Serum Ferritin Level Predicts Advanced Hepatic Fibrosis among U.S. Patients with Phenotypic Hemochromatosis

Annals of Internal Medicine

Volumn 138, Issue 8, 2003, Pages

  Morrison, Elizabeth D ^b   Brandhagen, David J ^b   Phatak, Pradyumna D ^b   Barton, James C ^b   Krawitt, Edward L ^b   El Serag, Hashem B ^b   Gordon, Stuart C ^b   Galan, Mark V ^b   Tung, Bruce Y ^b   Ioannou, George N ^b   Kowdley, Kris V ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FERRITIN; IRON; TRANSFERRIN;

ADULT; ARTICLE; FEMALE; GENE; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; UNITED STATES; AGE; BIOPSY; BLOOD; CLINICAL TRIAL; CROSS-SECTIONAL STUDY; ENZYMOLOGY; HOMOZYGOTE; LIVER; LIVER FUNCTION TEST; MIDDLE AGED; MULTICENTER STUDY; MUTATION; PATHOLOGY; PHENOTYPE; REGRESSION ANALYSIS; ROC CURVE; STATISTICAL MODEL;

ADULT; AGE FACTORS; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BIOPSY; CROSS-SECTIONAL STUDIES; FERRITINS; HEMOCHROMATOSIS; HOMOZYGOTE; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; LOGISTIC MODELS; MIDDLE AGED; MUTATION; PHENOTYPE; REGRESSION ANALYSIS; ROC CURVE; UNITED STATES;

EID: 1642494711     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-138-8-200304150-00008     Document Type: Article

References (12)

1. Edwards CQ, Griffen LM, Goldgar D, Drummond C, Skolnick MH, Kushner JP. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med. 1988;318:1355-62. [PMID: 3367936]
2. Adams PC, Speechley M, Kertesz AE. Long-term survival analysis in hereditary hemochromatosis. Gastroenterology. 1991;101:368-72. [PMID: 2065912]
3. Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G. Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med. 1985;313:1256-62. [PMID: 4058506]
4. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408. [PMID: 8696333]
5. Guyader D, Jacquelinet C, Moirand R, Turlin B, Mendler MH, Chaperon J, et al. Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis. Gastroenterology. 1998;115:929-36. [PMID: 9753496]
6. Bacon BR, Olynyk JK, Brunt EM, Britton RS, Wolff RK. HFE genotype in patients with hemochromatosis and other liver diseases. Ann Intern Med. 1999; 130:953-62. [PMID: 10383365]
7. Powell LW, George DK, McDonnell SM, Kowdley KV. Diagnosis of hemochromatosis. Ann Intern Med. 1998;129:925-31. [PMID: 9867744]
8. Tavill AS. Diagnosis and management of hemochromatosis. Hepatology. 2001;33:1321-8. [PMID: 11343262]
9. Kowdley KV, Trainer TD, Saltzman JR, Pedrosa M, Krawitt EL, Knox TA, et al. Utility of hepatic iron index in American patients with hereditary hemochromatosis: a multicenter study. Gastroenterology. 1997;113:1270-7. [PMID: 9322522]
10. Ludwig J, Batts KP, Moyer TP, Baldus WP, Fairbanks VF. Liver biopsy diagnosis of homozygous hemochromatosis: a diagnostic algorithm. Mayo Clin Proc. 1993;68:263-7. [PMID: 8474269]
11. Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology. 1986;6:24-9. [PMID: 3943787]
12. Beutler E, Felitti VJ, Koziol JA, Ho NJ, Gelbart T. Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet. 2002; 359:211-8. [PMID: 11812557]