Hepatic and cardiac iron overload among patients with end-stage liver disease referred for liver transplantation

Clinical Transplantation

Volumn 24, Issue 5, 2010, Pages 643-651

  O'Glasser, Avital Y ^a   Scott, David L ^a   Corless, Christopher L ^a   Zaman, Atif ^a   Sasaki, Anna ^a   Gopal, Deepak V ^b   Rayhill, Stephen C ^a   Orloff, Susan L ^a   Ham, John M ^a   Rabkin, John M ^c   Flora, Ken ^d   Davies, Crispin H ^a   Broberg, Craig S ^a   Schwartz, Jonathan M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^d Oregon Clinic   (United States)

Author keywords

Hemochromatosis; Hemosiderosis; Liver transplantation

Indexed keywords

FERRITIN; TRANSFERRIN;

ADULT; AGED; ARTICLE; CARDIOTOXICITY; CLINICAL EVALUATION; CONTROLLED STUDY; END STAGE LIVER DISEASE; FEMALE; HUMAN; IRON OVERLOAD; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; CARDIOMYOPATHIES; COHORT STUDIES; END STAGE LIVER DISEASE; FEMALE; FERRITINS; GENOTYPE; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON OVERLOAD; LIVER TRANSPLANTATION; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; YOUNG ADULT;

EID: 78650444967     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01136.x     Document Type: Article

References (39)

1. Saab S, Han SH, Martin P. Liver transplantation. Selection, listing criteria, and preoperative management. Clin Liver Dis 2000: 4: 513.
2. Murray KF, Carithers RJ. AASLD Practice guidelines: evaluation of the patient for liver transplantation. Hepatology 2005: 41: 1.
3. Kowdley KV, Hassanein T, Kaur S et al. Primary liver cancer and survival in patients undergoing liver transplantation for hemochromatosis. Liver Transpl Surg 1995: 1: 237.
4. Brandhagen DJ, Alvarez W, Therneau TM et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 2000: 31: 456.
5. Kilpe VE, Krakauer H, Wren RE. An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993: 56: 554.
6. Farrell FJ, Nguyen M, Woodley S et al. Outcome of liver transplantation in patients with hemochromatosis. Hepatology 1994: 20: 404.
7. Tung BY, Farrell FJ, Mccashland TM et al. Long-term follow-up after liver transplantation in patients with hepatic iron overload. Liver Transpl Surg 1999: 5: 369.
8. Brandhagen DJ. Liver transplantation for hereditary hemochromatosis. Liver Transpl 2001: 7: 663.
9. Crawford DH, Fletcher LM, Hubscher SG et al. Patient and graft survival after liver transplantation for hereditary hemochromatosis: implications for pathogenesis. Hepatology 2004: 39: 1655.
10. Kowdley KV, Brandhagen DJ, Gish RG et al. Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry. Gastroenterology 2005: 129: 494.
11. Limdi JK, Crampton JR. Hereditary haemochromatosis. QJM 2004: 97: 315.
12. Yu L, Ioannou GN. Survival of liver transplant recipients with hemochromatosis in the United States. Gastroenterology 2007: 133: 489.
13. Cotler SJ, Bronner MP, Press RD et al. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index. J Hepatol 1998: 29: 257.
14. Eng SC, Taylor SL, Reyes V, Raaka S, Berger J, Kowdley KV. Hepatic iron overload in alcoholic end-stage liver disease is associated with iron deposition in other organs in the absence of HFE-1 hemochromatosis. Liver Int 2005: 25: 513.
15. Ayonrinde OT, Olynyk JK. Clinical expression of hemochromatosis gene (HFE) variants. Hepatology 2007: 46: 960.
16. Ludwig J, Hashimoto E, Porayko MK, Moyer TP, Baldus WP. Hemosiderosis in cirrhosis: a study of 447 native livers. Gastroenterology 1997: 112: 882.
17. Harrison-Findik DD. Role of alcohol in the regulation of iron metabolism. World J Gastroenterol 2007: 13: 4925.
18. Valenti L, Pulixi EA, Arosio P et al. Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica 2007: 92: 1037.
19. Deugnier Y, Turlin B. Pathology of hepatic iron overload. World J Gastroenterol 2007: 13: 4755.
20. Sebastiani G, Walker AP. HFE gene in primary and secondary hepatic iron overload. World J Gastroenterol 2007: 13: 4673.
21. Tung BY, Emond MJ, Bronner MP, Raaka SD, Cotler SJ, Kowdley KV. Hepatitis C, iron status, and disease severity: relationship with HFE mutations. Gastroenterology 2003: 124: 318.
22. Harrison-Findik DD, Schafer D, Klein E et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006: 281: 22974.
23. Bridle K, Cheung TK, Murphy T et al. Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res 2006: 30: 106.
24. McFerson and Pinkus. Henry's Clinical Diagnosis and Management by Laboratory Methods, 21st edn. St. Louis, MO: W.B. Saunders Company, 2006.
25. Searle J, Kerr JRF, Halliday JW et al. Iron storage disease. In: MacSween RNM, Anthony PP, Scheuer PJ, eds. Pathology of the Liver. London: Churchill Livingstone, 1994: 219.
26. Libby P. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 8th edn. St. Louis, MO: W.B. Saunders Company. An Imprint of Elsevier, 2007.
27. Kowdley KV, Brandhagen DJ, Gish RG et al. Survival after orthotopic liver transplant (OLT) among patients with hepatic iron overload: interim results for the National Hemochromatosis Transplant Registry (NHTR). Hepatology 2001: 34: 236A. Presented at the annual meeting of the American Association for the Study of Liver Diseases, November 2001
28. Mandelli C, Cesarini L, Piperno A et al. Saturability of hepatic iron deposits in genetic hemochromatosis. Hepatology 1992: 16: 956.
29. Niederau C, Fischer R, Pürschel A, Stremmel W, Häussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996: 110: 1107.
30. Tavill AS; American Association for the Study of Liver Diseases; American College of Gastroenterology; American Gastroenterological Association. Diagnosis and management of hemochromatosis. Hepatology 2001: 33: 1321.
31. Garlitz BA, Harris EL, Beil TL, Smith TR. Screening for hereditary hemochromatosis: a systematic review for the US preventative task force. Ann Intern Med 2006: 145: 209.
32. Morrison ED, Brandhagen DJ, Phatak PD et al. Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenotypic hemochromatosis. Ann Intern Med 2003: 138: 627.
33. Adams PC, Barton JC. Haemochromatosis. Lancet 2007: 370: 1855.
34. Andrews NC, Schimdt PJ. Iron homeostasis. Annu Rev Physiol 2007: 69: 69.
35. Pietrangelo A. Hemochromatosis: an endocrine liver disease. Hepatology 2007: 46: 1291.
36. Fujita N, Sugimoto R, Takeo M et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007: 13: 97.
37. Nagashima M, Kudo M, Chung H et al. Regulatory failure of serum prohepcidin levels in patients with hepatitis C. Hepatol Res. 2006: 36: 288.
38. Nishina S, Hino K, Korenaga M et al. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology. 2008: 134: 226.
39. Demant AW, Schmiedel A, Büttner R, Lewalter T, Reichel C. Heart failure and malignant ventricular tachyarrhythmias due to hereditary hemochromatosis with iron overload cardiomyopathy. Clin Res Cardiol 2007: 96: 900.