Inability of 99mTc-ciprofloxacin scintigraphy to discriminate between septic and sterile osteoarticular diseases

Journal of Nuclear Medicine

Volumn 44, Issue 6, 2003, Pages 920-926

  Sarda, Laure ^a,b   Crémieux, Anne Claude ^b   Lebellec, Yves ^b   Meulemans, Alain ^b   Lebtahi, Rachida ^b   Hayem, Gilles ^b   Génin, Rémi ^b   Delahaye, Nicolas ^b   Huten, Denis ^b   Le Guludec, Dominique ^b  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b BICHAT HOSPITAL   (France)

Author keywords

Infection; Osteoarticular disease; Radiolabeled ciprofloxacin

Indexed keywords

CIPROFLOXACIN TC 99M; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; CIPROFLOXACIN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; TECHNETIUM COMPLEX; TECHNETIUM TC 99M CIPROFLOXACIN;

ARTICLE; BACTERIAL ARTHRITIS; BIOPSY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DRUG BINDING; HISTOLOGY; HUMAN; ISOTOPE LABELING; OSTEOARTHROPATHY; PRIORITY JOURNAL; RADIODIAGNOSIS; SCINTIGRAPHY; ADULT; AGED; ARTHROPATHY; BONE DISEASE; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; INFECTIOUS ARTHRITIS; LABORATORY DIAGNOSIS; MALE; MIDDLE AGED; OSTEOMYELITIS; PATHOLOGY; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; ARTHRITIS, INFECTIOUS; BONE DISEASES; CIPROFLOXACIN; DIAGNOSIS, DIFFERENTIAL; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; JOINT DISEASES; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; OSTEOMYELITIS; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0038162341     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Pandey R, Berendt AR, Athanasou NA, et al. Histological and microbiological findings in non-infected and infected revision arthroplasty tissues. The OSIRIS Collaborative Study Group. Arch Orthop Trauma Surg 2000;120:570-574
2. Garvin KL, Hanssen AD. Infection after total hip arthroplasty: past, present and future. J Bone Joint Surg Am. 1995;77:1576-1588.
3. Jackson WO, Schmalzried TP. Limited role of direct exchange arthroplasty in the treatment of infected hip replacements. Clin Orthop. 2000;381:101-105.
4. Fehring TK, Cohen B. Aspiration as a guide to sepsis in revision total hip arthroplasty. J Arthroplasty. 1996;11:543-547.
5. Welling MM, Paulusma-Annema A, Balter HS, Pauwels EKJ, Nibbering PH Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med. 2000;27:292-301.
6. Fournier B, Zhao X, Lu T, Drlica K, Hooper DC Selective targeting of topoisomerase IV and DNA gyrase in Staphylococcus aureus: different patterns of quinolone-induced inhibition of DNA synthesis. Antimicrob Agents Chemother 2000;44:2160-2165
7. Solanki KK, Bomanji J, Siraj Q, Small M, Britton KE. Tc99m "Infecton": a new class of radiopharmaceutical for imaging infection [abstract]. J Nucl Med. 1993, 34(supp]):119P.
8. 99mTc Infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection. Lancet 1996;347:233-235.
9. Britton KE, Vinjamuri S, Hall AV, et al. Clinical evaluation of technetium 99m Infecton for the localization of bacterial infection. Eur J Nucl Med. 1997;24: 553-556.
10. 99mTc-Infecton, a novel agent for detecting sites of infection. J Clin Pathol. 1998;51:215-219.
11. 99mTc-HMPAO leukocyte scintigraphy. J Nucl Med. 2001;42:567-574.
12. Yapar Z, Kibar M, Yapar AF, Togrul E, Kayaselçuk U, Sarpel Y The efficacy of technetium-99m ciprofioxacin (Infecton) imaging in suspected orthopaedic infection a comparison with sequential bone/gallium imaging. Eur J Nucl Med. 2001;28:822-830.
13. 99mTc-ciprofloxacin (Infecton) imaging in the diagnosis of knee prosthesis infections. Nucl Med Commun. 2002; 23:167-170.
14. Dumarey N, Blocklet D, Appelboom T, Tant L, Schoutens A. Infecton is not specific for bacterial osteo-articular infective pathology. Eur J Nucl Med 2002; 29:530-535.
15. 99mTc-labeled antimicrobial peptides for detection of bacterial and Candida albicans infections. J Nucl Med 2001;42: 788-794
16. 99mTc-ciprofloxaem scintigraphy in a rabbit model of Staphylococcus aureus prosthetic joint infection. J Nucl Med. 2002,43 239-245.
17. 99mTc-ciprofloxacin, a promising agent for the diagnosis of bacterial infection. Eur J Nucl Med. 2001;28:570-574.
18. Palestro CJ. The current role of gallium imaging in infection. Semin Nucl Med. 1994;XXIV 128-141
19. 99mTc nanocolloid scans in orthopaedics: a comparison with conventional bone scan. Nucl Med Commun. 1993;14:419-432
20. Schauwecker DS, Park HM, Mock BH, et al Evaluation of complicating osteomyelitis with Tc-99m MDP, In-111 granulocytes, and Ga-67 citrate. J Nucl Med 1984;25:849-853.
21. Pring DJ, Henderson RG, Keshavarzian A, et al. Indium-granulocyte scanning in the painful prosthetic joint. AJR 1986;147:167-172.
22. McCarthy K, Velchik MG, Alavi A, Mandell GA, Esterhai JL, Goll S. Indium-111-labeled white blood cells in the detection of osteomyelitis complicated by a pre-existing condition J Nucl Med. 1988;29:1015-1021
23. McCarthy K, Velchik MG, Alavi A, Mandell GA, Esterhai JL, Goll S. In-111-labeled leukocyte scintigraphy in suspected orthopedic prosthesis infection: comparison with other imaging modalities. Radiology. 1988;168:235-239.
24. El Esper I, Dacquet V, Paillard J, Bascoulergue G, Tahon MM, Fonroget J. 99Tcm-HMPAO-labelled leukocyte scintigraphy in suspected chronic osteomyelitis related to an orthopaedic device clinical usefulness. Nucl Med Commun. 1992;13:799-805.
25. Devillers A, Moisan A, Jean S, Arvieux C, Bourguet P. Technetium-99m hexamethylpropylene amine oxime leukocyte scintigraphy for the diagnosis of bone and joint infections: a retrospective study in 116 patients. Eur J Nucl Med. 1995;22:302-307.
26. Krznaric E, De Roo M, Verbruggen A, Stuyck J, Mortelmans L. Chronic osteomyelitis diagnosis with technetium-99m-d, I-hexamelhylpropylene amine oxime labelled leukocytes Eur J Nucl Med. 1996;23:792-797.
27. 99mTc-leukocyte scintigraphy in the diagnosis of post-stemotomy mediastinitis relapse [abstract]. J Nucl Med. 2001;42:45P.
28. Becker W, Bair J, Behr T, et al. Detection of soft-tissue infections and osteomyelitis using a technetium-99m labeled anti-granulocyte monoclonal antibody fragment. J Nucl Med. 1994;35:1436-1443.
29. Devillers A, Garin E, Polard JL, et al Comparison of Tc-99m-labelled antileukocyre fragment Fab' and Tc-99m HMPAO leukocyte scintigraphy in the diagnosis of bone and joint infections a prospective study. Nucl Med Commun. 2000;21:747-753.
30. 14C] sparfloxacin in experimental Staphylococcus aureus joint prosthesis infection. Antimicrob Agents Chemother 1996; 40:2111-2116.
31. Chun L, Yoon J, Song Y, Huie P, Regula D, Goodman S. The characterization of macrophages and ostcoclasts in tissue harvested from revised total hip prostheses. J Biomed Mater Res. 1999;48:899-903.
32. Walters JD, Nakkula RJ. Mechanisms of fluoroquinolone transport by human neutrophil. Antimicrob Agents Chemother 1999;43:2710-2715.
33. Bounds SJ, Nakkula R, Walters JD. Fluoroquinolone transport by human monocytes: characterization and comparison to other cells of myeloid lineage Antimicrob Agents Chemother. 2000;44:2609-2614.
34. Holtom PD, Pavkovic SA, Bravos PD, Patzakis MJ, Shepherd LE, Frenl B Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro. J Orthop Res. 2000;18:721-727.
35. Egerbacher M, Seiberl G, Wolfesberger B, Walter I Ciprofloxacin causes cytoskeletal changes and detachment of human and rat chondrocytes in vitro. Arch Toxicol. 2000;73:557-563.
36. Castora FJ, Vissering FF, Simpson MV The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria. Biochem Biophys Acta, 1983;740:417-427.
37. Williams RJ III, Attia E, Wieckiewicz TL, Hannafin JA. The effect of ciprofloxacin on tendon, paratendon, and capsular fibroblast metabolism. Am J Sports Med. 2000;28:364-369.
38. Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS, Bolander ME, Patel R Ciprofloxacin inhibition of experimental fracture-healing. J Bone Joint Surg. 2000;82:161-173.
39. Schlüter G. Ciprofloxacin: review of potential toxicologic effects. Am J Med. 1987;82(suppl 4A):91-93