Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells

Acta Biomaterialia

Volumn 4, Issue 3, 2008, Pages 477-489

  Shen, Yi Hao ^a   Shoichet, Molly S ^a,b,c   Radisic, Milica ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Collagen scaffold; Covalent immobilization; Endothelial cell; Tissue engineering; VEGF

Indexed keywords

CELL ENGINEERING; CELL IMMOBILIZATION; COLLAGEN; HISTOLOGY; SCAFFOLDS (BIOLOGY); TISSUE;

COLLAGEN SCAFFOLDS; COVALENT IMMOBILIZATION; ENDOTHELIAL-CELLS; ENGINEERED TISSUES; FUNCTIONAL TISSUE; IN-VITRO; TISSUES ENGINEERINGS; TRANSPORT CAPACITY; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULARIZATION;

ENDOTHELIAL CELLS;

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; COLLAGEN; LACTIC ACID; MOLECULAR SCAFFOLD; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL DENSITY; CELL PROLIFERATION; CELL TRANSPORT; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE UTILIZATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN IMMOBILIZATION; PROTEIN TRANSPORT; TISSUE BLOOD FLOW; TISSUE ENGINEERING; VASCULARIZATION;

EID: 41549140437     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2007.12.011     Document Type: Article

References (44)

1. Caspi O., Lesman A., Basevitch Y., Gepstein A., Arbel G., Habib I.H., et al. Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ Res 100 (2007) 263-272
2. Morritt A.N., Bortolotto S.K., Dilley R.J., Han X., Kompa A.R., McCombe D., et al. Cardiac tissue engineering in an in vivo vascularized chamber. Circulation 115 (2007) 353-360
3. Radisic M., Euloth M., Yang L., Langer R., Freed L.E., and Vunjak-Novakovic G. High-density seeding of myocyte cells for cardiac tissue engineering. Biotechnol Bioeng 82 (2003) 403-414
4. Radisic M., Yang L., Boublik J., Cohen R.J., Langer R., Freed L.E., et al. Medium perfusion enables engineering of compact and contractile cardiac tissue. Am J Physiol Heart Circ Physiol 286 (2004) H507-H516
5. Radisic M., Malda J., Epping E., Geng W., Langer R., and Vunjak-Novakovic G. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnol Bioeng 93 (2006) 332-343
6. Freed L.E., Guilak F., Guo X.E., Gray M.L., Tranquillo R., Holmes J.W., et al. Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Eng 12 (2006) 3285-3305
7. Laschke M.W., Harder Y., Amon M., Martin I., Farhadi J., Ring A., et al. Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes. Tissue Eng 12 (2006) 2093-2104
8. Boontheekul T., and Mooney D.J. Protein-based signaling systems in tissue engineering. Curr Opin Biotechnol 14 (2003) 559-565
9. Ahrendt G., Chickering D.E., and Ranieri J.P. Angiogenic growth factors: a review for tissue engineering. Tissue Eng 4 (1998)
10. Neufeld G., Cohen T., Gengrinovitch S., and Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 13 (1999) 9-22
11. Dougher M., and Terman B.I. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 18 (1999) 1619-1627
12. Olsson A.K., Dimberg A., Kreuger J., and Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 7 (2006) 359-371
13. Richardson T.P., Peters M.C., Ennett A.B., and Mooney D.J. Polymeric system for dual growth factor delivery. Nat Biotechnol 19 (2001) 1029-1034
14. Smith M.K., Peters M.C., Richardson T.P., Garbern J.C., and Mooney D.J. Locally enhanced angiogenesis promotes transplanted cell survival. Tissue Eng 10 (2004) 63-71
15. Murphy W.L., Peters M.C., Kohn D.H., and Mooney D.J. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials 21 (2000) 2521-2527
16. Perets A., Baruch Y., Weisbuch F., Shoshany G., Neufeld G., and Cohen S. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A 65 (2003) 489-497
17. Ferreira L.S., Gerecht S., Fuller J., Shieh H.F., Vunjak-Novakovic G., and Langer R. Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials 28 (2007) 2706-2717
18. Yeo Y., Geng W., Ito T., Kohane D.S., Burdick J.A., and Radisic M. Photocrosslinkable hydrogel for myocyte cell culture and injection. J Biomed Mater Res B Appl Biomater 81B (2006) 312-322
19. Sigrist S., Mechine-Neuville A., Mandes K., Calenda V., Braun S., Legeay G., et al. Influence of VEGF on the viability of encapsulated pancreatic rat islets after transplantation in diabetic mice. Cell Transplant 12 (2003) 627-635
20. Ito Y., Liu S.Q., and Imanishi Y. Enhancement of cell growth on growth factor-immobilized polymer film. Biomaterials 12 (1991) 449-453
21. Ito Y., Zheng J., Imanishi Y., Yonezawa K., and Kasuga M. Protein-free cell culture on an artificial substrate with covalently immobilized insulin. Proc Natl Acad Sci USA 93 (1996) 3598-3601
22. Taguchi T., Kishida A., Akashi M., and Maruyama I. Immobilization of human vascular endothelial growth factor (VEGF165) onto biomaterials: an evaluation of the biological activity of immobilized VEGF165. J Bioact Comp Polym 15 (2000) 309-320
23. Ito Y., Hasuda H., Terai H., and Kitajima T. Culture of human umbilical vein endothelial cells on immobilized vascular endothelial growth factor. J Biomed Mater Res A 74 (2005) 659-665
24. Backer M.V., Patel V., Jehning B.T., Claffey K.P., and Backer J.M. Surface immobilization of active vascular endothelial growth factor via a cysteine-containing tag. Biomaterials 27 (2006) 5452-5458
25. Zisch A.H., Schenk U., Schense J.C., Sakiyama-Elbert S.E., and Hubbell J.A. Covalently conjugated VEGF-fibrin matrices for endothelialization. J Control Release 72 (2001) 101-113
26. Kennedy M., and Keller G.M. Hematopoietic commitment of ES cells in culture. Methods Enzymol 365 (2003) 39-59
27. Karageorgiou V., Meinel L., Hofmann S., Malhotra A., Volloch V., and Kaplan D. Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells. J Biomed Mater Res A 71 (2004) 528-537
28. Pieper J.S., Hafmans T., van Wachem P.B., van Luyn M.J., Brouwer L.A., Veerkamp J.H., and van Kuppevelt T.H. Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue generation in rats. J Biomed Mater Res 62 (2002) 185-194
29. Vasita R., and Katti D.S. Growth factor-delivery systems for tissue engineering: a materials perspective. Expert Rev Med Dev 3 (2006) 29-47
30. Kapur T.A., and Shoichet M.S. Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J Biomed Mater Res A 68 (2004) 235-243
31. Moore K., MacSween M., and Shoichet M. Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds. Tissue Eng 12 (2006) 267-278
32. Li W., and Keller G. VEGF nuclear accumulation correlates with phenotypical changes in endothelial cells. J Cell Sci 113 (2000) 1525-1534
33. Nor J.E., Christensen J., Mooney D.J., and Polverini P.J. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 154 (1999) 375-384
34. Gerber H.P., McMurtrey A., Kowalski J., Yan M., Keyt B.A., Dixit V., et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 273 (1998) 30336-30343
35. Hutchings H., Ortega N., and Plouet J. Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation. FASEB J 17 (2003) 1520-1522
36. Enever P.A., Shreiber D.I., and Tranquillo R.T. A novel implantable collagen gel assay for fibroblast traction and proliferation during wound healing. J Surg Res 105 (2002) 160
37. Cross M.J., Dixelius J., Matsumoto T., and Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem Sci 28 (2003) 488
38. Muller Y.A., Li B., Christinger H.W., Wells J.A., Cunningham B.C., and de Vos A.M. Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc Natl Acad Sci USA 94 (1997) 7192
39. Walsh T.P., and Grant G.H. Computer modelling of the receptor-binding domains of VEGF and PIGF. Protein Eng 10 (1997) 389
40. Krilleke D., DeErkenez A., Schubert W., Giri I., Robinson G.S., Ng Y.S., et al. Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. J Biol Chem 282 (2007) 28045
41. Koch S., Yao C., Grieb G., Prevel P., Noah E.M., and Steffens G.C. Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF. J Mater Sci Mater Med 17 (2006) 735-741
42. Narmoneva D.A., Vukmirovic R., Davis M.E., Kamm R.D., and Lee R.T. Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation 110 (2004) 962-968
43. Kaihara S., Borenstein J., Koka R., Lalan S., Ochoa E.R., Ravens M., et al. Silicon micromachining to tissue engineer branched vascular channels for liver fabrication. Tissue Eng 6 (2000) 105-117
44. Helm C.L., Zisch A., and Swartz M.A. Engineered blood and lymphatic capillaries in 3D VEGF-fibrin-collagen matrices with interstitial flow. Biotechnol Bioeng 96 (2007) 167-176