Applications and degradation of proteins used as tissue engineering materials

Materials

Volumn 2, Issue 2, 2009, Pages 613-635

  Wang, Hua Jie ^a   Di, Ling ^a   Ren, Qiu Shi ^a   Wang, Jin Ye ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Biodegradation; Proteins; Tissue engineering

Indexed keywords

BIORESORBABILITY; BROAD APPLICATION; DRUG DELIVERY SYSTEM; ENGINEERING MATERIALS; SCAFFOLD FABRICATION; SILK FIBROIN;

BIOCOMPATIBILITY; BIODEGRADATION; BIOMECHANICS; DRUG DELIVERY; MECHANICAL PROPERTIES; MICROBIOLOGY; PROTEINS; TISSUE; TISSUE ENGINEERING; ZEIN;

SCAFFOLDS (BIOLOGY);

EID: 78650300459     PISSN: None     EISSN: 19961944     Source Type: Journal    
DOI: 10.3390/ma2020613     Document Type: Review

References (145)

1. Langer, R.; Vacanti, J.P. Tissue Engineering. Science 1993, 260, 920-926.
2. Laurencin, C.T.; Khan, Y.; Kofron, M.; El-Amin, S.; Botchwey, E.; Yu, X.; Cooper, J.A., Jr. The ABJS Nicolas andry award: tissue engineering of bone and ligament: a 15-year perspective. Clin. Orthop. Relat. Res. 2006, 447, 221-236.
3. Hunziker, E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr. Cartil. 2002, 10, 432-463. Materials 2009, 2 627
4. Wang, X.Y.; Kim, H.J.; Wong, C.; Vepari, C.; Matsumoto, A.; Kaplan, D.L. Fibrous proteins and tissue engineering. Mater. Today 2006, 9, 44-53.
5. Imen, E.H.; Nakamura, M.; Mie, M.; Kobatake, E. Construction of multifunctional proteins for tissue engineering: Epidermal growth factor with collagen binding and cell adhesive activities. J. Biotechnol. 2009, 139, 19-25.
6. Quaglia, F. Bioinspired tissue engineering: The great promise of protein delivery technologies. Int. J. Pharm. 2008, 364, 281-297.
7. Wang, X.Q.; Wenk, E.; Hu, X.; Castro, G.R.; Meinel, L.; Wang, X.Y.; Li, C.M.; Merkle, H.; Kaplan, D.L. Silk coating on PLGA and alginate microspheres for protein delivery. Biomaterials 2007, 28, 4161-4169.
8. Kottke-Marchant, K.; Anderson, J.M.; Umemura, Y.; Marchant, R.E. Effect of albumin coating on the in vitro blood compatibility of Dacron arterial prostheses. Biomaterials 1989, 10, 147-155.
9. Maltais, A.; Remondetto, G.E.; Subirade, M. Soy protein cold-hydrogels as controlled delivery devices for nutraceutical compounds. Food Hydrocolloids 2008, doi: 10.1016/j.foodhyd. Accessed December 6, 2008.
10. Ehrba, M.; Rizzi, S.C.; Hlushchuk, R.; Djonov, V.; Zisch, A.H.; Hubbell, J.A.; Weber, F.E.; Lutolf, M.P. Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. Biomaterials 2007, 28, 3856-3866.
11. Ju, Y.E.; Janmey, P.A.; McCormick, M.E.; Sawyer, E.S.; Flanagan, L.A. Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels. Biomaterials 2007, 28, 2097-2108.
12. Bootle-Wilbraham, C.A.; Tazzyman, S.; Thompson, W.D.; Stirk, C.M.; Lewis, S.F. Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro. Angiogenesis 2001, 4, 269-275.
13. Jegoux, F.; Goyenvalle, E.; Bagot D'arc, M.; Aguado, E.; Daculsi, G. In vivo biological performance of composites combing micro-macroporous biphasic calcium phosphate granules and fibrin sealant. Arch. Orthop. Trauma Surg. 2005, 125, 153-159.
14. Yamada, Y.; Boo, J.S.; Ozawa, R.; Nagasaka, T.; Okazaki, Y.; Hata, K.; Ueda, M. Bone regeneration following injection of mesenchymal stem cells and fibrin glue with a biodegradable scaffold. J. Craniomaxillofac. Surg. 2003, 31, 27-33.
15. Le Guehennec, I.; Goyenvalle, E.; Aguado, E.; Pilet, P.; Bagot D'Arc, M.; Bilban, M.; Spaethe, R.; Daculsi, G. MBCP biphasic calcium phosphate granules and tissucol fibrin sealant in rabbit femoral defects: the effect of fibrin on bone ingrowth. J. Mater. Sci.: Mater. Med. 2005, 16, 29-35.
16. Deutsch, M.; Meinhart, J.; Zilla, P.; Howanietz, N.; Gorlitzer, M.; Froeschl, A.; Stuempflen, A.; Bezuidenhout, D.; Grabenwoeger, M. Long-term experience in autologous in vitro endothelialization of infrainguinal ePTFE grafts. J. Vasc. Surg. 2009, 49, 352-362.
17. Willerth, S.M.; Arendas, K.J.; Gottlieb, D.I.; Sakiyama-Elbert, S.E. Optimization of fibrin scaffolds for differentiation of murine embryonic stem cells into neural lineage cells. Biomaterials 2006, 27, 5990-6003.
18. Eyrich, D.; Brandl, F.; Appel, B.; Wiese, H.; Maier, G.; Wenzel, M.; Staudenmaier, R.; Goepferich, A.; Blunk, T. Long-term stable fibrin gels for cartilage engineering. Biomaterials 2007, 28, 55-65. Materials 2009, 2 628
19. Zeugolis, D.I.; Khew, S.T.; Yew, E.S.Y.; Ekaputra, A.K.; Tong, Y.W.; Yung, L.Y.L.; Hutmacher, D.W.; Sheppard, C.; Raghunath, M. Electro-spinning of pure collagen nano-fibres- Just an expensive way to make gelatin? Biomaterials 2008, 29, 2293-2305.
20. Di LulloDagger, G.A.; Sweeney, S.M.; Körkkö, J.; Ala-Kokko, L.; Antonio, J.D.S. Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen. J. Biol. Chem. 2002, 277, 4223-4231.
21. Thumann, G.; Viethen, A.; Gaebler, A.; Walter, P.; Kaempf, S.; Johnen, S.; Salz, A. K. The in vitro and in vivo behaviour of retinal pigment epithelial cells cultured on ultrathin collagen membranes. Biomaterials 2009, 30, 287-294.
22. Hong, H.; McCullough, C. M.; Stegemann, J. P. The role of ERK signaling in protein hydrogel remodeling by vascular smooth muscle cells. Biomaterials 2007, 28, 3824-3833.
23. Lee, C.H.; Singla, A.; Lee, Y. Biomedical applications of collagen. Int. J. Pharm. 2001, 221, 1-22.
24. Li, S.T. Biologic biomaterials: tissue-derived biomaterials (collagen). In The biomedical engineering handbook; Bronzino, J.D., Eds.; CRC Press LLC: Boca Raton, FL, USA, 2000; pp. 627-647.
25. Dawson, J.I.; Wahl, D.A.; Lanham, S.A.; Kanczler, J.M.; Czernuszka, J.T.; Oreffo, R.O.C. Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells. Biomaterials 2008, 29, 3105-3116.
26. Wahl, D.A.; Czernuszka, J.T. Collagen-hydroxyapatite composites for hard tissue repair. Eur. Cell Mater. 2006, 11, 43-56.
27. Lai, H.M.; Geil, P.H.; Padua, G.W. X-ray diffraction characterization of the structure of zein-oleic acid films. J. Appl. Polym. Sci. 1999, 71, 1267-1281.
28. Shukla, R.; Cheryan, M. Zein: the industrial protein from corn. Ind. Crop. Prod. 2001, 13, 171-192.
29. Dong, J.; Sun, Q.S.; Wang, J.Y. Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility. Biomaterials 2004, 25, 4691-4697.
30. Wang, H.J.; Lin, Z.X.; Liu, X.M.; Sheng, S.Y.; Wang, J.Y. Heparin-loaded zein microsphere film and hemocompatibility. J. Control. Release 2005, 105, 120-131.
31. Liu, X.M.; Sun, Q.S.; Wang, H.J.; Zhang, L.; Wang, J.Y. Microspheres of corn protein, zein, for an ivermectin drug delivery system. Biomaterials 2005, 26,109-115.
32. Lawrence, B.D.; Marchant, J.K.; Pindrus, M.A.; Omenetto, F.G.; Kaplan, D.L. Silk film biomaterials for cornea tissue engineering. Biomaterials 2009, 30, 1299-1308.
33. Vepari, C.; Kaplan, D.L. Silk as a biomaterial. Prog. Polym. Sci. 2007, 32, 991-1007.
34. Fuchs, S.; Motta, A.; Migliaresi, C.; Kirkpatrick, C.J. Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells as a potential source of autologous cells for endothelialization of silk fibroin biomaterials. Biomaterials 2006, 27, 5399-5408.
35. Unger, R.E.; Wolf, M.; Peters, K.; Motta, A.; Migliaresi, C.; Kirkpatrick, C.J. Growth of human cells on a non-woven silk fibroin net: a potential for use in tissue engineering. Biomaterials 2004, 25, 1069-1075.
36. Kim, U.J.; Park, J.Y.; Kim, H.J.; Wada, M.; Kaplan, D.L. Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin. Biomaterials 2005, 26, 2775-2785. Materials 2009, 2 629
37. Kim, H.J.; Kim, U.J.; Vunjak-Novakovic, G.; Min, B.H.; Kaplan, D.L. Influence of macroporous protein scaffolds on bone tissue engineering from bone marrow stem cells. Biomaterials 2005, 26, 4442-4452.
38. Hofmann, S.; Hagenmuller, H.; Koch, A.M.; Muller, R.; Vunjak-Novakovic, G.; Kaplan, D.L.; Merkle, H.P.; Meinel, L. Control of in vitro tissue-engineered bone-like structure using human mesenchymal stem cells and porous silk scaffolds. Biomaterials 2007, 28, 1152-1162.
39. Wang, Y.Z.; Rudym, D.D.; Walsh, A.; Abrahamsen, L.; Kim, H.J.; Kim, H.S.; Kirker-Head, C.; Kaplan, D. In vivo degradation of three-dimensional silk fibroin scaffolds. Biomaterials 2008, 29, 3415-3428.
40. Bondar, B.; Fuchs, S.; Motta, A.; Migliaresi, C.; Kirkpatrick, C.J. Functionality of endothelial cells on silk fibroin nets: Comparative study of micro- and nanometric fibre size. Biomaterials 2008, 29, 561-572.
41. Wenk, E.; Wandrey, A.J.; Merkle, H.P.; Meinel, L. Silk fibroin spheres as a platform for controlled drug delivery. J. Control. Rel. 2008, 132, 26-34.
42. Hofmann, S.; Foo, C.T.; Rossetti, F.; Textor, M.; Vunjak-Novakovic, G.; Kaplan, D.L.; Merkle, H.P.; Meinel, L. Silk fibroin as an organic polymer for controlled drug delivery. J. Control. Release 2006, 111, 219-227.
43. Uebersax, L.; Mattotti, M.; Papaloizos, M.; Merkle, H.P.; Gander, B.; Meinel, L. Silk fibroin matrices for the controlled release of nerve growth factor (NGF). Biomaterials 2007, 28, 4449-4460.
44. Li, C.; Vepari, C.; Jin, H.J.; Kim, H.J.; Kaplan, D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 2006, 27, 3115-3124.
45. Uebersax, L.; Merkle, H.P.; Meinel, L. Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells. J. Control. Rel. 2007, 127, 12-21.
46. Demura, M.; Takekawa, T.; Asakura, T.; Nishikawa, A. Characterization of lowtemperature-plasma treated silk fibroin fabrics by ESCA and the use of the fabrics as an enzyme-immobilization support. Biomaterials 1992, 13, 276-280.
47. Kikuchi, J.; Mitsui, Y.; Asakura, T.; Hasuda, K.; Araki, H.; Owaku, K. Spectroscopic investigation of tertiary fold of staphylococcal protein A to explore its engineering application. Biomaterials 1999, 20, 647-654.
48. Katoh, K.; Tanabe, T.; Yamauchi, K. Novel approach to fabricate keratin sponge scaffolds with controlled pore size and porosity. Biomaterials 2004, 25, 4255-4262.
49. Tachibana, A.; Furuta, Y.; Takeshima, H.; Tanabe, T.; Yamauchi, K. Fabrication of wool keratin sponge scaffolds for long-term cell cultivation. J. Biotechnol. 2002, 93, 165-170.
50. Tachibana, A.; Nishikawa, Y.; Nishino, M.; Kaneko, S.; Tanabe, T.; Yamauchi, K. Modified keratin sponge: Binding bone morphogenetic protein-2 and osteoblast differentiation. J. Biosci. Bioeng. 2006, 102, 425-429.
51. Yamauchi, K.; Mniwa, M.; Mori, T. Cultivation of fibroblast cells on keratin-coated substrata. J. Biomater. Sci. Polym. Ed. 1998, 9, 259-270.
52. Katoh, K.; Shibayama, M.; Tanabe, T.; Yamauchi, K. Preparation and physicochemical properties of compression-molded keratin films. Biomaterials 2004, 25, 2265-2272. Materials 2009, 2 630
53. Sierpinski, P.; Garrett, J.; Ma, J.J.; Apel, P.; Klorig, D.; Smith, T.; Koman, L.A.; Atala, A.; Van Dyke, M. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves. Biomaterials 2008, 29, 118-128.
54. Apel, P.J.; Garrett, J.P.; Sierpinski, P.; Ma, J.J.; Atala, A.; Smith, T.L.; Koman, L.A.; Van Dyke, M. Peripheral nerve regeneration using a keratin-based scaffold: long-term functional and histological outcomes in a mouse model. J. Hand Surg. 2008, 33, 1541-1547.
55. Hamasaki, S.; Tachibana, A.; Tada, D.; Yamauchi, K.; Tanabe, T. Fabrication of highly porous keratin sponges by freeze-drying in the presence of calcium alginate beads. Mater. Sci. Eng. C 2008, 28, 1250-1254.
56. Somanathan, N.; Naresh, M.D.; Arumugam, V.; Sanjeevi, R. Mechanism of failure of hydrolyzed casein films. Eur. Polym. J. 2000, 36, 2485-2490.
57. Diak, O.A.; Bani-Jaber, A.; Amro, B.; Jones, D.; Andrews, G.P. The Manufacture and characterization of casein films as novel tablet coatings. Food Bioproduct. Proc. 2007, 85, 284-290.
58. Latha, M.S.; Rathinam, K.; Mohanan, P.V.; Jayakrishnan, A. Bioavailability of theophylline from glutaraldehyde cross-linked casein microspheres in rabbits following oral administration. J. Control. Rel. 1995, 34, 1-7.
59. Latha, M.S.; Lal, A.V.; Kumary, T.V.; Sreekumar, R.; Jayakrishnan, A. Progesterone release from glutaraldehyde cross-linked casein microspheres: in vitro studies and in vivo response in rabbits. Contraception 2000, 61, 329-334.
60. Rhodes, B.A.; Zolle, I.; Buchanan, J.W.; Wagner, H.N. Jr. Radioactive albumin microspheres for studies of the pulmonary circulation. Radiology 1969, 92, 1453-1460.
61. Zolle, I.; Rhodes, B.A.; Wagner, H.N., Jr. Preparation of metabolizable radioactive human serum albumin microspheres for studies of the circulation. Int. J. Appl. Radiat. Isot. 1970, 21, 155-167.
62. Iemma, F.; Spizzirri, U.G.; Puoci, F.; Muzzalupo, R.; Trombino, S.; Cassano, R.; Leta, S.; Picci, N. pH-sensitive hydrogels based on bovine serum albumin for oral drug delivery. Int. J. Pharm. 2006, 312, 151-157.
63. Gan, C.Y.; Cheng, L.H.; Phuah, E.T.; Chin, P.N.; Alkarkhi, A.F.M.; Easa, A.M. Combined cross-linking treatments of bovine serum albumin gel beadlets for controlled-delivery of caffeine. Food Hydrocolloids 2009, 23, 1398-1405.
64. Yamauchi, K.; Hojo, H.; Yamamoto, Y.; Tanabe, T. Enhanced cell adhesion on RGDS-carrying keratin film. Mater. Sci. Eng. C 2003, 23, 467-472.
65. Ruszczak, Z.; Friess, W. Collagen as a carrier for on-site delivery of antibacterial drugs. Adv. Drug Deliv. Rev. 2003, 55, 1679-1698.
66. Mandal, B.B.; Kapoor, S.; Kundu, S.C. Silk fibroin/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release. Biomaterials 2009, 30, 2826-2836.
67. Kellouche, S.; Martin, C.; Korb, G.; Rezzonico, R.; Bouard, D.; Benbunan, M.; Dubertret, L.; Soler, C.; Legrand, C.; Dosquet, C. Tissue engineering for full-thickness burns: A dermal substitute from bench to bedside. Biochem. Biophys. Res. Commun. 2007, 363, 472-478.
68. Fan, H.B.; Liu, H.F.; Wong, E.J.W.; Toh, S.L.; Goh, J.C.H. In vivo study of anterior cruciate ligament regeneration using mesenchymal stem cells and silk scaffold. Biomaterials 2008, 29, 3324-3337. Materials 2009, 2 631
69. Fang, Q.; Chen, D.L.; Yang, Z.M.; Li, M. In vitro and in vivo research on using antheraea pernyi silk fibroin as tissue engineering tendon scaffolds. Mat. Sci. Eng. C 2009, doi: 10.1016/j.msec.2008.12.007.
70. Fuchs, S.; Jiang, X.; Schmidt, H.; Dohle, E.; Ghanaati, S.; Orth, C.; Hofmann, A.; Motta, A.; Migliaresi, C.; Kirkpatrick, C.J. Dynamic processes involved in the pre-vascularization of silk fibroin constructs for bone regeneration using outgrowth endothelial cells. Biomaterials 2009, 30, 1329-1338.
71. Deutsch, M.; Meinhart, J.; Zilla, P.; Howanietz, N.; Gorlitzer, M.; Froeschl, A.; Stuempflen, A.; Bezuidenhout, D.; Grabenwoeger, M. Long-term experience in autologous in vitro endothelialization of infrainguinal ePTFE grafts. J. Vasc. Surg. 2009, 49, 352-362.
72. Levenberg, S.; Rouwkema, J.; Macdonald, M.; Garfein, E.S.; Kohane, D.S.; Darland, D.C.; Marini, R.; van Blitterswijk, C.A.; Mulligan, R.C.; D'Amore, P.A.; Langer, R. Engineering vascularized skeletal muscle tissue. Nat. Biotechnol. 2005, 23, 879-884.
73. Osathanon, T.; Linnes, M.L.; Rajachar, R.M.; Ratner, B.D.; Somerman, M.J.; Giachelli, C.M. Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering. Biomaterials 2008, 29, 4091-4099.
74. Roche, S.; Ronziere, M.C.; Herbage, D.; Freyria, A.M. Native and DPPA cross-linked collagen sponges seeded with fetal bovine epiphyseal chondrocytes used for cartilage tissue engineering. Biomaterials 2001, 22, 9-18.
75. Liu, C.Z.; Xia, Z.D.; Han, Z.W.; Hulley, P.A.; Triffitt, J.T.; Czernuszka, J.T. Novel 3D collagen scaffolds fabricated by indirect printing technique for tissue engineering. J. Biomed. Mater. Res. Part B Appl. Biomater. 2007, 85B, 519-528.
76. Mosesson, M.W. Fibrinogen and fibrin structure and functions. J. Thromb. Haemost. 2005, 3, 1894-1904.
77. Cox, S.; Cole, M.; Tawil, B. Behavior of human dermal fibroblasts in three-dimensional fibrin clots: dependence on fibrinogen and thrombin concentration. Tissue Eng. 2000, 10, 942-954.
78. Nihouannen, D.L.; Guehennec, L.L.; Rouillon, T.; Pilet, P.; Bilban, M.; Layrolle, P.; Daculsi, G. Micro-architecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering. Biomaterials 2006, 27, 2716-2722.
79. Cao, H.; Xu, S.Y. EDC/NHS-crosslinked type II collagen-chondroitin sulfate. J. Mater. Sci. Mater. Med. 2008, 19, 567-575.
80. Chan, B.P.; Hui, T.Y.; Chan, O.C. M.; So, K.F.; Lu, W.; Cheung, K.M.C.; Salomatina, E.; Yaroslavsky, A. Photochemical cross-linking for collagen-based scaffolds: A study on optical properties, mechanical properties, stability and hematocompatibility. Tissue Eng. 2007, 13, 73-85.
81. Stark, Y.; Suck, K.; Kasper, C.; Wieland, M.; van Griensven, M.; Scheper, T. Application of collagen matrices for cartilage tissue engineering. Exp. Toxicol. Pathol. 2006, 57, 305-311.
82. Al-Munajjed, A.A.; O'Brien, F.J. Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair. J. Mech. Behav. Biomed. Mater. 2009, 2, 138-146.
83. Gelinsky, M.; Welzel, P.B.; Simon, P.; Bernhardt, A.; Konig, U. Porous three-dimensional scaffolds made of mineralized collagen: Preparation and properties of a biomimetic nanocomposite materials for tissue engineering bone. Chem. Eng. J. 2008, 137, 84-96. Materials 2009, 2 632
84. Pek, Y.S.; Gao, S.J.; Mohamed Arshad, M.S.; Leck, K.J.; Ying, J.Y. Porous collagen-apatite nanocomposite foams as bone regeneration scaffolds. Biomaterials 2008, 29, 4300-4305.
85. Kim, H.W.; Song, J.H.; Kim, H.E. Nanofiber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration. Adv. Funct. Mater. 2005, 15, 1988-1994.
86. Gong, S.J.; Wang, H.J.; Sun, Q.S.; Xue, S.T.; Wang, J.Y. Mechanical properties and in vitro biocompatibility of porous zein scaffolds. Biomaterials 2006, 27, 3793-3799.
87. Hutmacher, D.W. Scaffold in tissue engineering bone and cartilage. Biomaterials 2000, 21, 2529-2543.
88. Wang, H.J.; Gong, S.J.; Lin, Z.X.; Fu, J.X.; Xue, S.T.; Huang, J.C.; Wang, J.Y. In vivo biocompatibility and mechanical properties of porous zein scaffolds. Biomaterials 2007, 28, 3952-3964.
89. Jiang, H.L.; Zhao, P.C.; Zhu, K.J. Fabrication and characterization of zein-based nanofibrous scaffolds by an electrospinning method. Macromol. Biosci. 2007, 7, 517-525.
90. Fini, M.; Motta, A.; Torricelli, P.; Giavaresi, G.; Nicoli Aldini, N.; Tschon, M.; Giardino, R.; Migliaresi, C. The healing of confined critical size cancellous defects in the presence of silk fibroin hydrogel. Biomaterials 2005, 26, 3527-3536.
91. Zuglul, A.H.; Mitsuo, A.; Kiyoshi, H. Mechanism of the gelation of fibroin solution. Biosci. Biotechnol. Biochem. 1993, 57, 1910-1912.
92. Kang, G.D.; Nahm, J.H.; Park, J.S.; Moon, J.Y.; Cho, C.S.; Yeo, J.H. Effects of poloxamer on the gelation of silk fibroin. Macromol. Rapid Commun. 2002, 21, 788-791.
93. Nazarov, R.; Jin, H.J.; Kaplan, D.L. Porous 3-D scaffolds from regenerated silk fibroin. Biomacromolecules 2004, 5, 718-726.
94. Tamada, Y. New Process to form a silk fibroin porous 3-D structure. Biomacromolecules 2005, 6, 3100-3106.
95. Wang, Y.; Kim, U.J.; Blasioli, D.J.; Kim, H.J.; Kaplan, D.L. In vitro cartilage tissue engineering with 3-D porous aqueous-derived silk scaffolds and mesenchymal stem cells. Biomaterials 2005, 26, 7082-7094.
96. Wang, Y.; Blasioli, D.J.; Kim, H.J.; Kim, H.S.; Kaplan, D.L. Cartilage tissue engineering with silk scaffolds and human articular chondrocytes. Biomaterials 2006, 27, 4434-4442
97. Tachibana, A.; Kaneko, S.; Tanabe, T.; Yamauchi, K. Rapid fabrication of keratin-hydroxyapatite hydrid sponges toward osteoblast cultivation and differentiation. Biomaterials 2005, 26, 297-302.
98. Ritzoulis, C.; Scoutaris, N.; Papademetriou, K.; Stavroulias, S.; Panayiotou, C. Milk protein-based emulsion gels for bone tissue engineering. Food Hydrocolloids 2005, 19, 575-581.
99. MacNeil, S. Biomaterials for tissue engineering of skin. Mater. Today 2008, 11, 26-35.
100. Kumba, S.G.; Nukavarapu, S.P.; James, R.; Nair, L.S.; Laurencin, C.T. Electrospun poly (lactic acid- co- glycolic acid) scaffolds for skin tissue engineering. Biomaterials 2008, 29, 4100-4107.
101. Krasna, M.; Planinsek, F.; Knezevic, M.; Arnez, Z.M.; Jeras, M. Evaluation of a fibrin-based skin substitute prepared in a defined keratinocyte medium. Int. J. Pharm. 2005, 291, 31-37.
102. Wu, X.M.; Kathuria, N.; Patrick, C.W.; Reece, G.P. Quantitative analysis of the microvasculature growing in the fibrin interface between a skin graft and the recipient site. Microvasc. Res. 2008, 75, 119-129. Materials 2009, 2 633
103. Merone, A.; Sergio, M.; Daniela, C.; Vanessa, T.; Giovanni, S. The use of Integra in Paediatrics. Burns 2007, 33, S121-S122.
104. Bello, Y.M.; Falabella, A.F. The role of Graftskin (Apligraf) in difficult-to-heal venous leg ulcers. J. Wound Care 2003, 11, 182-183.
105. Horch, R.E.; Kopp, J.; Kneser, U.; Beier, J.; Bach, A.D. Tissue engineering of cultured skin substitutes. J. Cell. Mol. Med. 2005, 9, 592-608.
106. King, W.W.K.; Lam, P.K.; Liew, C.T.; Ho, W.S.; Li, A.K.C. Evaluation of artificial skin (Integra) in a rodent model. Burns 1997, 23, S30-S32.
107. Baker, S.; Iorio, A.R. Application of Apligraf skin graft substitute along with autologous platelet derived growth factors in the treatment of diabetic foot ulcer. The Foot 2008, 18, 181-182.
108. Venugopal, J.R.; Zhang, Y.; Ramakrishna, S. In vitro culture of human dermal fibroblasts on electrospun polycaprolactone collagen nanofibrous membrane. Artif. Organs 2006, 30, 440-446.
109. Dunn, M.G.; Liesch, J.B.; Tiku, M.L.; Zawadsky, J.P. Development of fibroblast-seeded ligament analogs for ACL reconstruction. J. Biomed. Mater. Res. 1995, 29, 1363-1371.
110. Altman, G.H.; Horan, R.L.; Lu, H.H.; Moreau, J.; Martin, I.; Richmond, J.C.; Kaplan, D.L. Silk matrix for tissue engineered anterior cruciate ligaments. Biomaterials 2002, 23, 4131-4141.
111. Liu, H.; Fang, H.; Wang, Y.; Toh, S.L.; Goh, J.C.H. The interaction between a combined knitted silk scaffold and microporous silk sponge with human mesenchymal stem cells for ligament tissue engineering. Biomaterials 2008, 29, 662-674.
112. Laurencin, C.T.; Freeman, J.W. Ligament tissue engineering: an evolutionary materials science approach. Biomaterials 2005, 26, 7530-7536.
113. Chen, X.; Qi, Y.Y.; Wang, L.L.; Yin, Z.; Yin, G.L.; Zou, X.H.; Quyang, H.W. Ligament regeneration using a knitted silk scaffold combined with collagen matrix. Biomaterials 2008, 29, 3683-3692.
114. Shaikh, F.M.; Callanan, A.; Kavanagh, E.G.; Burke, P.E.; Grace, P.A.; McGloughlin, T.M. Fibrin: a natural biodegradable scaffold in vascular tissue engineering. Cells Tissues Organs 2008, 188, 333-346.
115. Ye, Q.; Zund, G.; Benedikt, P.; Jockenhoevel, S.; Hoerstrup, S.P.; Sakyama, S.; Hubbell, J.A.; Turina, M. Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering. Eur. J. Cardiothorac. Sur. 2000, 17, 587-591.
116. Jockenhoevel, S.; Zund, G.; Hoerstrup, S.P.; Chalabi, K.; Sachweh, J.S.; Demircan, L.; Messmer, B.J.; Turina, M. Fibrin gel-advantages of a new scaffold in cardiovascular tissue engineering. Eur. J. Cardiothorac. Surg. 2001, 19, 424-430.
117. Mol, A.; van Lieshout, M.I.; Dam-de Veen, C.G.; Neuenschwander, S.; Hoerstrup, S.P.; Baaijens, F.P.T.; Bouten, C.V.C. Fibrin as a cell carrier in cardiovascular tissue engineering applications. Biomaterials 2005, 26, 3113-3121.
118. Boccafoschi, F.; Habermehl, J.; Vesentini, S.; Mantovani, D. Biological performances of collagen-based scaffolds for vascular tissue engineering. Biomaterials 2005, 26, 7410-7417.
119. Tillman, B.W.; Yazdani, S.K.; Lee, S.J.; Geary, R.L. Atala, A.; Yoo, J.J. The in vivo stability of electrospun polycaprolactone-collagen scaffolds in vascular reconstruction. Biomaterials 2009, 30, 583-588. Materials 2009, 2 634
120. Yin, G.B.; Zhang, Y.Z.; Bao, W.W.; Wu, J.L.; Shi,.B.; Dong, Z.H.; Fu, W.G. Study on the properties of the electrospun silk fibroin/gelatin blend nanofibers for scaffolds. J. Appl. Polym. Sci. 2009, 111, 1471-1477.
121. Quaglia, F. Bioinspired tissue engineering: the great promise of protein delivery technologies. Int. J. Pharm. 2008, 364, 281-297.
122. Tabata, Y. Recent progress in tissue engineering. Drug Disc. Today 2001, 6, 483-487.
123. Lee, K.Y.; Peters, M.C.; Anderson, K.W.; Mooney, D.J. Controlled growth factor release from synthetic extracellular matrices. Nature 2000, 408, 998-1000.
124. Richardson, T.P.; Peters, M.C.; Ennett, A.B.; Mooney, D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 2001, 19, 1029-1034.
125. Tabata, Y. The importance of drug delivery systems in tissue engineering. Pharm. Sci. Technol. Today 2000, 3, 80-89.
126. Ueda, H.; Nakamura, T.; Yamamoto, M.; Nagata, N.; Fukuda, S.; Tabata, Y.; Shimizu, Y. Repairing of rabbit skull defect by dehydrothermally crosslinked collagen sponges incorporating transforming growth factor β1. J. Control. Rel. 2003, 88, 55-64.
127. Kirker-Head, C.A. Potential applications and delivery strategies for bone morphogenetic proteins. Adv. Drug Deliv. Rev. 2000, 43, 65-92.
128. Geiger, M.; Li, R.H.; Friess, W. Collagen sponges for bone regeneration with rhBMP-2. Adv. Drug Deliv. Rev. 2003, 55, 1613-1629.
129. Bhang, S.H.; Lee, T.J.; Lim, J.M.; Lim, J.S.; Han, A.M.; Choi, C.Y.; Kwon, Y.H.K.; Kim, B.S. The effect of the controlled release of nerve growth factor from collagen gel on the efficiency of neural cell culture. Biomaterials 2009, 30, 126-132.
130. Shen, Y.H.; Shoichet, M.S.; Radisic, M. Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells. Acta Biomater. 2008, 4, 477-489.
131. Bauer, S.M.; Bauer, R.J.; Liu, Z.J.; Chen, H.; Goldstein, L.; Velazquez, O.C. Vascular endothelial growth factor-C promotes vasculogenesis, angiogenesis, and collagen constriction in three-dimensional collagen gels. J. Vasc. Surg. 2005, 41, 699-707.
132. Kirker-Head, C.; Karageorgiou, V.; Hofmann, S.; Fajardo, R.; Betz, O.; Merkle, H.P.; Hilbe, M.; von Rechenberg, B.; McCool, J.; Abrahamsen, L.; Nazarian, A.; Cory, E.; Curtis, M.; Kaplan, D.; Meinel, L. BMP-silk composite matrices heal critically sized femoral defects. Bone 2007, 41, 247-255.
133. Yamamoto, M.; Ikada, Y.; Tabata, Y. Controlled release of growth factors based on biodegradation of gelatin hydrogel. J. Biomater. Sci. Polym. Ed. 2001, 12, 77-88.
134. Young, S.; Wong, M.; Tabata, Y.; Mikos, A.G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J. Control. Rel. 2005, 109, 256-274.
135. Willerth, S.M.; Rader, A.; Sakiyama-Elbert, S.E. The effect of controlled growth factor delivery on embryonic stem cell differentiation inside fibrin scaffolds. Stem Cell Res. 2008, 1, 205-218.
136. Willerth, S.M.; Faxel, T.E.; Gottlieb, D.I.; Sakiyama-Elbert, S.E. The effects of soluble growth factors on embryonic stem cell differentiation inside of fibrin scaffolds. Stem Cells 2007, 25, 2235-2244. Materials 2009, 2 635
137. Sakiyama-Elbert, S.E.; Hubbell, J.A. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell in growth matrix. J. Control. Rel. 2000, 69, 149-158.
138. Ehrbar, M.; Zeisberger, S.M.; Raeber, G.P.; Hubbell, J.A.; Schnell, C.; Zisch, A.H. The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis. Biomaterials 2008, 29, 1720-1729.
139. Patel, Z.S.; Yamamoto, M.; Ueda, H.; Tabata, Y.; Mikos, A.G. Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2. Acta Biomater. 2008, 4, 1126-1138.
140. van Amerongen, M.J.; Harmsen, M.C.; Petersen, A.H.; Kors, G.; van Luyn, M.J.A. The enzymatic degradation of scaffolds and their replacement by vascularized extracellular matrix in the murine myocardium. Biomaterials 2006, 27, 2247-2257.
141. Horan, R.L.; Antle, K.; Collette, A.L.; Wang, Y.; Huang, J.; Moreau, J.E.; Volloch, V.; Kaplan, D.L.; Altman, G.H. In vitro degradation of silk fibroin. Biomaterials 2005, 26, 3385-3393.
142. Li, J.P.; Habibovic, P.; van den Doel, M.; Wilson, C.E.; de Wijn, J.R.; van Blitterswijk, C.A.; de Groot, K. Bone ingrowth in porous titanium implants produced by 3D fiber deposition. Biomaterials 2007, 28, 2810-2820.
143. Ratner, B.D.; Hoffman, A.S.; Schoen, F.J.; Lemons, J.E. Biomaterials Science: An Introduction to Materials and Medicine, 2nd ed.; Elsevier: Oxford, UK, 2004.
144. Cox, G.; Crossley, J.; Xing, Z. Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am. J. Respir. Cell Mol. Biol. 1995, 12, 232-237.
145. Gigg, J.M.; Savill, J.S.; Sarraf, C.; Haslett, C.; Silverman, M. Neutrophil apotosis and clearance from neonatal lungs. Lancet 1991, 338, 720-722.