Potential applications and delivery strategies for bone morphogenetic proteins

Advanced Drug Delivery Reviews

Volumn 43, Issue 1, 2000, Pages 65-92

  Kirker Head, Carl A ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Cell therapy; Cytokine; Gene therapy; Matrix; Organogenesis; Osteoinduction

Indexed keywords

BONE; DISEASES; GENE TRANSFER; PROTEINS; SURGERY;

CELL THERAPY; CYTOKINE; GENE THERAPY; ORGANOGENESIS; OSTEOINDUCTION;

CONTROLLED DRUG DELIVERY;

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CALCIUM PHOSPHATE; COLLAGEN; DRUG CARRIER; HYDROXYAPATITE; POLYGLACTIN; POLYGLYCOLIC ACID; POLYLACTIC ACID; RECOMBINANT PROTEIN; TITANIUM; TRANSFORMING GROWTH FACTOR ALPHA;

BONE GRAFT; BONE MATRIX; BONE REGENERATION; DRUG DELIVERY SYSTEM; FRACTURE; GENE THERAPY; GENE TRANSFER; HUMAN; HYDROGEL; MAXILLOFACIAL SURGERY; NONHUMAN; OSSIFICATION; PERIODONTAL DISEASE; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; REVIEW; SPINE FUSION;

EID: 0034666480     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00078-8     Document Type: Article

References (355)

1. Urist M.R. Bone: formation by autoinduction. Science. 150:1965;893-899.
2. Wang E.A., Rosen V., Cordes P., Hewick R.M., Kriz J.J., Luxenberg D.P., Sibley B.S., Wozney J.M. Purification and characterization of other distinct bone-inducing factors. Proc. Nat. Acad. Sci. USA. 85:1988;9484-9488.
3. Johnson E.E., Urist M.R., Finerman G.A. Bone morphogenetic protein augmentation grafting of resistant femoral nonunions: A preliminary report. Clin. Orthop. 230:1988;257-265.
4. Johnson E.E., Urist M.R., Finerman G.A. Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein: A preliminary report. Clin. Orthop. 236:1988;249-257.
5. Johnson E.E., Urist M.R., Finerman G.A.M. Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone. Clin. Orthop. 277:1992;229-237.
6. Takaoka K., Nakahara H., Yoshikawa H., Masuhara K., Tsuda T., Ono K. Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein. Clin. Orthop. 234:1988;250-254.
7. Takaoka K., Yoshikawa H., Hashimoto J., Miyamoto S., Suzuki S., Matsui M., Ono K. Purification and characterization of a bone-inducing protein from a murine osteosarcoma. Clin. Orthop. 292:1993;329-336.
8. Takaoka K., Yoshikawa H., Shimizu N., Ono K., Amitani K., Nakata Y. Partial purification of bone-inducing substances from a murine osteosarcoma. Clin. Orthop. 164:1982;265-270.
9. Nakahara H., Takaoka K., Koezuka M., Sugamoto K., Tsuda T., Ono K. Periosteal bone formation elicited by partially purified bone morphogenetic protein. Clin. Orthop. 239:1989;299-305.
10. Horisaka Y., Okamoto Y., Matsumoto N., Yoshimura Y., Kawada J., Yamashita K., Takagi T. Subperiosteal implantation of bone morphogenetic protein adsorbed to hydroxyapatite. Clin. Orthop. 268:1991;303-312.
11. Urist M.R., Mikulski A., Lietze A. Solubilized and insolubilized bone morphogenetic protein. Proc. Nat. Acad. Sci. USA. 76:1979;1828-1832.
12. Ma G., Zhu X.Z. Clinical observation on repair of bone defects in maxillofacial region by grafting hydroxylapatite combined with porcine bone morphogenetic protein. Chung Hua Kou Chiang Hsueh Tsa Chih. 29:1994;223-225.
13. Bessho K., Iizuka T. Activity and solubility of bone morphogenetic protein derived from porcine bone matrix. Br. J. Oral Maxillofac. Surg. 32:1994;86-90.
14. Herr G., Wahl D., Kusswetter W. Osteogenic activity of bone morphogenetic protein and hydroxyapatite composite implants. Ann. Chir. Gynaecol. Suppl. 207:1993;99-107.
15. Jortikka L., Marttinen A., Lindholm T.S. Partially purified reindeer (Rangifer tarandus) bone morphogenetic protein has a high bone-forming activity compared with some other artiodactyls. Clin. Orthop. 297:1993;33-37.
16. Jiang D.D., Ou B.P. Extraction of swine bone morphogenetic protein and observations on its osteoinductive bioactivity by heterogenic intramuscular implantations and repair of experimental skull defects. Chung Hua Wai Ko Tsa Chih. 26:1988;56-58.
17. Hu X.B., Wu Z.Y. Purification of porcine bone morphogenetic protein and study of its osteo-inductive activity. Chung Hua Wai Ko Tsa Chih. 26:1988;52-55.
18. Hotz G., Herr G. Bone substitute with osteoinductive biomaterials - current and future clinical applications. Int. J. Oral Maxillofac. Surg. 23:1994;413-417.
19. Viljanen V.V., Lindholm T.C., Gao T.J., Lindholm T.S. Low dosage of native allogeneic bone morphogenetic protein in repair of sheep calvarial defects. Int. J. Oral Maxillofac. Surg. 26:1997;389-393.
20. Strayhorn C.L., Garrett J.S., Dunn R.L., Benedict J.J., Somerman M.J. Growth factors regulate expression of osteoblast-associated genes. J. Periodontol. 70:1999;1345-1354.
21. Boden S.D. Bioactive factors for bone Tissue Eng. Clin. Orthop. 367:1999;S84-S94.
22. Nagai N., Qin C.L., Nagatsuka H., Inoue M., Ishiwari Y. Age effects on ectopic bone formation induced by purified bone morphogenetic protein. Int. J. Oral Maxillofac. Surg. 28:1999;143-150.
23. Kuboki Y., Sasaki M., Saito A., Takita H., Kato H. Regeneration of periodontal ligament and cementum by BMP-applied tissue engineering. Eur. J. Oral Sci. 106:1998;S197-S203.
24. Kuboki Y., Takita H., Kobayashi D., Tsuruga E., Inoue M., Murata M., Nagai N., Dohi Y., Ohgushi H. BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. J. Biomed. Mater. Res. 39:1998;190-199.
25. Sun Y., Zhang W., Ma F., Chen W., Hou S. Evaluation of transforming growth factor beta and bone morphogenetic protein composite on healing of bone defects. Chin. Med. J. 110:1997;927-931.
26. Asahina I., Watanabe M., Sakurai N., Mori M., Enomoto S. Repair of bone defect in primate mandible using a bone morphogenetic protein (BMP)-hydroxyapatite-collagen composite. J. Med. Dent. Sci. 44:1997;63-70.
27. Sciadini M.F., Dawson J.M., Johnson K.D. Evaluation of bovine-derived bone protein with a natural coral carrier as a bone-graft substitute in a canine segmental defect model. J. Orthop. Res. 15:1997;844-857.
28. Sciadini M.F., Dawson J.M., Johnson K.D. Bovine-derived bone protein as a bone graft substitute in a canine segmental defect model. J. Orthop. Trauma. 11:1997;496-508.
29. Levine J.P., Bradley J., Turk A.E., Ricci J.L., Benedict J.J., Steiner G., Longaker M.T., McCarthy J.G. Bone morphogenetic protein promotes vascularization and osteoinduction in preformed hydroxyapatite in the rabbit. Ann. Plast. Surg. 39:1997;158-168.
30. Ijiri S., Nakamura T., Fujisawa Y., Hazama M., Komatsudani S. Ectopic bone induction in porous apatite-wollastonite-containing glass ceramic combined with bone morphogenetic protein. J. Biomed. Mater. Res. 35:1997;421-432.
31. Kawakami T., Kawai T., Takei N., Kise T., Eda S., Urist M.R. Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. Clin. Orthop. 337:1997;261-266.
32. Cui P.C., Chen W.X., Zhou H.M. Repair of thyroid cartilage defect with bone morphogenetic protein. Ann. Otol. Rhinol. Laryngol. 106:1997;326-328.
33. Bai M.H., Liu X.Y., Yallg C., Chen D.A. An implant of a composite of bovine bone morphogenetic protein and plaster of paris for treatment of femoral shaft nonunions. Int. Surg. 81:1996;390-392.
34. Zellin G., Hedner E., Linde A. Bone regeneration by a combination of osteopromotive membranes with different BMP preparations: a review. Connect Tissue Res. 35:1996;279-284.
35. Yamazaki Y., Oida S., Ishihara K., Nakabayashi N. Ectopic induction of cartilage and bone by bovine bone morphogenetic protein using a biodegradable polymeric reservoir. J. Biomed. Mater. Res. 30:1996;1-4.
36. Miki T., Imai Y. Osteoinductive potential of freeze-dried,biodegradable, poly (glycolicacid-co-lactic acid) disks incorporated with bone morphogenetic protein in skull defects of rats. Int. J. Oral Maxillofac. Surg. 25:1996;402-406.
37. Gao Y., Fang Y.R., Suwa F., Yoshida S., Yang L., Tanaka A. Induction of reparative dentin formation in dogs by bovine bone morphogenetic protein bound to ceramic dentin. J. Osaka. Dent. Univ. 29:1995;29-38.
38. Wang X., Jin Y., Liu B., Zhou S., Yang L., Yang X., White F.H. Tissue reactions to titanium implants containing bovine bone morphogenetic protein: A scanning electron microscopic investigation. Int. J. Oral Maxillofac. Surg. 23:1994;115-159.
39. Sailer H.F., Kolb E. Application of purified bone morphogenetic protein (BMP) preparations in cranio-maxillo-facial surgery. Reconstruction in craniofacial malformations and post-traumatic or operative defects of the skull with lyophilized cartilage and BMP. J. Craniomaxillofac. Surg. 22:1994;191-199.
40. Cook S.D., Baffes G.C., Wolfe M.W., Sampath T.K., Rueger D.C., Whitecloud T.S. 3rd. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J. Bone. Joint Surg. Am. 76:1994;827-838.
41. Sailer H.F., Kolb E. Application of purified bone morphogenetic protein (BMP) in cranio-maxillo-facial surgery. BMP in compromised surgical reconstructions using titanium implants. J. Craniomaxillofac. Surg. 22:1994;2-11.
42. Yan J., Xiang W., Baolin L., White F.H. Early histologic response to titanium implants complexed with bovine bone morphogenetic protein. J. Prosthet. Dent. 71:1994;289-294.
43. Lindholm T.C., Lindholm T.S., Marttinen A., Urist M.R. Bovine bone morphogenetic protein (bBMP/NCP)-induced repair of skull trephine defects in pigs. Clin. Orthop. 301:1994;263-270.
44. Miki T., Harada K., Imai Y., Enomoto S. Effect of freeze-dried poly-L-lactic acid discs mixed with bone morphogenetic protein on the healing of rat skull defects. J. Oral Maxillofac. Surg. 52:1994;387-391.
45. Horisaka Y., Okamoto Y., Matsumoto N., Yoshimura Y., Hirano A., Nishida M., Kawada J., Yamashita K., Takagi K. Histological changes of implanted collagen material during bone induction. J. Biomed. Mater. Res. 28:1994;97-103.
46. Pajamaki K.J., Andersson O.H., Lindholm T.S., Karlsson K.H., Yli-Urpo A., Happonen R.P. Effect of bovine bone morphogenetic protein and bioactive glass on demineralized bone matrix grafts in the rat muscular pouch. Ann. Chir. Gynaecol. Suppl. 207:1993;155-161.
47. Damien C.J., Christel P.S., Benedict J.J., Patat J.L., Guillemin G. A composite of natural coral, collagen, bone protein and basic fibroblast growth factor tested in a rat subcutaneous model. Ann. Chir. Gynaecol. Suppl. 207:1993;117-128.
48. Shigenobu K., Kaneda K., Nagai N., Kuboki Y. Localization of bone morphogenetic protein-induced bone and cartilage formation on a new carrier: fibrous collagen membrane. Ann. Chir. Gynaecol. Suppl. 207:1993;85-90.
49. Gao T.J., Lindholm T.S., Marttinen A., Puolakka T. Bone inductive potential and dose-dependent response of bovine bone morphogenetic protein combined with Type IV collagen carrier. Ann. Chir. Gynaecol. Suppl. 207:1993;77-84.
50. Viljanen V.V., Lindholm T.S. Heterotopic osteoinduction in a rat membrane-isolated latissimus dorsi island flap. A pilot study. Ann. Chir. Gynaecol. Suppl. 207:1993;55-62.
51. Marden L.J., Fan R.S., Pierce G.F., Reddi A.H., Hollinger J.O. Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects. J. Clin. Invest. 92:1993;2897-2905.
52. Kawakami T., Uji H., Antoh M., Hasegawa H., Kise T., Eda S. Squalane as a possible carrier of bone morphogenetic protein. Biomaterials. 14:1993;575-577.
53. Xiang W., Baolin L., Yan J., Yang X. The effect of bone morphogenetic protein on osseointegration of titanium implants. J. Oral Maxillofac. Surg. 51:1993;647-651.
54. Katoh T., Sato K., Kawamura M., Iwata H., Miura T. Osteogenesis in sintered bone combined with bovine bone morphogenetic protein. Clin. Orthop. 287:1993;266-275.
55. Johnson E.E., Urist M.R., Schmalzried T.P., Chotivichit A., Huang H.K., Finerman G.A. Autogeneic cancellous bone grafts in extensive segmental ulnar defects in dogs. Effects of xenogeneic bovine bone morphogenetic protein without and with interposition of soft tissues and interruption of blood supply. Clin. Orthop. 243:1989;254-265.
56. Mahy P.R., Urist M.R. Experimental heterotopic bone formation induced by bone morphogenetic protein and recombinant human interleukin-1B. Clin. Orthop. 237:1988;236-244.
57. Horiuchi K., Yoshida S., Shohara E., Sugimura M. Experimental study of xenogeneic osteogenesis using bovine sintered bone 'true bone ceramic (TBC)' combined with bovine bone morphogenetic protein (bBMP). Dtsch. Zahnarztl. Z. 43:1988;93-96.
58. Lindholm T.C., Lindholm T.S., Alitalo I., Urist M.R. Bovine bone morphogenetic protein (bBMP) induced repair of skull trephine defects in sheep. Clin. Orthop. 227:1988;265-268.
59. Ferguson D., Davis W.L., Urist M.R., Hurt W.C., Allen E.P. Bovine bone morphogenetic protein (bBMP) fraction-induced repair of craniotomy defects in the rhesus monkey (Macaca speciosa). Clin. Orthop. 219:1987;251-258.
60. Urist M.R., Nilsson O., Rasmussen J., Hirota W., Lovell T., Schmalzreid T., Finerman G.A. Bone regeneration under the influence of a bone morphogenetic protein (BMP) beta tricalcium phosphate (TCP) composite in skull trephine defects in dogs. Clin. Orthop. 214:1987;295-304.
61. Nilsson O.S., Urist M.R., Dawson E.G., Schmalzried T.P., Finerman G.A. Bone repair induced by bone morphogenetic protein in ulnar defects in dogs. J. Bone Joint Surg. Br. 68:1986;635-642.
62. Urist M.R., Kovacs S., Yates K.A. Regeneration of an enchondroma defect under the influence of an implant of human bone morphogenetic protein. J. Hand Surg. Am. 11:1986;417-419.
63. Sato K., Urist M.R. Induced regeneration of calvaria by bone morphogenetic protein (BMP) in dogs. Clin. Orthop. 197:1985;301-311.
64. Nilsson O., Urist M.R. Response of the rabbit metaphysis to implants of bovine bone morphogenetic protein (bBMP). Clin. Orthop. 195:1985;275-281.
65. Takagi K., Urist M.R. The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects. Ann. Surg. 196:1982;100-109.
66. Gao T.J., Lindholm T.S., Kommonen B., Ragni P., Paronzini A., Lindholm T.C., Jalovaara P., Urist M.R. The use of a coral composite implant containing bone morphogenetic protein to repair a segmental tibial defect in sheep. Int. Orthop. 21:1997;194-200.
67. Viljanen V.V., Gao T.J., Marttinen A., Lindholm T.S. Partial purification and characterization of bone morphogenetic protein from bone matrix of the premature moose (Alces alces): degradation of bone-inducing activity during storage. Eur. Surg. Res. 28:1996;447-460.
68. Gao T., Lindholm T.S., Marttinen A., Urist M.R. Composites of bone morphogenetic protein (BMP) and Type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics. Int. Orthop. 20:1996;321-325.
69. Viljanen V.V., Gao T.J., Lindholm T.C., Lindholm T.S., Kommonen B. Xenogeneic moose (Alces alces) bone morphogenetic protein (mBMP)-induced repair of critical-size skull defects in sheep. Int. J. Oral Maxillofac. Surg. 25:1996;217-222.
70. Ripamonti U., Ma S.S., Cunningham N.S., Yeates L., Reddi A.H. Reconstruction of the bone-bone marrow organ by osteogenin, a bone morphogenetic protein, and demineralized bone matrix in calvarial defects of adult primates. Plast. Reconstr. Surg. 91:1993;27-36.
71. Ripamonti U., Ma S., Cunningham N.S., Yeates L., Reddi A.H. Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein. Matrix. 12:1992;369-380.
72. Ripamonti U. Calvarial regeneration in primates with autolyzed antigen-extracted allogeneic bone. Clin. Orthop. 282:1992;293-303.
73. Bessho K., Kusumoto K., Fujimura K., Konishi Y., Ogawa Y., Tani Y., Iizuka T. Comparison of recombinant and purified human bone morphogenetic protein. Br. J. Oral Maxillofac. Surg. 37:1999;2-5.
74. Johnson E.E., Urist M.R. One-stage lengthening of femoral nonunion augmented with human bone morphogenetic protein. Clin. Orthop. 347:1998;105-116.
75. Sun Y., Ma G., Li D. Repair of large cranial defect using allogeneic cranial bone and bone morphogenetic protein. Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 11:1995;8-9.
76. Urist M.R., Hudak R.T. Radioimmunoassay of bone morphogenetic protein in serum: a tissue-specific parameter of bone metabolism. Proc. Soc. Exp. Biol. Med. 176:1984;472-475.
77. Urist M.R., Sato K., Brownell A.G., Malinin T.I., Lietze A., Huo Y.K., Prolo D.J., Oklund S., Finerman G.A., DeLange R.J. Human bone morphogenetic protein (hBMP). Proc. Soc. Exp. Biol. Med. 173:1983;194-199.
78. Wozney J.M. The bone morphogenetic protein family and osteogenesis. Mol. Rep. Dev. 32:1992;160-167.
79. Wozney J.M. The bone morphogenetic protein family and osteogenesis. Mol. Rep. Dev. 32:1992;160-167.
80. Celeste A.J., Taylor R., Yamaji N. Molecular cloning of BMP-8: A protein present in bovine bone which is highly related to the BMP-5/6/7 subfamily of osteoinductive molecules. J. Cell Biochem. Suppl. 16F:1992;100.
81. Redd A.H. Intitiation of fracture repair by bone morphogenetic proteins. Clin. Orthop. 3555:1998;S66-S72.
82. Sampath T.K., Maliakal J.C., Hauschka P.V., Jones W.K., Sasak H., Tucker R.F., White K.H., Coughlin J.E., Tucker M.M., Pang R.H. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J. Biol. Chem. 267:1992;20352-20362.
83. Wozney J.M., Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin. Orthop. 346:1998;26-37.
84. Croteau S., Rauch F., Silvestri A., Hamdy R.C. Bone morphogenetic proteins in orthopedics: from basic science to clinical practice. Orthopedics. 22:1999;686-695.
85. Sampath T.K., Coughlin J.E., Whetstone R.M., Banach D., Corbett C., Ridge R.J., Ozkaynak E., Oppermann H., Rueger D.C. Bovine osteogenic protein is composed of dimers of OP-1 and BMP2A, two members of the transforming growth factor beta superfamily. J. Biol. Chem. 265:1990;13198-13250.
86. Kawabata M., Imamura T., Miyazono K. Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev. 9:1998;49-61.
87. Sampath T.K., Rashka K.E., Doctor J.S., Tucker R.F., Hoffmann F.M. Drosophila transforming growth factor superfamily proteins induce endochondral bone formation in mammals. Proc. Natl. Acad. Sci. USA. 90:1993;6004-6008.
88. Padgett R.W., Wozney J.M., Gelbart W.M. Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc. Natl. Acad. Sci. USA. 90:1993;2905-2909.
89. Ferguson C.M., Miclau T., Hu D., Alpern E., Helms J.A. Common molecular pathways in skeletal morphogenesis and repair. Ann. NY Acad. Sci. 857:1998;33-42.
90. Karsenty G. Genetics of skeletogenesis. Dev. Genet. 22:1998;301-313.
91. Reddi A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat. Biotechnol. 16:1998;247-252.
92. Barth K.A., Kishimoto Y., Rohr K.B., Seydler C., Schulte-Merker S., Wilson S.W. Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development. 126:1999;4977-4987.
93. Farkas L.M., Jaszai J., Unsicker K., Krieglstein K. Characterization of bone morphogenetic protein family members as neurotrophic factors for cultured sensory neurons. J. Neurosci. 92:1999;227-235.
94. Mabie P.C., Mehler M.F., Kessler J.A. Multiple roles of bonemorphogenetic protein signaling in the regulation of cortical cell number and phenotype. J. Neurosci. 19:1999;7077-7088.
95. Mehler M.F., Mabie P.C., Zhang D., Kessler J.A. Bone morphogenetic proteins in the nervous system. Trends Neurosci. 20:1997;309-317.
96. Peters H., Balling R. Teeth: where and how to make them. Trends Genet. 15:1999;59-65.
97. Mohan R.R., Kim W.J., Mohan R.R., Chen L., Wilson S.E. Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea. Invest. Ophthalmol. Vis. Sci. 39:1998;2626-2636.
98. Mohan R.R., Kim W.J., Mohan R.R., Chen L., Wilson S.E. Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea. Invest. Ophthalmol. Vis. Sci. 39:1998;2626-2636.
99. You L., Kruse F.E., Pohl J., Volcker H.E. Bone morphogenetic proteins and growth and differentiation factors in the human cornea. Invest. Ophthalmol. Vis. Sci. 40:1999;296-311.
100. Özkaynak E., Oppermann S., Schnegelsberg D.N. Murine osteogenic protein (OP-1): High levels of mRNA in kidney. Biochem. Biophys. Res. Comm. 179:1991;116-123.
101. Harris S.E., Harris M.A., Mahy P., Wozney J., Feng J.Q., Mundy G.R. Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate cancer cells. Prostate. 24:1994;204-211.
102. Shimasaki S., Zachow R.J., Li D., Kim H., Iemura S., Ueno N., Sampath K., Chang R.J., Erickson G.F. A functional bone morphogenetic protein system in the ovary. Proc. Nat. Acad. Sci. USA. 96:1999;7282-7287.
103. Sakou T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone. 22:1998;591-603.
104. Ganan Y., Macias D., Duterque-Coquillaud M., Ros M.A., Hurle J.M. Role of TFG-βs and BMP's as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod. Development. 122:1996;2349.
105. Zou H., Niswander L. Requirement for BMP signaling in interdigital apoptosis and scale formation. Science. 272:1996;738.
106. Lianjia Y., Yan J. Immunohistochemical observations on bone morphogenetic protein in normal and abnormal conditions. Clin. Orthop. 257:1990;249-256.
107. Bostrom M.P. Expression of bone morphogenetic proteins in fracture healing. Clin. Orthop. 355:1998;S116-S123.
108. Bostrom M.P., Saleh K.J., Einhorn T.A. Osteoinductive growth factors in preclinical fracture and long bone defects models. Clin. Orthop. 30:1999;647-658.
109. Lane J.M., Cornell C.N., Werntz J.R. Clinical applications of biosynthetics. Friedlaender G.E., Goldberg V.M. Bone and Cartilage Allografts. 1989;279-294 American Academy of Orthopedic Surgeons, Park Ridge, IL.
110. Boero M.J., Schneider J.E., Mosier J.E., Guffy M.M., Butler H.C., Leipold H.W. Evaluation of the tibia as a source of autogenous cancellous bone in the horse. Vet. Surg. 18:1989;322-327.
111. Horowitz M.C., Friedlaender G.E. The immune response to bone grafts. Friedlaender G.E., Goldberg V.M. Bone and Cartilage Allografts. 1989;85-103 American Academy of Orthopedic Surgeons, Park Ridge, IL.
112. M.D. Strong, M.H. Sayers, E.U. Conrad, Screening tissue donors for infectious markers, in: G.E. Friedlaender, V.M. Goldberg (Eds.), Bone and Cartilage Allografts, American Academy of Orthopedic Surgeons, Park Ridge, IL, 1989, pp. 193-211.
113. Tomford W.W., Doppelt S.H., Mankin H.J. Organization, legal aspects and problems of bone banking in a large orthopedic center. Aebi M., Regazzoni P. Bone Transplantation. 1988;145-151 Springer-Verlag, Berlin.
114. Ripamonti U., Duneas N. Tissue morphogenesis and regeneration by bone morphogenetic proteins. Plast. Reconstr. Surg. 101:1998;227-239.
115. Winn S.R., Uludag H., Hollinger J.O. Carrier systems for bone morphogenetic proteins. Clin. Orthop. Suppl. 367:1999;S95-S106.
116. Cook S.D., Baffes G.C., Wolfe M.W., Sampath T.K., Rueger D.C. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin. Orthop. 301:1994;302-312.
117. T.R. Hunt, H.H.T. Hsu, D.C. Morris, J.R. Schwappach, R.G. Lark, H.C. Anderson, Healing of a segmental defect in the rat femur using a bone inducing agent (BIA) derived from a cultured human osteosarcoma cell line (saos-2). Trans. 39th Ann. Orthop. Res. Soc. (1993) 489.
118. Wang E.A., Israel D.I., Kelly S., Luxenberg D.P. Bone morphogenetic protein 2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors. 9:1993;57-71.
119. Puleo D.A. Dependence of mesenchymal cell responses on duration of exposure to bone morphogenetic protein-2 in vitro. J. Cell Physiol. 173:1997;93-101.
120. Uludag H., Friess W., Williams D., Porter T., Timony G., D'Augusta D., Blake C., Palmer R., Biron B., Wozney J. RhBMP-collagen sponges as osteoinductive devices: effects of in vitro sponge characteristics and protein pI on in vivo RhBMP pharmacokinetics. Ann. NY Acad. Sci. 875:1999;369-378.
121. Duggirala S.S., Mehta R.C., DeLuca P.P. Interaction of recombinant human bone morphogenetic protein-2 with poly(D,L lactide-co-glycoside) icrospheres. Pharm. Dev. Technol. 1:1996;11-19.
122. De Groot J. Carriers that concentrate native bone morphogenetic protein in vivo. Tiss. Eng. 4:1998;337-341.
123. Luyten F.P., Cunningham N.S., Vucicevic S., Paralkar V., Ripamonti U., Reddi A.H. Advances in osteogenin and related bone morphogenetic proteins in bone induction and repair. Acta. Orthop. Belg. 58:(Suppl. 1):1992;263-267.
124. G.A. Finerman, N. Gerth, M. Urist, Synergistic effects of 19K and 22K BMP. Trans. 38th Ann. Orthop. Res. Soc. (1992) p. 70.
125. Hosokawa R., Kubo T., Wadamoto M., Sato Y., Kimoto T. Direct bone induction in the subperiosteal space of rat calvaria with demineralized bone allografts. J. Oral Implantol. 25:1999;30-34.
126. Uludag H., D'Augusta D., Palmer R., Timony G., Wozney J. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J. Biomed. Mater. Res. 46:1999;193-202.
127. Solheim E. Osteoinduction by demineralised bone. Int. Orthop. 22:1998;335-342.
128. Schwartz Z., Somers A., Mellonig J.T., Carnes D.L. Jr., Wozney J.M., Dean D.D., Cochran D.L., Boyan B.D. Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material. J. Periodontol. 69:1998;1337-1345.
129. Murata M., Inoue M., Arisue M., Kuboki Y., Nagai N. Carrier-dependency of cellular differentiation induced by bone morphogenetic protein in ectopic sites. Int. J. Oral. Maxillofac. Surg. 27:1998;391-396.
130. Viljanen V.V., Gao T.J., Lindholm T.S. Producing vascularized bone by heterotopic bone induction and guided tissue regeneration: a silicone membrane-isolated latissimus dorsi island flap in a rat model. J. Reconstr. Microsurg. 13:1997;207-214.
131. Niederwanger M., Urist M.R. Demineralized bone matrix supplied by bone banks for a carrier of recombinant human bone morphogenetic protein (rhBMP-2): a substitute for autogeneic bone grafts. J. Oral Implantol. 22:1996;210-215.
132. Sigurdsson T.J., Nygaard L., Tatakis D.N., Fu E., Turek T.J., Jin L., Wozney J.M., Wikesjo U.M. Periodontal repair in dogs: evaluation of rhBMP-2 carriers. Int. J. Periodontics Restorative Dent. 16:1996;524-537.
133. Ripamonti U., Van Den Heever B., Sampath T.K., Tucker M.M., Rueger D.C., Reddi A.H. Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7). Growth Factors. 13:1996;273-289.
134. Kirker-Head C.A., Gerhart T.N., Schelling S.H., Hennig G.E., Wang E., Holtrop M.E. Long-term healing of bone using recombinant human bone morphogenetic protein 2. Clin. Orthop. 318:1995;222-230.
135. Cook S.D., Wolfe M.W., Salkeld S.L., Rueger D.C. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J. Bone Joint Surg. Am. 77:1995;734-750.
136. Marden L.J., Hollinger J.O., Chaudhari A., Turek T., Schaub R.G., Ron E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. J. Biomed. Mater. Res. 28:1994;1127-1138.
137. Kenley R., Marden L., Turek T., Jin L., Ron E., Hollinger J.O. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2). J. Biomed. Mater. Res. 28:1994;1139-1147.
138. Gerhart T.N., Kirker-Head C.A., Kriz M.J., Holtrop M.E., Hennig G.E., Hipp J., Schelling S.H., Wang E. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin. Orthop. 293:1986;317-326.
139. Strates B.S., Stock A.J., Connolly J.F. Skeletal repair in the aged: a preliminary study in rabbits. Am. J. Med. Sci. 296:1988;266-269.
140. Harakas N.K. Demineralized bone-matrix-induced osteogenesis. Clin. Orthop. 188:1984;239-251.
141. Takagi K., Urist M.R. The role of bone marrow in bone morphogenetic protein-induced repair of femoral massive diaphyseal defects. Clin. Orthop. 171:1982;224-231.
142. Vail T.B., Trotter G.W., Powers B.E. Equine demineralized bone matrix: Relationship between particle size and osteoinduction. Vet. Surg. 21:1992;409.
143. Takaoka K., Koezuka M., Nakahara H. Telopeptide-depleted bovine skin collagen as a carrier for bone morphogenetic protein. J. Orthop. Res. 9:1991;902-907.
144. Armstrong R., Cooperman L.S., Parkinson T.M. Injectable collagen for soft tissue. Boretos L.M., Eden H.A. Contemporary Biomaterials. 1985;528-536 Hayes Publications, Park Ridge, NJ.
145. Bessho K., Carnes D.L., Cavin R., Chen H.Y., Ong J.L. BMP stimulation of bone response adjacent to titanium implants in vivo. Clin. Oral. Implants Res. 10:1999;212-218.
146. Yoshida K., Bessho K., Fujimura K., Konishi Y., Kusumoto K., Ogawa Y., Iizuka T. Enhancement by recombinant human bone morphogenetic protein-2 of bone formation by means of porous hydroxyapatite in mandibular bone defects. J. Dent. Res. 78:1999;1505-1510.
147. Rodeo S.A., Suzuki K., Deng X.H., Wozney J., Warren R.F. Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel. Am. J. Sports Med. 27:1999;476-488.
148. Geesink R.G., Hoefnagels N.H., Bulstra S.K. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J. Bone Joint Surg. Br. 81:1999;710-718.
149. Winn S.R., Schmitt J.M., Buck D., Hu Y., Grainger D., Hollinger J.O. Tissue-engineered bone biomimetic to regenerate calvarial critical-sized defects in athymic rats. J. Biomed. Mater. Res. 45:1999;414-421.
150. Murata M., Huang B.Z., Shibata T., Imai S., Nagai N., Arisue M. Bone augmentation by recombinant human BMP-2 and collagen on adult rat parietal bone. Int. J. Oral Maxillofac. Surg. 28:1999;232-237.
151. Gordh M., Alberius P., Johnell O., Lindberg L., Linde A. Effects of rhBMP-2 and osteopromotive membranes on experimental bone grafting. Plast Reconstr. Surg. 103:1999;1909-1918.
152. Okubo Y., Bessho K., Fujimura K., Kusumoto K., Ogawa Y., Tani Y., Iizuka T. Comparative study of intramuscular and intraskeletal osteogenesis by recombinant human bone morphogenetic protein-2. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 87:1999;34-38.
153. King G.N., King N., Hughes F.J. Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo. J. Periodontol. Res. 33:1998;226-236.
154. Yoshida K., Bessho K., Fujimura K., Kusumoto K., Ogawa Y., Tani Y., Iizuka T. Osteoinduction capability of recombinant human bone morphogenetic protein-2 in intramuscular and subcutaneous sites: an experimental study. J. Craniomaxillofac. Surg. 26:1998;112-115.
155. Wurzler K.K., DeWeese T.L., Sebald W., Reddi A.H. Radiation-induced impairment of bone healing can be overcome by recombinant human bone morphogenetic protein-2. J. Craniofac. Surg. 9:1998;131-137.
156. Bostrom M.P., Aspenberg P., Jeppsson C., Salvati E.A. Enhancement of bone formation in the setting of repeated tissue deformation. Clin. Orthop. 350:1998;221-228.
157. Sigurdsson T.J., Fu E., Tatakis D.N., Rohrer M.D., Wikesjo U.M. Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clin. Oral. Implants Res. 8:1997;367-374.
158. Kusumoto K., Bessho K., Fujimura K., Ogawa Y., Iizuka T. Intramuscular osteoinduction and bone marrow formation by the implantation of rhBMP-2 with atelopeptide Type I collagen. Br. J. Oral Maxillofac. Surg. 35:1997;433-437.
159. Kusumoto K., Bessho K., Fujimura K., Konishi Y., Ogawa Y., Iizuka T. Self-regenerating bone implant: ectopic osteoinduction following intramuscular implantation of a combination of rhBMP-2, atelopeptide Type I collagen and porous hydroxyapatite. J. Craniomaxillofac. Surg. 24:1996;360-365.
160. Ono I., Gunji H., Kaneko F., Saito T., Kuboki Y. Efficacy of hydroxyapatite ceramic as a carrier for recombinant human bone morphogenetic protein. J. Craniofac. Surg. 6:1995;238-244.
161. Kusumoto K., Bessho K., Fujimura K., Konishi Y., Ogawa Y., Iizuka T. Comparative study of bone marrow induced by purified BMP and recombinant human BMP-2. Biochem. Biophys. Res. Comm. 215:1995;205-211.
162. Fujimura K., Bessho K., Kusumoto K., Ogawa Y., Iizuka T. Experimental studies on bone inducing activity of composites of atelopeptide type I collagen as a carrier for ectopic osteoinduction by rhBMP-2. Biochem. Biophys. Res. Comm. 208:1995;316-322.
163. Rutherford R.B., Wahle J., Tucker M., Rueger D., Charette M. Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral. Biol. 38:1993;571-576.
164. Gao T.J., Lindholm T.S., Kommonen B., Ragni P., Paronzini A., Lindholm T.C., Jamsa T., Jalovaara P. Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, and Type IV collagen. J. Biomed. Mater. Res. 32:1996;505-512.
165. Friess W., Uludag H., Foskett S., Biron R., Sargeant C. Characterization of absorbable collagen sponges as rhBMP-2 carriers. Int. J. Pharm. 187:1999;91-99.
166. Friess W., Uludag H., Foskett S., Biron R. Bone regeneration with recombinant human bone morphogenetic protein-2 (rhBMP-2) using absorbable collagen sponges (ACS): influence of processing on ACS characteristics and formulation. Pharm. Dev. Technol. 4:1999;387-396.
167. Friess W., Uludag H., Foskett S., Biron R., Sargeant C. Characterization of absorbable collagen sponges as recombinant human bone morphogenetic protein-2 carriers. Int. J. Pharm. 185:1997;51-60.
168. Riedel G.E., Valentin-Opran A. Clinical evaluation of rhBMP-2/ACS in orthopedic trauma: A progress report. Comment in Orthopedics. 22:1999;659-660.
169. Wikesjo E.M., Guglielmoni P., Promsudthi A., Cho K.S., Trombelli L., Selvig K.A., Jin L., Wozney J.M. Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. J. Clin. Periodontol. 26:1999;392-400.
170. Hecht B.P., Fischgrund J.S., Herkowitz H.N., Penman L., Toth J.M., Shirkhoda A. The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model. Spine. 24:1999;629-636.
171. Cochran D.L., Schenk R., Buser D., Wozney J.M., Jones A.A. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. J. Periodontol. 70:1999;139-150.
172. Boyne P.J., Marx R.E., Nevins M., Triplett G., Lazaro E., Lilly L.C., Alder M., Nummikoski P. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int. J. Periodontics Restorative Dent. 17:1997;11-25.
173. Hollinger J.O., Schmitt J.M., Buck D.C., Shannon R., Joh S.P., Zegzula H.D., Wozney J. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J. Biomed. Mater. Res. 43:1998;356-364.
174. Welch R.D., Jones A.L., Bucholz R.W., Reinert C.M., Tjia J.S., Pierce W.A., Wozney J.M., Li X.J. Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model. J. Bone Miner. Res. 13:1998;1483-1490.
175. Kubler N.R., Moser M., Berr K., Faller G., Kirchner T., Sebald W., Reuther J.F. Biological activity of E. coli expressed BMP-4. Mund Kiefer Gesichtschir. Suppl. 1:1998;S149-S152.
176. Howell T.H., Fiorellini J., Jones A., Alder M., Nummikoski P., Lazaro M., Lilly L., Cochran D. A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int. J. Periodontics Restorative Dent. 17:1997;124-139.
177. Fischgrund J.S., James S.B., Chabot M.C., Hankin R., Herkowitz H.N., Wozney J.M., Shirkhoda A. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model. J. Spinal Disord. 10:1997;467-472.
178. Hanisch O., Tatakis D.N., Rohrer M.D., Wohrle P.S., Wozney J.M., Wikesjo U.M. Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. Int. J. Oral Maxillofac. Implants. 12:1997;785-792.
179. Sellers R.S., Peluso D., Morris E.A. The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage. J. Bone Joint Surg. Am. 79:1997;1452-1463.
180. Hanisch O., Tatakis D.N., Boskovic M.M., Rohrer M.D., Wikesjo U.M. Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2. Int. J. Oral Maxillofac. Implants. 12:1997;604-610.
181. Zellin G., Linde A. Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects. J. Biomed. Mater. Res. 35:1997;181-190.
182. Kirker-Head C.A., Nevins M., Palmer R., Nevins M.L., Schelling S.H. A new animal model for maxillary sinus floor augmentation: evaluation parameters. Int. J. Oral Maxillofac. Implants. 12:1997;403-411.
183. Boden S.D., Moskovitz P.A., Morone M.A., Toribitake Y. Video-assisted lateral intertransverse process arthrodesis. Validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and nonhuman primate (rhesus) models. Spine. 21:1996;2689-2697.
184. Boyne P.J. Animal studies of application of rhBMP-2 in maxillofacial reconstruction. Bone. 19:1996;S83-S92.
185. Nevins M., Kirker-Head C., Nevins M., Wozney J.A., Palmer R., Graham D. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int. J. Periodontics Restorative Dent. 16:1996;8-19.
186. Itoh H., Ebara S., Kamimura M., Tateiwa Y., Kinoshita T., Yuzawa Y., Takaoka K. Experimental spinal fusion with use of recombinant human bone morphogenetic protein 2. Spine. 24:1999;1402-1405.
187. Bax B.E., Wozney J.M., Ashhurst D.E. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif. Tissue Int. 65:1999;83-89.
188. King G.N., King N., Cruchley A.T., Wozney J.M., Hughes F.J. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J. Dent. Res. 76:1997;1460-1470.
189. Sheehan J.P., Kallmes D.F., Sheehan J.M., Jane J.A. Jr., Fergus A.H., diPierro C.G., Simmons N.E., Makel D.D., Helm G.A. Molecular methods of enhancing lumbar spine fusion. Neurosurgery. 39:1996;548-554.
190. King G.N., Hughes F.J. Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo. J. Periodontol. 70:1999;1125-1135.
191. Omura S., Mizuki N., Kawabe R., Ota S., Kobayashi S., Fujita K. A carrier for clinical use of recombinant human BMP-2: dehydrothermally cross-linked composite of fibrillar and denatured atelocollagen sponge. Int. J. Oral Maxillofac. Surg. 27:1998;129-134.
192. Kuriloff D.B., Fayad J.N. Tracheal autograft prefabrication using microfibrillar collagen and bone morphogenetic protein. Arch Otolaryngol. Head Neck Surg. 122:1996;1385-1389.
193. Martin G.J. Jr., Boden S.D., Marone M.A., Marone M.A., Moskovitz P.A. Posterolateral intertransverse process spinal arthrodesis with rhBMP-2 in a nonhuman primate: important lessons learned regarding dose, carrier, and safety. J. Spinal Disord. 12:1999;179-186.
194. Giannobile W.V., Ryan S., Shih M.S., Su D.L., Kaplan P.L., Chan T.C. Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects. J. Periodontol. 69:1998;129-137.
195. Ripamonti U., Duneas N., Van Den Heever B., Bosch C., Crooks J. Recombinant transforming growth factor-beta1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. J. Bone Miner. Res. 12:1997;1584-1595.
196. Cochran D.L., Nummikoski P.V., Jones A.A., Makins S.R., Turek T.J., Buser D. Radiographic analysis of regenerated bone around endosseous implants in the canine using recombinant human bone morphogenetic protein-2. Int. J. Oral Maxillofac. Implants. 12:1997;739-748.
197. Grgic M., Jelic M., Basic V., Basic N., Pecina M., Vukicevic S. Regeneration of articular cartilage defects in rabbits by osteogenic protein-1 (bone morphogenetic protein-7). Acta Med. Croatica. 51:1997;23-27.
198. Holliger E.H., Trawick R.H., Boden S.D., Hutton W.C. Morphology of the lumbar intertransverse process fusion mass in the rabbit model: a comparison between two bone graft materials - rhBMP-2 and autograft. J. Spinal Disord. 9:1996;125-128.
199. Fleet J.C., Cashman K., Cox K., Rosen V. The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Endocrinology. 137:1996;4605-4610.
200. Schimandle J.H., Boden S.D., Hutton W.C. Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine. 20:1995;1326-1337.
201. Aono A., Hazama M., Notoya K., Taketomi S., Yamasaki H., Tsukuda R., Sasaki S., Fujisawa Y. Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer. Biochem. Biophys. Res. Common. 210:1995;670-677.
202. Rutherford R.B., Spangberg L., Tucker M., Rueger D., Charette M. The time-course of the induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral. Biol. 39:1994;833-838.
203. Nakashima M. Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins-2 and -4 with collagen matrix. Arch. Oral Biol. 39:1994;1085-1089.
204. Cook S.D., Dalton J.E., Tan E.H., Whitecloud T.S. 3rd, Rueger D.C. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine. 19:1994;1655-1663.
205. Nakashima M. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J. Dent. Res. 73:1994;1515-1522.
206. Miyamoto S., Takaoka K., Okada T., Yoshikawa H., Hashimoto J., Suzuki S., Ono K. Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein. Clin. Orthop. 255:1990;274-285.
207. Miyamoto S., Takaoka K. Bone induction and bone repair by composites of bone morphogenetic protein and biodegradable synthetic polymers. Ann. Chir. Gynaecol. Suppl. 207:1993;69-75.
208. Miyamoto S., Takaoka K., Okada T., Yoshikawa H., Hashimoto J., Suzuki S., Ono K. Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein. Clin. Orthop. 294:1993;333-343.
209. Lovell T.P., Dawson E.G., Nilsson O.S., Urist M.R. Augmentation of spinal fusion with bone morphogenetic protein in dogs. Clin. Orthop. 243:1989;266-274.
210. Kawamura M., Urist M.R. Induction of callus formation by implants of bone morphogenetic protein and associated bone matrix noncollagenous proteins. Clin. Orthop. 236:1988;240-248.
211. Higuchi T., Kinoshita A., Takahashi K., Oda S., Ishikawa I. Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling. J. Periodontol. 70:1999;1026-1031.
212. Saito N., Okada T., Toba S., Miyamoto S., Takaoka K. New synthetic absorbable polymers as BMP carriers: plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers. J. Biomed. Mater. Res. 47:1999;104-110.
213. Toriumi D.M., O'Grady K., Horlbeck D.M., Desai D., Turek T.J., Wozney J. Mandibular reconstruction using bone morphogenetic protein 2: long-term follow-up in a canine model. Laryngoscope. 109:1999;1481-1489.
214. Hollinger J.O., Winn S.R. Tissue engineering of bone in the craniofacial complex. Ann. NY Acad. Sc. 875:1999;379-385.
215. Boyan B.D., Lohmann C.H., Somers A., Niederauer G.G., Wozney J.M., Dean D.D., Carnes D.L. Jr., Schwartz Z. Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivo. J. Biomed. Mater. Res. 46:1999;51-59.
216. Breitbart A.S., Grande D.A., Mason J.M., Barcia M., James T., Grant R.T. Gene-enhanced Tissue Eng: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene. Ann. Plast. Surg. 42:1999;488-495.
217. Isobe M., Yamazaki Y., Mori M., Amagasa T. Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2. J. Oral Maxillofac. Surg. 57:1999;695-698.
218. Wheeler D.L., Chamberland D.L., Schmitt J.M., Buck D.C., Brekke J.H., Hollinger J.O., Joh S.P., Suh K.W. Radiomorphometry and biomechanical assessment of recombinant human bone morphogenetic protein 2 and polymer in rabbit radius ostectomy model. J. Biomed. Mater. Res. 43:1998;365-373.
219. Whang K., Tsai D.C., Nam E.K., Aitken M., Sprague S.M., Patel P.K., Healy K.E. Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J. Biomed. Mater. Res. 42:1998;491-499.
220. Illi O.E., Feldmann C.P. Stimulation of fracture healing by local application of humoral factors integrated in biodegradable implants. Eur. J. Pediatr. Surg. 8:1998;251-255.
221. Puleo D.A., Huh W.W., Duggirala S.S., DeLuca P.P. In vitro cellular responses to bioerodible particles loaded with recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. 41:1998;104-110.
222. Rodgers J.B., Vasconez H.C., Wells M.D., DeLuca P.P., Faugere M.C., Fink B.F., Hamilton D. Two lyophilized polymer matrix recombinant human bone morphogenetic protein-2 carriers in rabbit calvarial defects. J. Craniofac. Surg. 9:1998;147-153.
223. Itoh T., Mochizuki M., Fuda K., Nishimura R., Matsunaga S., Kadosawa T., Sasaki N. Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. J. Vet. Med. Sci. 60:1998;535-538.
224. Itoh T., Mochizuki M., Nishimura R., Matsunaga S., Kadosawa T., Kokubo S., Yokota S., Sasaki N. Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. J. Vet. Med. Sci. 60:1998;451-458.
225. Kirker-Head C.A., Gerhart T.N., Armstrong R., Schelling S.H., Carmel L.A. Healing bone using recombinant human bone morphogenetic protein 2 and copolymer. Clin. Orthop. 349:1998;205-217.
226. Zellin G., Linde A. Treatment of segmental defects in long bones using osteopromotive membranes and recombinant human bone morphogenetic protein-2. An experimental study in rabbits. Sci. J. Plast. Reconstr. Surg. Hand Surg. 31:1997;97-104.
227. Kinoshita A., Oda S., Takahashi K., Yokota S., Ishikawa I. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. J. Periodontol. 68:1997;103-109.
228. Duggirala S.S., Rodgers J.B., DeLuca P.P. The evaluation of lyophilized polymer matrices for administering recombinant human bone morphogenetic protein-2. Pharm. Dev. Technol. 1:1996;165-174.
229. Alpaslan C., Irie K., Takahashi K., Ohashi N., Sakai H., Nakajima T., Ozawa H. Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system. Br. J. Oral Maxillofac. Surg. 34:1996;414-418.
230. Sandhu H.S., Kanim L.E., Kabo J.M., Toth J.M., Zeegen E.N., Liu D., Delamarter R.B., Dawson E.G. Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion. Spine. 21:1996;2115-2122.
231. Sandhu H.S., Kanim L.E., Kabo J.M., Toth J.M., Zeegan E.N., Liu D., Seeger L.L., Dawson E.G. Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model. Spine. 20:1995;2669-2682.
232. Sigurdsson T.J., Lee M.B., Kubota K., Turek T.J., Wozney J.M., Wikesjo U.M. Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J. Periodontol. 66:1995;131-138.
233. Lee S.C., Shea M., Battle M.A., Kozitza K., Ron E., Turek T., Schaub R.G., Hayes W.C. Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix. J. Biomed. Mater. Res. 28:1994;1149-1156.
234. Muschler G.F., Hyodo A., Manning T., Kambic H., Easley K. Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin. Orthop. 308:1994;229-240.
235. Zegzula H.D., Buck D.C., Brekke J., Wozney J.M., Hollinger J.O. Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2). J. Bone Joint Surg. Am. 79:1997;1778-1790.
236. Bostrom M., Lane J.M., Tomin E., Browne M., Berberian W., Turek T., Smith J., Wozney J., Schildhauer T. Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model. Clin. Orthop. 327:1996;272-282.
237. Isobe M., Yamazaki Y., Oida S., Ishihara K., Nakabayashi N., Amagasa T. Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer. J. Biomed. Mater. Res. 32:1996;433-438.
238. Agrawal C.M., Best J., Heckman J.D., Boyan B.D. Protein release kinetics of a biodegradable implant for fracture non-unions. Biomaterials. 16:1995;1255-1260.
239. Renier M.L., Kohn D.H. Development and characterization of a biodegradable polyphosphate. J. Biomed. Mater. Res. 34:1997;95-104.
240. Winet H., Hollinger J.O. Incorporation of polylactide-polyglycolide in a cortical defect: Neoosteogenesis in a bone chamber. J. Biomed. Mater. Res. 27:1993;667-675.
241. Robinson B.P., Hollinger J.O., Szachowicz E.H., Brekke J. Calvarial bone repair with porous D,L-polylactide. Otolaryngol. Head Neck Surg. 112:1995;707-713.
242. Sela J., Applebaum J., Uretzky G. Osteogenesis induced by bone matrix is inhibited by inflammation. Biomater. Med. Devices Artif. Organs. 14:1988;227-237.
243. S.C. Lee, M.A. Shea, K. Battle et al., Healing of large segmental defects in rat femurs is enhanced by rhBMP-2 in a PLGA matrix: A torsional and densitometric assessment. Trans. 40th Ann. Orthop. Res. Soc. (1994) p. 206.
244. Lindholm T.S., Gao T.J. Functional carriers for bone morphogenetic proteins. Ann. Chir. Gynaecol. Suppl. 207:1993;3-12.
245. Kubler N., Urist M.R. Allogeneic bone and cartilage morphogenesis. Rat BMP in vivo and in vitro. J. Craniomaxillofac. Surg. 19:1991;283-288.
246. Kawamura M., Urist M.R. Human fibrin is a physiologic delivery system for bone morphogenetic protein. Clin. Orthop. 235:1988;302-310.
247. Takahashi S., Urist M.R. Differentiation of cartilage on three substrata under the influence of an aggregate of morphogenetic protein and other bone tissue noncollagenous proteins (BMP/iNCP). Clin. Orthop. 207:1986;227-238.
248. Bulpitt P., Aeschlimann D. New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels. J. Biomed. Mater. Res. 47:1999;152-169.
249. Hong L., Tabata Y., Yamamoto M., Miyamoto S., Yamada K., Hashimoto N., Ikada Y. Comparison of bone regeneration in a rabbit skull defect by recombinant human BMP-2 incorporated in biodegradable hydrogel and in solution. J. Biomater. Sci. Polym. Ed. 9:1998;1001-1014.
250. Yamamoto M., Tabata Y., Ikada Y. Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. J. Biomater. Sci. Polym. Ed. 9:1998;439-458.
251. Kubler N.R., Reinhart E., Pistner H., Bill J.S., Reuther J.F. Clinical application of osteoinductive implants in craniofacial surgery. Mund Kiefer Gesichtschir Suppl. 1:1998;S32-S36.
252. Tsuruga E., Takita H., Itoh H., Wakisaka Y., Kuboki Y. Pore size of porous hydroxyapatite as the cell-substratum controls BMP-induced osteogenesis. J. Biochem. 121:1997;317-324.
253. Cole B.J., Bostrom M.P., Pritchard T.L., Sumner D.R., Tomin E., Lane J.M., Weiland A.J. Use of bone morphogenetic protein 2 on ectopic porous coated implants in the rat. Clin. Orthop. 345:1997;219-228.
254. Ono I., Tateshita T., Takita H., Kuboki Y. Promotion of the osteogenetic activity of recombinant human bone morphogenetic protein by basic fibroblast growth factor. J. Craniofac. Surg. 7:1996;418-425.
255. Takahashi T., Tominaga T., Watabe N., Yokobori A.T. Jr., Sasada H., Yoshimoto T. Use of porous hydroxyapatite graft containing recombinant human bone morphogenetic protein-2 for cervical fusion in a caprine model. J. Neurosurg. 90:1999;224-230.
256. Suwa F., Fang Y.R., Toda I., Tang C.S., Yang L.J., Gao Y.H., Ueda Y. SEM study on microvascular changes following implantation of bone morphogenetic protein combined with hydroxyapatite into experimental bone defects. J. Osaka Dent. Univ. 32:1998;27-34.
257. Howard B.K., Brown K.R., Leach J.L., Chang C.H., Rosenthal D.I. Osteoinduction using bone morphogenic protein in irradiated tissue. Arch Otolaryngol. Head Neck Surg. 124:1998;985-988.
258. Koempel J.A., Patt B.S., O'Grady K., Wozney J., Toriumi D.M. The effect of recombinant human bone morphogenetic protein-2 on the integration of porous hydroxyapatite implants with bone. J. Biomed. Mater. Res. 41:1998;59-63.
259. Ono I., Inoue M., Kuboki Y. Promotion of the osteogenetic activity of recombinant human bone morphogenetic protein by prostaglandin E1. Bone. 19:1996;581-588.
260. Cook S.D., Salkeld S.L., Rueger D.C. Evaluation of recombinant human osteogenic protein-1 (rhOP-1) placed with dental implants in fresh extraction sites. J. Oral Implantol. 21:1995;281-289.
261. Ono I., Gunji H., Suda K., Kaneko F., Murata M., Saito T., Kuboki Y. Bone induction of hydroxyapatite combined with bone morphogenetic protein and covered with periosteum. Plast. Reconstr. Surg. 95:1995;1265-1272.
262. Kamegai A., Shimamura N., Naitou K., Nagahara K., Kanematsu N., Mori M. Bone formation under the influence of bone morphogenetic protein/self-setting apatite cement composite as a delivery system. Biomed. Mater. Eng. 4:1994;291-307.
263. Z.B. Qiu, Scanning electronic microscope (SCM) examination of the hydroxylapatite (HA) combined with bone morphogenetic protein (BMP) implanted on the bone surface, Chung Hua Kou Chiang Hsueh Tsa Chih 28 (1993) 79-81, 127-128.
264. Kawamura M., Iwata H., Sato K., Miura T. Chondroosteogenetic response to crude bone matrix proteins bound to hydroxyapatite. Clin. Orthop. 217:1987;281-292.
265. Lee D.D., Tofighi A., Aiolova M., Chakravarthy P., Catalano A., Majahad A., Knaack D. alpha-BSM: a biomimetic bone substitute and drug delivery vehicle. Clin. Orthop. 367:1999;S396-S405.
266. Boden S.D., Martin G.J. Jr., Morone M.A., Ugbo J.L., Moskovitz P.A. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate. Spine. 24:1999;1179-1185.
267. Oda S., Kinoshita A., Higuchi T., Shizuya T., Ishikawa I. Ectopic bone formation by biphasic calcium phosphate (BCP) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2). J. Med. Dent. Sci. 44:1997;53-62.
268. Mao T., Wang C., Zhang S., Wang H., Zhao M., Chen F., Ma Q., Han L. An experimental study on rhBMP-2 composite bone substitute for repairing craniomaxillary bone defects. Chinese J. Dent. Res. 1:1998;21-25.
269. Hollinger J.O., Battistone G.C. Biodegradeable bone repair materials. Clin. Orthop. 207:1986;290-305.
270. Laffargue P., Hildebrand H.F., Rtaimate M., Frayssinet P., Amoureux J.P., Marchandise X. Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects. Bone. 25:1999;S55-S58.
271. Urist M.R., Lietze A., Dawson E. Beta-tricalcium phosphate delivery system for bone morphogenetic protein. Clin. Orthop. 187:1984;277-280.
272. J.O. Hollinger, D. Buck, J. Schmitt, M. Aiolova, D. Knaack, H. Seeherman, J. Li, J. Wozney, D.D. Lee, An injectable endothermically setting Ca PO3 with rhBMP-2 in rabbit defects. Trans. Orthop. Res. Soc. Anaheim, CA (1997), p. 509.
273. Zou L., Zhang D., Wang W. The role of fetus decalcified bone matrix (FDBM) in inducing pure titanium-bone implant integration. Chung-Kuo Hsiu Fu Chung Chien Wai Ko Tsa Chih/Chinese Journal of Reparative and Reconstructive Surgery. 12:1998;184-188.
274. Shah A.K., Lazatin J., Sinha R.K., Lennox T., Hickok N.J., Tuan R.S. Mechanism of BMP-2 stimulated adhesion of osteoblastic cells to titanium alloy. Biol. Cell. 91:1999;131-142.
275. Boden S.D., Martin G.J. Jr., Horton W.C., Truss T.L., Sandhu H.S. Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage. J. Spinal. Disord. 11:1998;95-101.
276. Ong J.L., Cardenas H.L., Cavin R., Carnes D.L. Jr. Osteoblast responses to BMP-2-treated titanium in vitro. Int. J. Oral. Maxillofac. Implants. 12:1997;649-654.
277. Ong J.L., Carnes D.L., Cardenas H.L., Cavin R. Surface roughness of titanium on bone morphogenetic protein-2 treated osteoblast cells in vitro. Implant Dent. 6:1997;19-24.
278. Kim K.J., Itoh T., Kotake S. Effects of recombinant human bone morphogenetic protein-2 on human bone marrow cells cultured with various biomaterials. J. Biomed. Mater. Res. 35:1997;279-285.
279. Kawai T., Mieki A., Ohno Y., Umemura M., Kataoka H., Kurita S., Koie M., Jinde T., Hasegawa J., Urist M.R. Osteoinductive activity of composites of bone morphogenetic protein and pure titanium. Clin. Orthop. 290:1993;296-305.
280. A.K. Shah, N.J. Hickok, R.S. Tuan, Involvement of P125-FAK in BMP-2 and TGF-?1 effects on primary human osteoblast interaction with titanium alloy T16A 14V. Trans. Orthop. Res. Soc. Anaheim, CA (1999), p. 881.
281. Covey D.C., Albright J.A. Clinical induction of bone repair with demineralized bone matrix or a bone morphogenetic protein. Orthop. Rev. 18:1989;857-863.
282. Schwarz N., Redl H., Li Z., Schlag G., Dinges H.P., Eschberger J. Early osteoinduction in rats is not altered by fibrin sealent. Clin. Orthop. 293:1993;353-359.
283. Takaoka K., Yoshikawa H., Hashimoto J., Miyamoto S., Masuhara K., Nakahara H., Matsui M., Ono K. Purification and characterization of a bone-inducing protein from a murine osteosarcoma (Dunn type). Clin. Orthop. 292:1993;329-336.
284. Margolin M.D., Cogan A.G., Taylor M., Buck D., McAllister T.N., Toth C., McAllister B.S. Maxillary sinus augmentation in the non-human primate: a comparative radiographic and histologic study between recombinant human osteogenic protein-1 and natural bone mineral. J. Periodontol. 69:1998;911-919.
285. McAllister B.S., Margolin M.D., Cogan A.G., Taylor M., Wollins J. Residual lateral wall defects following sinus grafting with recombinant human osteogenic protein-1 or Bio-Oss in the chimpanzee. Int. J. Periodontics Restorative Dent. 18:1998;227-239.
286. Terheyden H., Jepsen S., Vogeler S., Tucker M., Rueger D.C. Recombinant human osteogenic protein 1 in the rat mandibular augmentation model: differences in morphology of the newly formed bone are dependent on the type of carrier. Mund Kiefer Gesichtschir. 1:1997;272-275.
287. Yamazaki Y., Oida S., Akimoto Y., Shioda S. Response of the mouse femoral muscle to an implant of a composite of bone morphogenetic protein and plaster of Paris. Clin. Orthop. 234:1988;240-249.
288. Scaduto A.A., Lieberman J.R. Gene therapeutics for osteoinduction. Clin. Orthop. 30:1999;625-633.
289. Ludwig S.C., Boden S.D. Osteoinductive bone graft substitutes for spinal fusion: a basic science summary. Clin. Orthop. 30:1999;635-645.
290. Alden T.D., Pittman D.D., Hankins G.R., Beres E.J., Engh J.A., Das S., Hudson S.B., Kerns K.M., Kallmes D.F., Helm G.A. In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector. Human Gene Ther. 10:1999;2245-2253.
291. Okubo Y., Bessho K., Fujimura K., Iizuka T., Miyatake S. Expression of bone morphogenetic protein-2 via adenoviral vector in C2C12 myoblasts induces differentiation into the osteoblast lineage. Biochem. Biophys. Res. Common. 262:1999;739-743.
292. Sittinger M., Perka C., Schultz O., Haupl T., Burmester G.R. Joint cartilage regeneration by tissue engineering. Z. Rheumatol. 58:1999;130-135.
293. Musgrave D.S., Bosch P., Ghivizzani S., Robbins P.D., Evans C.H., Huard J. Adenovirus-mediated direct gene therapeutics with bone morphogenetic protein-2 produces bone. Bone. 24:1999;541-547.
294. Lieberman J.R., Daluiski A., Stevenson S., Wu L., McAllister P., Lee Y.P., Kabo J.M., Finerman G.A., Berk A.J., Witte O.N. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J. Bone Joint Surg. Am. 81:1999;905-917.
295. Mason J.M., Grande D.A., Barcia M., Grant R., Pergolizzi R.G., Breitbart A.S. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapeutics for osteochondral repair. Gene Ther. 5:1998;1098-1104.
296. Lou J., Xu F., Merkel K., Manske P. Gene therapeutiucs: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo. J. Orthop. Res. 17:1999;43-50.
297. Niyibizi C., Baltzer A., Lattermann C., Oyama M., Whalen J.D., Robbins P.D., Evans C.H. Potential role for gene therapy in the enhancement of fracture healing. Clin. Orthop. 355:1998;S148-S153.
298. Slavkin H.C. Cell biology, disease susceptibility and innovative therapeutics. J. Am. Dent. Assoc. 129:1998;1462-1466.
299. Lieberman J.R., Le L.Q., Wu L., Finerman G.A., Berk A., Witte O.N., Stevenson S. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J. Orthop. Res. 16:1998;330-339.
300. Fang J., Zhu Y.Y., Smiley E., Bonadio J., Rouleau J.P., Goldstein S.A., McCauley L.K., Davidson B.L., Roessler B.J. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc. Nat. Acad. Sci. USA. 93:1996;5753-5758.
301. J. Lieberman, S. Stevenson, L.Q. Le, Adenoviral gene transfer of recombinant BMP-2 into human and rodent bone marrow cells induces bone formation in vivo, Trans. Orthop. Res. Soc. San Francisco, CA (1997), p. 427.
302. J. Lou, Ludwig, J.F. Zhang, P.R. Manske, BMP 12 gene transferred mesenchymal progenitor cells could form tendon like tissue in vivo, Trans. Orthop. Res. Soc. Anaheim, CA (1999), p. 63.
303. A.W. Baltzer, Bone healing induced by adenoviral based gene therapy with BMP-2 and TGF-β, Trans. Orthop. Res. Soc. Anaheim, CA, p. 308.
304. Einhorn T.A. Clinical applications of recombinant gene technology: bone and cartilage repair. Cells Materials. 2:1992;1-11.
305. Sandhu H.S., Grewal H.S., Parvataneni H. Bone grafting for spinal fusion. Clin. Orthop. 30:1999;685-698.
306. Martin G.J., Boden S.D., Titus L. Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion. Spine. 24:1999;2188-2193.
307. Sandhu H.S., Kanim L.E., Toth J.M., Kabo J.M., Liu D., Delamarter R.B., Dawson E.G. Experimental spinal fusion with recombinant human bone morphogenetic protein-2 without decortication of osseous elements. Spine. 22:1997;1171-1180.
308. Helm G.A., Sheehan J.M., Sheehan J.P., Jane J.A., diPierro C.G., Simmons N.E., Gillies G.T., Kallmes D.F., Sweeney T.M. Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion. J. Neurosurg. 86:1997;93-100.
309. Cunningham B.W., Kanayama M., Parker L.M., Weis J.C., Sefter J.C., Fedder I.L., McAfee P.C. Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine. A comparative endoscopic study using the Bagby and Kuslich interbody fusion device. Spine. 24:1999;509-518.
310. Zdeblick T.A., Ghanayem A.J., Rapoff A.J., Swain C., Bassett T., Cooke M.E., Markel M. Cervical interbody fusion cages. An animal model with and without bone morphogenetic protein. Spine. 23:1998;758-765.
311. S.D. Boden, T.A. Zdeblick, H.S. Sandhu, The use of rhBMP-2 in interbody fusion cages: definitive evidence of osteoinduction in humans. Annual Meeting of the American Academy of Orthopedic Surgeons. Anaheim, CA, 1999.
312. Lane J.M., Yasko A.W., Tomin E., Cole B.J., Waller S., Browne M., Turek T., Gross J. Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair. Clin. Orthop. 361:1999;216-227.
313. Zellin G. Growth factors and bone regeneration. Implications of barrier membranes. Swed. Dent. J. 129:1998;7-65.
314. Teixeira J.O., Urist M.R. Bone morphogenetic protein induced repair of compartmentalized segmental diaphyseal defects. Arch Orthop. Trauma Surg. 117:1998;27-34.
315. Cook S.D., Salkeld S.L., Brinker M.R., Wolfe M.W., Rueger D.C. Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects. J. Orthop. Trauma. 12:1998;407-412.
316. Bostrom M.P., Saleh K.J., Einhorn T.A. Osteoinductive growth factors in preclinical fracture and long bone defects models. Clin. Orthop. 30:1999;647-658.
317. T. Turek, M.P. Bostrom, N.P. Camacho, The acceleration of fracture healing in a rabbit ulnar osteotomy model with bone morphogenetic, protein 2, Trans Orthop Res Soc, San Francisco, CA (1997), p. 526.
318. Bostrom M.P., Camacho N.P. Potential role of bone morphogenetic proteins in fracture healing. Clin. Orthop. Suppl. 355:1998;S274-S282.
319. Krebsbach P.H., Mankani M.H., Satomura K., Kuznetsov S.A., Robey P.G. Repair of craniotomy defects using bone marrow stromal cells. Transplantation. 66:1998;1272-1278.
320. Ono I., Tateshita T., Kuboki Y. Prostaglandin E1 and recombinant bone morphogenetic protein effect on strength of hydroxyapatite implants. J. Biomed. Mater. Res. 45:1999;337-344.
321. Boyne P.J., Nath R., Nakamura A. Human recombinant BMP-2 in osseous reconstruction of simulated cleft palate defects. Br. J. Oral Maxillofac. Surg. 36:1998;84-90.
322. Gordh M., Alberius P., Johnell O., Lindberg L., Linde A. Osteopromotive membranes enhance onlay integration and maintenance in the adult rat skull. Int. J. Oral Maxillofac. Surg. 27:1998;67-73.
323. Khouri R.K., Brown D.M., Koudsi B., Deune E.G., Gilula L.A., Cooley B.C., Reddi A.H. Repair of calvarial defects with flap tissue: role of bone morphogenetic proteins and competent responding tissues. Plast. Reconstr. Surg. 98:1996;103-109.
324. Linde A., Hedner E. Recombinant bone morphogenetic protein-2 enhances bone healing, guided by osteopromotive e-PTFE membranes: an experimental study in rats. Calcif. Tissue Int. 56:1995;549-553.
325. Nevins M., Jovanovic S.A. Localized bone reconstruction as an adjunct to dental implant placement. Curr. Opin. Periodontol. 4:1997;109-118.
326. Ripamonti U., Reddi A.H. Tissue Eng, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins. Crit. Rev. Oral. Biol. Med. 8:1997;154-163.
327. Cochran D.L., Wozney J.M. Biological mediators for periodontal regeneration. Periodontol 2000. 19:1999;40-58.
328. Lee M.B. Bone morphogenetic proteins: background and implications for oral reconstruction: A review. J. Clin. Periodontol. 24:1997;355-365.
329. King G.N., King N., Hughes F.J. The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects. J. Periodontol. 69:1998;561-570.
330. Maguire H., Torabinejad M., McKendry D., McMillan P., Simon J.H. Effects of resorbable membrane placement and human osteogenic protein-1 on hard tissue healing after periradicular surgery in cats. J. Endod. 24:1998;720-725.
331. Ripamonti U., Heliotis M., Rueger D.C., Sampath T.K. Induction of cementogenesis by recombinant human osteogenic protein-1 (hop-1/bmp-7) in the baboon (Papio ursinus). Arch Oral. Biol. 41:1996;121-126.
332. Lianjia Y., Yuhao G., White F.H. Bovine bone morphogenetic protein-induced dentinogenesis. Clin. Orthop. 295:1993;305-312.
333. Wozney J.M. Bone morphogenetic proteins. Prog. Growth Fac. Res. 1:1989;267-280.
334. Yasko A.W., Lane J.M., Fellinger E.J., et al. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). J. Bone Joint Surg. Am. 74A:1992;659-671.
335. T.K. Sampath, E. Ozkaynak, W. Jones, H. Sasak, R. Tucker, M. Tucker, W. Kusmik, J. Lightholder, R. Pang, C. Corbett, H. Oppermann, D.C. Rueger, Recombinant human osteogenic protein (hOP-1) induces new bone formation with a specific activity comparable to that of natural bone OP, Trans. 38th Ann. Orthop. Res. Soc. (1992) 72.
336. Luyten F.P., Cunningham N.S., Vucicevic S. Advances in osteogenin and related bone morphogenetic proteins in bone induction and repair. Acta Orthop. Belg. 58:(Supp 1):1992;263-267.
337. Richardson D.W., Nunamaker D.M. Evaluation of plate luting, using an in vivo ovine osteotomy model. Am. J. Vet. Res. 52:1991;1468-1473.
338. Wolfman N.M., Hattersley G., Cox K., Celeste A.J., Nelson R., Yamaji N., Dube J.L., DiBlasio-Smith E., Nove J., Song J.J., Wozney J.M., Rosen V. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J. Clin. Invest. 100:1997;321-330.
339. Miyamoto S., Takaoka K., Yonenobu K., Ono K. Ossification of the ligamentum flavum induced by bone morphogenetic protein. An experimental study in mice. J. Bone Joint Surg. 74:(B):1992;279-283.
340. Itoh O. An experimental study on effect of bone morphogenetic protein and fibrin sealant in tendon implantation into bone. J. Jpn. Orthop. Assoc. 65:1991;580-590.
341. Mattioli-Belmonte M., Gigante A., Muzzarelli R.A., Politano R., De Benedittis A., Specchia N., Buffa A., Biagini G., Greco F. N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage. Med. Biol. Eng. Comput. 37:1999;130-134.
342. Klein-Nulend J., Louwerse R.T., Heyligers I.C., Wuisman P.I., Semeins C.M., Goei S.W., Burger E.H. Osteogenic protein (OP-1, BMP-7) stimulates cartilage differentiation of human and goat perichondrium tissue in vitro. J. Biomed. Mater. Res. 40:1998;614-620.
343. Bhargava M.M., Attia E.T., Murrell G.A., Dolan M.M., Warren R.F., Hannafin J.A. The effect of cytokines on the proliferation and migration of bovine meniscal cells. Am. J. Sports Med. 27:1999;636-643.
344. Ekelund A., Brosjo O., Nilsson M. Experimental induction of heterotopic bone. Clin. Orthop. 263:1991;102-112.
345. Haynesworth S.E., Goshima J., Goldberg V.M., Caplan A.L. Characterization of cells with osteogenic potential from human marrow. Skeletal Res. Ctr. Bone. 13:1992;81-88.
346. M. Liebergall, R.G. Young, J.H. Reese, N. Ozawa, A.L. Caplan, The effect of cellular manipulation and TGF-β in composite graft mode, Trans. 39th Ann. Meet. Orthop. Res. Soc. (1993) 481.
347. Si X., Jin Y., Yang L. Induction of new bone by ceramic bovine bone with recombinant human bone morphogenetic protein 2 and transforming growth factor beta. Int. J. Oral Maxillofac. Surg. 27:1998;310-314.
348. Bab I.A., Einhorn T.A. Regulatory role of osteogenic growth polypeptides in bone formation and hemopoiesis. Cri. Rev. Euk. Gene Ex. 3:1993;31-46.
349. Lefer A.M., Tsao P.S., Ma X.L., Sampath T.K. Anti-ischemic and endothelial protective actions of recombinant human osteogenic protein (hOP-1). J. Mol. Cell Cardiol. 24:1992;585-593.
350. Perides G., Jensen F.E., Edgecomb P., Rueger D.C., Charness M.E. Neuroprotective effect of human osteogenic protein-1 in a rat model of cerebral hypoxia/ischemia. Neurosci. Lett. 187:1995;21-24.
351. Godin R.E., Robertson E.J., Dudley A.T. Role of BMP family members during kidney development. Int. J. Dev. Biol. 43:1999;405-411.
352. Godin R.E., Takaesu N.T., Robertson E.J., Dudley A.T. Regulation of BMP7 expression during kidney development. Development. 125:1998;3473-3482.
353. Kingsley D.M., Bland A.E., Grubber J.M., Marker P.C., Russell L.B., Copeland N.G., Jenkins N.A. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell. 71:1992;399-410.
354. Tabas J.A., Zasloff M., Wasmuth J.J., Emanuel B.S., Altherr M.R., McPherson J.D., Wozney J.M., Kaplan F.S. Bone morphogenetic protein: Chromosomal localization of human genes for BMP1, BMP2A, and BMP3. Genomics. 9:1991;283-289.
355. Kaplan F.S., Shore E.M. Encrypted morphogens of skeletogenesis: biological errors and pharmacologic potentials. Biochem. Pharmacol. 55:1998;373-382.