Precise location of proton of beta-secretase for catalytic aspartates (Asp 32 and Asp 228) in Alzheimer's patients

Neural Regeneration Research

Volumn 5, Issue 8, 2010, Pages 572-578

  Liu, Shu ^a   Wang, Huaqiao ^a   Zhou, Lihua ^a   Yao, Zhibin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Digital medicine; Enzymatic hydrolysis; Neural regeneration; Neurodegenerative diseases; QM MM; Quantum chemistry calculation; secretase

Indexed keywords

ASPARTIC ACID; BETA SECRETASE; ENZYME; OXYGEN; PEPTIDE; PROTON; WATER;

ALZHEIMER DISEASE; ARTICLE; CALCULATION; CELL PROTECTION; COMPUTER; COMPUTER PROGRAM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DRUG DESIGN; ENERGY; ENTHALPY; HYDROLYSIS; MOLECULAR MECHANICS; NERVE CELL; NERVE REGENERATION; PROTON TRANSPORT; QUANTUM CHEMISTRY; QUANTUM MECHANICS; SIMULATION;

EID: 78650198012     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2010.08.002     Document Type: Article

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