Synthesis and antibacterial activity of 1-(2-fluorovinyl)-7-substituted-4- quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin

Journal of Medicinal Chemistry

Volumn 48, Issue 9, 2005, Pages 3194-3202

  Asahina, Yoshikazu ^a   Iwase, Kazuhiko ^a   Iinuma, Fujio ^a   Hosaka, Masaki ^a   Ishizaki, Takayoshi ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 FLUOROVINYL) 4 QUINOLONE 3 CARBOXYLIC ACID DERIVATIVE; 6 DIFLUORO 1 (2 FLUOROVINYL) 1,4 DIHYDRO 8 METHOXY 7 (4 METHYL 1 PIPERAZINYL) 4 OXO 3 QUINOLINECARBOXYLIC ACID; 6 FLUORO 1 (2 FLUOROVINYL) 1,4 DIHYDRO 7 (4 METHYL 1 PIPERAZINYL) 4 OXO 3 QUINOLINECARBOXYLIC ACID; 6,8 DIFLUORO 1 (2 FLUOROVINYL) 1,4 DIHYDRO 7 (4 METHYL 1 PIPERAZINYL) 4 OXO 3 QUINOLINECARBOXYLIC ACID; 7 (3 AMINO 1 PYRROLIDINYL) 6 FLUORO 1 (2 FLUOROVINYL) 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; 7 (3 AMINO 1 PYRROLIDINYL) 6 FLUORO 1 (2 FLUOROVINYL) 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINECARBOXYLIC ACID; 7 (3 AMINO 1 PYRROLIDINYL) 6,8 DIFLUORO 1 (2 FLUOROVINYL) 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); FLEROXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ISOMER;

ANTI-BACTERIAL AGENTS; CARBOXYLIC ACIDS; FLEROXACIN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244378266     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0402061     Document Type: Article

References (27)

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