Synthesis of N 4′ -[18F]fluoroalkylated ciprofloxacin as a potential bacterial infection imaging agent for PET study

Bioconjugate Chemistry

Volumn 21, Issue 12, 2010, Pages 2282-2288

  Sachin, Kalme ^a   Kim, Eun Mi ^a   Cheong, Su Jin ^a   Jeong, Hwan Jeong ^a   Lim, Seok Tae ^a   Sohn, Myung Hee ^a   Kim, Dong Wook ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); N4' 2 CHLOROETHYLCIPROFLOXACIN METHYL ESTER; N4' 2 FLUOROETHYLCIPROFLOXACIN; N4' 2 FLUOROETHYLCIPROFLOXACIN METHYL ESTER; N4' 2 HYDROXYETHYLCIPROFLOXACIN; N4' 2 HYDROXYETHYLCIPROFLOXACIN METHYL ESTER; N4' 3 FLUOROALKYLATED CIPROFLOXACIN F 18; N4' 3 FLUOROPROPYLCIPROFLOXACIN METHYL ESTER; N4' 3 HYDROXYPROPYLCIPROFLOXACIN; N4' 3 HYDROXYPROPYLCIPROFLOXACIN METHYL ESTER; N4' 3 METHANESULFONYLPROPYLCIPROFLOXACIN METHYL ESTER; N4' 4 HYDROXYBUTYLCIPROFLOXACIN; N4' 4 HYDROXYBUTYLCIPROFLOXACIN METHYL ESTER; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; CIPROFLOXACIN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIUM DETECTION; BINDING AFFINITY; CLINICAL EVALUATION; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; STRUCTURE ACTIVITY RELATION; ALKYLATION; ANIMAL; BINDING COMPETITION; BLOOD; CHEMISTRY; DIAGNOSTIC IMAGING; DRUG ANTAGONISM; DRUG EFFECT; DRUG STABILITY; GROWTH, DEVELOPMENT AND AGING; HALOGENATION; HUMAN; METABOLISM; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; RAT; SPRAGUE DAWLEY RAT; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

BACTERIA (MICROORGANISMS);

ALKYLATION; ANIMALS; BACTERIAL INFECTIONS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CIPROFLOXACIN; DIAGNOSTIC IMAGING; DNA GYRASE; DRUG STABILITY; ESCHERICHIA COLI; FLUORINE RADIOISOTOPES; HALOGENATION; HUMANS; ISOTOPE LABELING; MICROBIAL SENSITIVITY TESTS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78650334616     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc1002983     Document Type: Article

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