New York, Thieme Medical, 1988
19. 11C]methyl-tryptophan. J Cereb Blood Flow Metab 1998; 18:1121-1129
20. Patlak CS, Blasberg RG, Fenstermacher JD: Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983; 3:1-7
21. Okazawa H, Diksic M: Image generation of the serotonin synthesis rate using α-methyl-tryptophan and PET. J Comput Assist Tomogr 1998; 22:777-785
22. Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RSJ: The relationship between global and local changes in PET studies. J Cereb Blood Flow Metab 1990; 10: 458-466
23. 11C]methyl-L-tryptophan. J Psychiatry Neurosci 2000; 25:359-370
24. Goyer PF, Andreason PJ, Semple WE, Clayton AH, King AC, Compton-Toth BA, Schulz SC, Cohen RM: Positron-emission tomography and personality disorders. Neuropsychopharmacology 1994; 10:21-28
25. Kuruoglu AC, Arikan Z, Vural G, Karatas M, Arac M, Isik E: Single photon emission computerized tomography in chronic alcoholism: antisocial personality disorder may be associated with decreased frontal perfusion. Br J Psychiatry 1996; 169:348-354
26. 18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology 1999; 20:413-423
27. 11C]α-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations. Neuropsychopharmacology 1998; 19:345-353
28. 14C] labeled tracer. J Cereb Blood Flow Metab 2000; 20:244-252
29. Gharib A, Balende C, Sarda N, Weissmann D, Plenevaux A, Luxen A, Bobillier P, Pujol JF: Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the alpha-methyl-L-tryptophan method. J Neurochem 1999; 72:2593-2600
30. 11C]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain. Neuropsychopharmacology 1999; 21:153-157
31. Diksic M, Leyton M, Benkelfat C: Is alpha-methyl-L-tryptophan a good tracer for brain serotonin synthesis measurements, and does the lumped constant vary in different structures of the rat brain? J Neurochem 1999; 73:2621-2624
32. 14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp. Neurochem Res 2000; 25: 1537-1546
33. Takada A, Grdisa M, Gjedde A, Yamamoto YL: Rapid steady-state analysis of blood-brain transfer of L-Trp in rat, with special reference to the plasma protein binding. Neurochem Int 1983; 23:351-359
34. Fenstermacher JD, Blasberg RG, Patlak C: Methods for quantifying the transport of drugs across brain barrier systems. Pharmacol Ther 1981; 14:P217-P248
35. Rosa P, Diksic M, Okazawa H, Debonnel G, Blier P, Mzengeza S, Kapczinski F, Leyton M, Benkelfat C: Rates of brain 5-HT synthesis in patients with major depression, in Abstracts of Panels and Posters, 38th Annual Meeting of the American College of Neuropsychopharmacology. Nashville, ACNP, 1999, p 261
36. Siever LJ, Davis KL: A psychobiological perspective on the personality disorders. Am J Psychiatry 1991; 148:1647-1658