Enhanced hypocholesterolemic effects of interesterified oils are mediated by upregulating ldl receptor and cholesterol 7-α- Hydroxylase gene expression in rats1-3

Journal of Nutrition

Volumn 141, Issue 1, 2011, Pages 24-30

  Reena, Malongil B ^a   Gowda, Lalitha R ^b   Lokesh, Belur R ^a  

^a Department of Lipid Science and Traditional Foods ^*  (India)

^b CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL 7ALPHA MONOOXYGENASE; COCONUT OIL; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERESTERIFIED OIL; LOW DENSITY LIPOPROTEIN RECEPTOR; OIL; SESAME SEED OIL; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FAT INTAKE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEOSTASIS; HYPERCHOLESTEROLEMIA; INTERESTERIFICATION; MALE; NONHUMAN; RAT; RECEPTOR GENE; RICE BRAN;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; FATTY ACIDS; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MALE; PLANT OILS; RATS; RATS, WISTAR; RECEPTORS, LDL; SESAME OIL; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

RATTUS; SESAMUM INDICUM;

EID: 78650491021     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.127027     Document Type: Article

References (40)

1. Hunter JE, Zhang J, Kris-Etherton PM. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: A systematic review. Am J Clin Nutr. 2010;91:46-63.
2. Shimada K, Mokuno H, Matsunaga E, Miyazaki T, Sumiyoshi K, Miyauchi K, Daida H. Circulating oxidized low-density lipoprotein is an independent predictor for cardiac event in patients with coronary artery disease. Atherosclerosis. 2004;174:343-7.
3. Cantwell MM. Assessment of individual fatty acid intake. Proc Nutr Soc. 2000;59:187-91.
4. Hegsted DM, Ausman LM, Johnson JA, Dallal GE. Dietary fat and serum lipids: An evaluation of the experimental data. Am J Clin Nutr. 1993;57:875-83.
5. Scislowski V, Bauchart D, Gruffat D, Laplaud P, Durand D. Effect of dietary n-6 and n-3 polyunsaturated fatty acids on peroxidizability of lipoproteins in steers. Lipids. 2005;40:1245-56.
6. Ghafoorunissa. Requirements of dietary fats to meet nutritional needs and prevent the risk of atherosclerosis-an Indian perspective. Indian J Med Res. 1998;108:191-202.
7. Fogli-Cawley JJ, Dwyer JT, Saltzman E, McCullough M, Troy LM, Jacques PE. The 2005 dietary guidelines for Americans adherence index: Development and application. J Nutr. 2006;136:2908-15.
8. Kennedy JP. Structured lipids: Fats of the future. Food Technol. 1991; 44:76-83.
9. Rodriguez JN, Gioielli LA. Chemical interesterification of milkfat and milkfat-corn oil blends. Food Res Int. 2003;36:149-59.
10. Reena MB, Reddy YRS, Lokesh BR. Changes in triglyceride molecular species and thermal properties of blended and interesterified mixtures of coconut oil with rice bran oil or sesame oil, and palm oil with rice bran oil or sesame oil. Eur J Lipid Sci Technol. 2009;111:346-57.
11. Ronne TH, Yang T, Mu H, Jacobsen C, Xu X. Enzymatic interesterification of butterfat with rapeseed oil in a continuous packed bed reactor. J Agric Food Chem. 2005;53:5617-24.
12. Reena MB, Lokesh BR. Hypolipidemic effect of oils with balanced amounts of fatty acids obtained by blending and interesterification of coconut oil with rice bran oil or sesame oil. J Agric Food Chem. 2007; 55:10461-9.
13. Nagaraju A, Lokesh BR. Interesterified coconut oil blends with groundnut oil or olive oil exhibit greater hypocholesterolemic effect compared with their respective physical blends in rats. Nutr Res. 2007; 27:580-6.
14. Matsuyama H, Sato K, Nakamura Y, Suzuki K, Akiba Y. Modulation of regulatory factors involved in cholesterol metabolism in response to feeding of pravastatin- or cholesterol-supplemented diet in chickens. Biochim Biophysic Acta 2005;1734:136-42.
15. Cheema SK, Cikaluk D, Agellon LB. Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol 7-a-hydroxylase gene expression. J Lipid Res. 1997;38:315-23.
16. Rudling M. Hepatic mRNA levels for the LDL receptor and HMG CoA reductase show coordinate regulation in vivo. J Lipid Res. 1992;33: 493-501.
17. Miserez AR, Muller PY, Barella L, Barella S, Staehelin HB, Leitersdorf E, Kark JD, Friedlander Y. Sterol regulatory element binding protein (SREBP-2) contributes to polygenic hypercholesterolemia. Atherosclerosis. 2002;164:15-26.
18. Sato R, Miyamoto W, Inoue J, Terada T, Imanaka T, Maeda M. Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. J Biol Chem. 1999;274: 24714-20.
19. Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr. 2005;25:317-40.
20. Morrison WR, Smith LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron trifluoride-methanol. J Lipid Res. 1964;5:600-8.
21. AIN. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr. 1977;107:1340-8.
22. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-7.
23. Searcy RL, Bergquist LM. A new color reaction for the quantitation of serum cholesterol. Clin Chim Acta. 1960;5:192-9.
24. Warnick GR, Albers JJ. A comprehensive evaluation of the heparinmanganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res. 1978;19:65-76.
25. Shapiro DJ, Rodwell VW. Regulation of hepatic 3-hydroxy 3- methyl glutaryl CoA and cholesterol synthesis. J Biol Chem. 1971;246:3210-6.
26. Hulcher FH, Oleson WH. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J Lipid Res. 1973;14:625-31.
27. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein estimation with folin phenol reagent. J Biol Chem. 1951;193:265-75.
28. Small DM. The effect of glyceride structure on absorption and metabolism. Annu Rev Nutr. 1991;11:413-34.
29. Rao R, Lokesh BR. Nutritional evaluation of structured lipid containing omega-6 fatty acid synthesized from coconut oil in rats. Mol Cell Biochem. 2003;248:25-33.
30. Kritchevsky D, Davidson LM, Weight M, Kriek NPJ, du Plessis JP. Influence of native and randomized peanut oil on lipid metabolism and aortic sudanophilia in vervet monkeys. Atherosclerosis. 1982;42:53-8.
31. Kritchevsky D, Tepper SA. Cholesterol vehicle in experimental atherosclerosis XV. Randomized butter and randomized lard. Atherosclerosis. 1977;27:339-45.
32. Christophie A, Matthys F, Geers R, Veronk G. Nutritional studies with randomized butter. Cholesterolemic effect of butter oil and randomized butter oil. Arch Int Physiol Biochim. 1978;86:413-5.
33. Straarup EM, Hoy C. Structured lipids improve fat absorption in normal and malabsorbing rats. J Nutr. 2000;130:2802-8.
34. Kasai M, Nosaka N, Maki H, Negishi S, Aoyama T, Nakamura M, Suzuki Y, Tsuji H, Uto H, et al. Effect of dietary medium- and longchain triacylglycerols (MLCT) on accumulation of body fat in healthy humans. Asia Pac J Clin Nutr. 2003;12:151-60.
35. Dorfman SE, Lichtenstein AH. Dietary fatty acids differentially modulate messenger RNA abundance of low-density lipoprotein receptor, 3-hydroxy- 3-methylglutaryl coenzyme A reductase, and microsomal triglyceride transfer protein in Golden-Syrian hamsters. Metabolism. 2006;55:635-41.
36. Bennett AJ, Billett MA, Salter AM, Mangiapane EH, Bruce JS, Anderton KL, Marenah CB, Lawson N, White DA. Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Comparison of trimyristin, tripalmitin, tristearin and triolein. Biochem J. 1995;311:167-73.
37. Horton JD, Jennifer A, Cuthbert JA, Spady DK. Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels. J Clin Invest. 1993;92:743-9.
38. Chen CW, Cheng HH. Rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr. 2006; 136:1472-6.
39. Lim JS, Adachi Y, Takahashi Y, Ide T. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007;97:85-95.
40. Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S, Yamada H. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res. 1991;32:629-38.