Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 63, Issue 12, 2007, Pages 1080-1083

  Tuan, Han Fang ^a   Erskine, Peter ^b   Langan, Paul ^c,d   Cooper, Jon ^b   Coates, Leighton ^a,d  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF TOLEDO   (United States)

Author keywords

Endothiapepsin; Gem diol inhibitors; Neutron diffraction

Indexed keywords

ASPARTIC PROTEINASE; ENDOTHIAPEPSIN; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; MORPHOLINE DERIVATIVE; PD 135,040; PD-135,040; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; GENETICS; METABOLISM; NEUTRON DIFFRACTION; PROTEIN BINDING; X RAY DIFFRACTION;

ASPARTIC ENDOPEPTIDASES; BINDING SITES; CRYSTALLIZATION; ENZYME INHIBITORS; IMIDAZOLES; MOLECULAR STRUCTURE; MORPHOLINES; NEUTRON DIFFRACTION; PROTEIN BINDING; X-RAY DIFFRACTION;

EID: 36849081999     PISSN: 17443091     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309107061283     Document Type: Article

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